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Protein Overview: SIP2

General Information:
Name(s) found: SIP2 / YGL208W [SGD]
Description(s) found:
Found 27 descriptions.
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  • One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 415 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    AMP-activated protein kinase complex [IDALink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    Biological Process: signal transduction [IGILink to PubMed article]
    regulation of protein complex assembly [IGILink to PubMed article]
    invasive growth in response to glucose limitation [IGILink to PubMed article]
    protein amino acid phosphorylation [IGILink to PubMed article]
    replicative cell aging [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    cellular response to glucose starvation [IMPLink to PubMed article]
    Molecular Function: AMP-activated protein kinase activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTTTSHPAQ KKQTTKKCRA PIMSDVREKP SNAQGCEPQE MDAVSKKVTE LSLNKCSDSQ  60
   61 DAGQPSREGS ITKKKSTLLL RDEDEPTMPK LSVMETAVDT DSGSSSTSDD EEGDIIAQTT 120
  121 EPKQDASPDD DRSGHSSPRE EGQQQIRAKE ASGGPSEIKS SLMVPVEIRW QQGGSKVYVT 180
  181 GSFTKWRKMI GLIPDSDNNG SFHVKLRLLP GTHRFRFIVD NELRVSDFLP TATDQMGNFV 240
  241 NYIEVRQPEK NPTNEKIRSK EADSMRPPTS DRSSIALQIG KDPDDFGDGY TRFHEDLSPR 300
  301 PPLEYTTDIP AVFTDPSVME RYYYTLDRQQ SNTDTSWLTP PQLPPQLENV ILNKYYATQD 360
  361 QFNENNSGAL PIPNHVVLNH LVTSSIKHNT LCVASIVRYK QKYVTQILYT PIESS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GAL83 SIP2 SNF1 SNF4
    View Details (MIPS) Mewes HW, et al. (2004) GAL83 SIP1 SIP2 SIP4 SNF1 SNF4
    View Details Krogan NJ, et al. (2006) GAL83 RAD30 SAK1 SIP1 SIP2 SNF1 SNF4
    View Details Gavin AC, et al. (2002) BMH1 CKA1 CKB1 GAL83 REG1 SAK1 SIP1 SIP2 SNF1 SNF4
    View Details Ho Y, et al. (2002) ARC35 GAL83 IDH2 SEC53 SEC7 SIP2 SNF1 SNF4 TCP1 YMR086W
    View Details Qiu et al. (2008) GAL83 SIP1 SIP2 SIP4 SNF1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen FUN19 SIP2 2 Unpublished Fields Lab Data
    View Screen MPC54 SIP2 2 Unpublished Fields Lab Data
    View Screen IMD1 SIP2 2 Unpublished Fields Lab Data
    View Screen YCK1 SIP2 2 Unpublished Fields Lab Data
    View Screen KAP104 SIP2 2 Unpublished Fields Lab Data
    View Screen PRP40 SIP2 2 Unpublished Fields Lab Data
    View Screen SNF1 SIP2 2 Uetz P, et al. (2000)
    View Screen YPI1 SIP2 2 Hazbun TR, et al. (2003)
    View Screen SNF4 SIP2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] deduced N/A No confident structure predictions are available.
    2 View Details [98..415] MSA 11.051951 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • AMP-activated protein kinase activity
    		•  4.78975226545815 bayes_pls_golite062009
  • binding
    		•  2.65544526722793 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.18099602369564 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.66390525860632 bayes_pls_golite062009
  • kinase activity
    		•  1.64560031716993 bayes_pls_golite062009
  • cation channel activity
    		•  1.61654093209843 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  1.56948414427108 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.56948414427108 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.53194692728729 bayes_pls_golite062009
  • protein binding
    		•  1.50286160643298 bayes_pls_golite062009
  • gated channel activity
    		•  1.48812502999143 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.46948685366075 bayes_pls_golite062009
  • protein kinase activity
    		•  1.44964326848891 bayes_pls_golite062009
  • transferase activity
    		•  1.26709925711174 bayes_pls_golite062009
  • signal transducer activity
    		•  1.12993648323166 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.12993648323166 bayes_pls_golite062009
  • ion channel activity
    		•  1.10689326077049 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.726369450752205 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.60798225319459 bayes_pls_golite062009
  • actin binding
    		•  0.54002000529721 bayes_pls_golite062009
  • enzyme binding
    		•  0.37496592438035 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  0.252254893587557 bayes_pls_golite062009
  • potassium channel activity
    		•  0.0778382534131277 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle