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Protein Overview: GAL83

General Information:
Name(s) found: GAL83 / YER027C [SGD]
Description(s) found:
Found 29 descriptions.
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  • One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 417 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    nuclear envelope lumen [IDALink to PubMed article]
    AMP-activated protein kinase complex [IDALink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    Biological Process: signal transduction [IGILink to PubMed article]
    regulation of protein complex assembly [IGILink to PubMed article]
    cell adhesion [IMPLink to PubMed article]
    invasive growth in response to glucose limitation [IMPLink to PubMed article]
    protein amino acid phosphorylation [IGILink to PubMed article]
    Molecular Function: AMP-activated protein kinase activity [IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGDNPENKD ASMLDVSDAA SNTTINGKHS ADSTNEASLA YTFSQMNVDN PNELEPQHPL  60
   61 RHKSSLIFND DDDDEIPPYS NHAENGSGET FDSDDDIDAS SSSSIDSNEG DIHDADMTGN 120
  121 TLQKMDYQPS QQPDSLQNQG FQQQQEQQQG TVEGKKGRAM MFPVDITWQQ GGNKVYVTGS 180
  181 FTGWRKMIGL VPVPGQPGLM HVKLQLPPGT HRFRFIVDNE LRFSDYLPTA TDQMGNFVNY 240
  241 MEVSAPPDWG NEPQQHLAEK KANHVDDSKL SKRPMSARSR IALEIEKEPD DMGDGYTRFH 300
  301 DETPAKPNLE YTQDIPAVFT DPNVMEQYYL TLDQQQNNHQ NMAWLTPPQL PPHLENVILN 360
  361 SYSNAQTDNT SGALPIPNHV ILNHLATSSI KHNTLCVASI VRYKQKYVTQ ILYTPLQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GAL83 REG1 SAK1 SIP1 SIP2 SNF1 SNF4
    View Details (MIPS) Mewes HW, et al. (2004) GAL83 SIP1 SIP2 SIP4 SNF1 SNF4
    View Details Krogan NJ, et al. (2006) GAL83 RAD30 SAK1 SIP1 SIP2 SNF1 SNF4
    View Details Gavin AC, et al. (2006) GAL83 REG1 SIP1 SNF1 SNF4
    View Details Gavin AC, et al. (2002) BMH1 CKA1 CKB1 GAL83 REG1 SAK1 SIP1 SIP2 SNF1 SNF4
    View Details Ho Y, et al. (2002) ARC35 ARF1 CAF20 CDC33 GAL83 GIS4 IDH2 NAP1 PRB1 SEC53 SIP2 SNF1 SNF4 TCP1 UBI4
    View Details Qiu et al. (2008) GAL83 SIP1 SIP2 SIP4 SNF1 SNF4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GAL83 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..130] deduced N/A No confident structure predictions are available.
    2 View Details [131..225] PSI-BLAST 27.69897 Glycosyltrehalose trehalohydrolase, N-terminal domain N; Glycosyltrehalose trehalohydrolase; Glycosyltrehalose trehalohydrolase, central domain
    3 View Details [226..417] PSI-BLAST 27.69897 Glycosyltrehalose trehalohydrolase, N-terminal domain N; Glycosyltrehalose trehalohydrolase; Glycosyltrehalose trehalohydrolase, central domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • AMP-activated protein kinase activity
    		•  4.78975226545815 bayes_pls_golite062009
  • binding
    		•  2.65544526722793 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.69105818607475 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.66390525860632 bayes_pls_golite062009
  • kinase activity
    		•  1.64560031716993 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  1.62236890256061 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.53194692728729 bayes_pls_golite062009
  • protein binding
    		•  1.50286160643298 bayes_pls_golite062009
  • protein kinase activity
    		•  1.44964326848891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.39709424453076 bayes_pls_golite062009
  • transferase activity
    		•  1.26709925711174 bayes_pls_golite062009
  • cation channel activity
    		•  1.10928620793874 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.08920948133636 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  1.08920948133636 bayes_pls_golite062009
  • gated channel activity
    		•  0.9831902560942 bayes_pls_golite062009
  • ion channel activity
    		•  0.88499192552319 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.726369450752205 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.60798225319459 bayes_pls_golite062009
  • actin binding
    		•  0.54002000529721 bayes_pls_golite062009
  • enzyme binding
    		•  0.37496592438035 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle