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Protein Overview: MAS1

General Information:
Name(s) found: MAS1 / YLR163C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 462 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial processing peptidase complex [IDALink to PubMed article]
    Biological Process: protein processing involved in protein targeting to mitochondrion [IDALink to PubMed article]
    Molecular Function: mitochondrial processing peptidase activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSRTASKFR NTRRLLSTIS SQIPGTRTSK LPNGLTIATE YIPNTSSATV GIFVDAGSRA  60
   61 ENVKNNGTAH FLEHLAFKGT QNRSQQGIEL EIENIGSHLN AYTSRENTVY YAKSLQEDIP 120
  121 KAVDILSDIL TKSVLDNSAI ERERDVIIRE SEEVDKMYDE VVFDHLHEIT YKDQPLGRTI 180
  181 LGPIKNIKSI TRTDLKDYIT KNYKGDRMVL AGAGAVDHEK LVQYAQKYFG HVPKSESPVP 240
  241 LGSPRGPLPV FCRGERFIKE NTLPTTHIAI ALEGVSWSAP DYFVALATQA IVGNWDRAIG 300
  301 TGTNSPSPLA VAASQNGSLA NSYMSFSTSY ADSGLWGMYI VTDSNEHNVQ LIVNEILKEW 360
  361 KRIKSGKISD AEVNRAKAQL KAALLLSLDG STAIVEDIGR QVVTTGKRLS PEEVFEQVDK 420
  421 ITKDDIIMWA NYRLQNKPVS MVALGNTSTV PNVSYIEEKL NQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MAS1 MAS2
    View Details (MIPS) Mewes HW, et al. (2004) MAS1 MAS2
    View Details Krogan NJ, et al. (2006) ATG2 MAS1 MAS2
    View Details Gavin AC, et al. (2006) MAS1 MAS2
    View Details Gavin AC, et al. (2002) DIS3 ISW1 MAS1 MAS2 RRP4 SMC4
    View Details Ho Y, et al. (2002) MAS1 MAS2 MSH1 RNR3
    View Details Qiu et al. (2008) MAS1 MAS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MAS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155]
    [174..247]
    [387..411]    		 PSI-BLAST 10127.0 Mitochondrial processing peptidase (MPP) beta chain
    2 View Details [156..173]
    [248..386]
    [412..462]    		 PSI-BLAST 10127.0 Mitochondrial processing peptidase (MPP) beta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
    		•  10.0305725791312 bayes_pls_golite062009
  • ubiquinol-cytochrome-c reductase activity
    		•  10.0305725791312 bayes_pls_golite062009
  • metallopeptidase activity
    		•  7.31794755224524 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  7.31174048559335 bayes_pls_golite062009
  • peptidase activity
    		•  7.05972470989638 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  6.64269017601856 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.57226784092621 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  4.17510847735476 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.03221088799464 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.89224384280888 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.48526983761385 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.25021389096625 bayes_pls_golite062009
  • hydrolase activity
    		•  2.79262298779436 bayes_pls_golite062009
  • transporter activity
    		•  1.55442313420533 bayes_pls_golite062009
  • binding
    		•  1.51460850438647 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.40378628474509 bayes_pls_golite062009
  • catalytic activity
    		•  1.30647052031202 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29599547747567 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.16717310870379 bayes_pls_golite062009
  • signal transducer activity
    		•  1.12122807250795 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.12122807250795 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.05022391589259 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.961854978876222 bayes_pls_golite062009
  • protein binding
    		•  0.236143103582996 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.11486391789734 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.077701103001661 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0688257218639591 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0662171656580391 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle