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Protein Overview: SAR1

General Information:
Name(s) found: SAR1 / YPL218W [SGD]
Description(s) found:
Found 35 descriptions.
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  • GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 190 amino acids

    Gene Ontology:
    Cellular Component: COPII vesicle coat [TASLink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [TASLink to PubMed article]
    Molecular Function: GTPase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGWDIFGWF RDVLASLGLW NKHGKLLFLG LDNAGKTTLL HMLKNDRLAT LQPTWHPTSE  60
   61 ELAIGNIKFT TFDLGGHIQA RRLWKDYFPE VNGIVFLVDA ADPERFDEAR VELDALFNIA 120
  121 ELKDVPFVIL GNKIDAPNAV SEAELRSALG LLNTTGSQRI EGQRPVEVFM CSVVMRNGYL 180
  181 EAFQWLSQYI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) EMP24 ERP1 ERP2 ERV25 ERV46 SAR1 SEC13 SEC16 SEC23 SEC24 SEC31
    View Details Krogan NJ, et al. (2006) ARC15 ASR1 CAJ1 CDC7 CRN1 INP52 IRC22 MSK1 PNO1 PST2 RAD34 SAC6 SAR1 SLM1 TCP1 TED1 YPP1
    View Details Gavin AC, et al. (2006) ADE3 DPS1 FUR1 SAR1 TDH1 YDR341C YNK1
    View Details Ho Y, et al. (2002) BFR2 BIR1 BNA5 CDC15 CDC7 DUG2 ECM10 GCD11 JIP3 MCX1 NMD3 NUT1 PDC5 PDC6 PST2 RPC19 SAR1 SEC27 STI1 TEM1 THI3 TPS1 UBI4 VAC14 YHR033W YNK1
    View Details Qiu et al. (2008) APL4 ARF1 ARF2 COP1 EMP24 ERP1 ERP2 ERV25 SAR1 SEC13 SEC16 SEC21 SEC23 SEC24 SEC27 SEC28 SEC31 SEC4 SFB2 SFB3 YOS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen FAR10 SAR1 1 Unpublished Fields Lab Data
    View Screen RAD1 SAR1 1 Unpublished Fields Lab Data
    View Screen GDI1 SAR1 1 Unpublished Fields Lab Data
    View Screen RAD6 SAR1 1 Unpublished Fields Lab Data
    View Screen CDC23 SAR1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] PSI-BLAST 1122.154902 SAR1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • motor activity
    		•  3.3674051903467 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.9037759597776 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.51786963027655 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • actin binding
    		•  2.2973522188675 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
  • binding
    		•  2.21604035604783 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • alpha-tubulin binding
    		•  1.792591628112 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  1.77111739879769 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  1.75695995185278 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • GTPase activity
    		•  1.6309422514633 bayes_pls_golite062009
  • tubulin binding
    		•  1.62788446088451 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.51655225251251 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.49517431175162 bayes_pls_golite062009
  • signal recognition particle binding
    		•  1.46975774710831 bayes_pls_golite062009
  • microtubule binding
    		•  1.44471873069962 bayes_pls_golite062009
  • DNA binding
    		•  1.28683669571887 bayes_pls_golite062009
  • actin filament binding
    		•  1.28204719195916 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ATP binding
    		•  0.98146619596929 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.949788783884952 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.94708387424268 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.931486373329219 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.93133090558732 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.92105578610354 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.91827876091109 bayes_pls_golite062009
  • kinase activity
    		•  0.691112783105676 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • signal transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  0.585668369219566 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  0.53788302029845 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.499834566483656 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.38711726712063 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  0.305627755818843 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.267845390391521 bayes_pls_golite062009
  • protein kinase activity
    		•  0.214608777661308 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.208665086324262 bayes_pls_golite062009
  • transcription factor activity
    		•  0.139974763025221 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • beta-tubulin binding
    		•  0.115598037081252 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0430764033739892 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
  • dynein binding
    		•  0.00615444901942652 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle