YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	81 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
AAR2	U5 snRNP	assembly of spliceosomal tri-snRNP	molecular_function
BRR1	small nuclear ribonucleoprotein complex	spliceosome assembly	RNA binding
BUD31	nucleus	RNA splicing cellular bud site selection	molecular_function
CDC33	nucleus eukaryotic translation initiation factor 4F complex cytoplasm ribosome	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational initiation	translation initiation factor activity
CEF1	spliceosomal complex	nuclear mRNA splicing, via spliceosome	DNA binding first spliceosomal transesterification activity
CLF1	chromatin	DNA replication cell cycle cis assembly of pre-catalytic spliceosome nuclear mRNA splicing, via spliceosome	protein binding
CSN12	signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion	molecular_function
CUS1	U2 snRNP	spliceosome assembly	RNA binding protein binding
CWC2	spliceosomal complex	nuclear mRNA splicing, via spliceosome	molecular_function
CWC22	spliceosomal complex	nuclear mRNA splicing, via spliceosome	molecular_function
CWC23	spliceosomal complex	biological_process	molecular_function
DHH1	cytoplasm cytoplasmic mRNA processing body	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay deadenylation-dependent decapping of nuclear-transcribed mRNA	protein binding RNA helicase activity
DIB1	U4/U6 x U5 tri-snRNP complex U5 snRNP	nuclear mRNA splicing, via spliceosome	molecular_function
ECM2	nucleus	cellular cell wall organization nuclear mRNA splicing, via spliceosome	molecular_function
GCN2	cytosolic ribosome	cellular amino acid biosynthetic process regulation of translational initiation protein amino acid phosphorylation	protein kinase activity eukaryotic translation initiation factor 2alpha kinase activity
HSH155	U2 snRNP	spliceosome assembly	mRNA binding
HTA1	nuclear nucleosome	DNA repair chromatin assembly or disassembly	DNA binding
IMG1	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
LEA1	cytoplasm U2 snRNP	telomere maintenance nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
LIN1	nucleus U5 snRNP chromatin	biological_process	protein binding
LSM1	mRNA cap binding complex cytoplasmic mRNA processing body	deadenylation-dependent decapping of nuclear-transcribed mRNA mRNA catabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding RNA cap binding
LSM2	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LSM4	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LSM5	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LSM6	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LSM7	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	telomere maintenance mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LUC7	U1 snRNP	mRNA splice site selection	mRNA binding
MRP7	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome peptidyltransferase activity
MRPL28	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL3	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL35	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL38	mitochondrion mitochondrial large ribosomal subunit	telomere maintenance translation	structural constituent of ribosome
MRPL4	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL8	mitochondrion mitochondrial large ribosomal subunit	mitochondrial genome maintenance translation	structural constituent of ribosome
MRPS5	mitochondrion mitochondrial small ribosomal subunit	translation	structural constituent of ribosome
MSL1	U2 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
MUD1	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PAT1	cytoplasmic mRNA processing body	deadenylation-dependent decapping of nuclear-transcribed mRNA chromosome segregation regulation of translational initiation	molecular_function
PRP11	U2 snRNP	spliceosome assembly	RNA binding
PRP18	U4/U6 x U5 tri-snRNP complex spliceosomal complex	generation of catalytic spliceosome for second transesterification step nuclear mRNA splicing, via spliceosome	second spliceosomal transesterification activity
PRP19	nucleus cytoplasm mitochondrion spliceosomal complex	nuclear mRNA splicing, via spliceosome ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity first spliceosomal transesterification activity RNA binding
PRP21	U2 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP24	U6 snRNP	spliceosome assembly assembly of spliceosomal tri-snRNP	nucleic acid binding nucleotide binding U6 snRNA binding RNA binding snRNA binding
PRP28	U5 snRNP spliceosomal complex	RNA splicing mRNA processing cis assembly of pre-catalytic spliceosome	ATP-dependent RNA helicase activity
PRP3	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP31	mitochondrion U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
PRP38	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP39	commitment complex U1 snRNP	nuclear mRNA 5'-splice site recognition	pre-mRNA 5'-splice site binding
PRP4	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP40	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP42	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP43	mitochondrion spliceosomal complex nuclear outer membrane	maturation of SSU-rRNA ribosomal large subunit biogenesis ribosome biogenesis rRNA processing processing of 27S pre-rRNA	ATP-dependent RNA helicase activity
PRP46	spliceosomal complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP6	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	binding molecular_function
PRP8	U4/U6 x U5 tri-snRNP complex U5 snRNP	nuclear mRNA 3'-splice site recognition nuclear mRNA splicing, via spliceosome	U5 snRNA binding
PRP9	U2 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
RSE1	U2 snRNP	spliceosome assembly nuclear mRNA splicing, via spliceosome	U2 snRNA binding
RVB2	nucleus Swr1 complex Ino80 complex nuclear outer membrane chromatin remodeling complex	chromatin remodeling snoRNA metabolic process regulation of transcription from RNA polymerase II promoter	ATPase activity ATP-dependent 5'-3' DNA helicase activity
SLU7	spliceosomal complex	generation of catalytic spliceosome for second transesterification step	second spliceosomal transesterification activity
SMB1	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMD1	commitment complex U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SMD2	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMD3	commitment complex U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SME1	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMX2	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMX3	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SNP1	commitment complex U1 snRNP	nuclear mRNA splicing, via spliceosome	U1 snRNA binding mRNA binding
SNT309	spliceosomal complex	nuclear mRNA splicing, via spliceosome	protein binding
SNU114	U4/U6 x U5 tri-snRNP complex U5 snRNP	generation of catalytic spliceosome for first transesterification step nuclear mRNA splicing, via spliceosome	GTP binding U5 snRNA binding GTPase activity
SNU23	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	zinc ion binding metal ion binding molecular_function
SNU56	commitment complex U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SNU66	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SNU71	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
SPP381	U4/U6 x U5 tri-snRNP complex	generation of catalytic spliceosome for first transesterification step nuclear mRNA splicing, via spliceosome	protein binding
SPP382	nucleus cytoplasm mitochondrion spliceosomal complex	nuclear mRNA splicing, via spliceosome	RNA binding
SRB2	mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
STO1	commitment complex nuclear cap binding complex	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay telomere maintenance nuclear mRNA splicing, via spliceosome	mRNA binding
SYF1	spliceosomal complex	cell cycle nuclear mRNA splicing, via spliceosome	molecular_function
TOS4	nucleus cytoplasm mitochondrion	regulation of transcription involved in G1/S-phase of mitotic cell cycle	transcription factor activity
UTP21	nucleus nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	ribosome biogenesis	snoRNA binding
YML6	mitochondrion mitochondrial large ribosomal subunit	ribosomal large subunit assembly translation	structural constituent of ribosome

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
small nuclear ribonucleoprotein complex	4.8363E-77	81	63	45	6292
ribonucleoprotein complex	4.9337E-72	81	514	73	6292
U4/U6 x U5 tri-snRNP complex	9.8874E-41	81	32	24	6292
macromolecular complex	1.1868E-40	81	1635	77	6292
nuclear part	1.5246E-31	81	1103	62	6292
U1 snRNP	1.5055E-27	81	17	15	6292
spliceosomal complex	2.4019E-25	81	45	19	6292
U5 snRNP	1.354E-24	81	14	13	6292
intracellular organelle part	3.39E-24	81	2282	73	6292
organelle part	3.39E-24	81	2282	73	6292
nucleus	7.6882E-20	81	2041	66	6292
U2 snRNP	6.4797E-13	81	13	8	6292
membrane-bounded organelle	2.8857E-12	81	3771	76	6292
intracellular membrane-bounded organelle	2.8857E-12	81	3771	76	6292
intracellular organelle	5.6136E-12	81	4070	78	6292
organelle	5.7158E-12	81	4071	78	6292
U6 snRNP	1.6566E-9	81	11	6	6292
intracellular part	2.5932E-9	81	4938	81	6292
U2-type spliceosomal complex	3.2794E-9	81	12	6	6292
commitment complex	3.2794E-9	81	12	6	6292
intracellular	4.7706E-9	81	4975	81	6292
mitochondrial large ribosomal subunit	1.0087E-8	81	50	9	6292
organellar large ribosomal subunit	1.0087E-8	81	50	9	6292
mitochondrial ribosome	1.7644E-7	81	90	10	6292
organellar ribosome	1.7644E-7	81	90	10	6292
cell part	3.6731E-6	81	5397	81	6292
cell	3.7858E-6	81	5399	81	6292
large ribosomal subunit	1.0022E-5	81	110	9	6292
mitochondrial matrix	7.6453E-5	81	176	10	6292
mitochondrial lumen	7.6453E-5	81	176	10	6292
ribosomal subunit	1.0606E-4	81	183	10	6292
ribosome	2.9737E-4	81	290	12	6292
small nucleolar ribonucleoprotein complex	2.9985E-4	81	72	6	6292
cytoplasmic mRNA processing body	8.3654E-4	81	15	3	6292
RNA cap binding complex	2.3745E-3	81	6	2	6292
organelle lumen	3.7788E-3	81	660	17	6292
intracellular organelle lumen	3.7788E-3	81	660	17	6292
non-membrane-bounded organelle	3.8789E-3	81	959	22	6292
intracellular non-membrane-bounded organelle	3.8789E-3	81	959	22	6292
membrane-enclosed lumen	6.865E-3	81	700	17	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nuclear mRNA splicing, via spliceosome	1.622E-89	81	99	56	6292
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	3.6718E-89	81	100	56	6292
RNA splicing, via transesterification reactions	8.043E-87	81	107	56	6292
RNA splicing	2.9652E-82	81	132	57	6292
mRNA processing	6.6955E-75	81	156	56	6292
mRNA metabolic process	6.4243E-74	81	213	60	6292
RNA processing	7.5496E-54	81	380	58	6292
gene expression	1.1137E-43	81	1283	74	6292
RNA metabolic process	2.4935E-39	81	954	65	6292
nucleic acid metabolic process	7.0172E-31	81	1415	67	6292
cellular macromolecule metabolic process	1.7322E-29	81	2285	77	6292
macromolecule metabolic process	1.4139E-28	81	2349	77	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	4.7462E-28	81	1566	67	6292
cellular nitrogen compound metabolic process	8.6454E-26	81	1770	68	6292
nitrogen compound metabolic process	1.8453E-25	81	1791	68	6292
primary metabolic process	1.0032E-21	81	2896	77	6292
cellular metabolic process	3.1435E-20	81	3033	77	6292
metabolic process	6.1435E-19	81	3157	77	6292
spliceosome assembly	2.363E-17	81	18	11	6292
ribonucleoprotein complex assembly	8.3595E-16	81	92	17	6292
cellular macromolecular complex assembly	8.4072E-11	81	182	17	6292
cellular process	2.1424E-10	81	4426	79	6292
mRNA catabolic process	1.3038E-8	81	69	10	6292
cellular macromolecular complex subunit organization	1.994E-8	81	259	17	6292
RNA catabolic process	5.6332E-8	81	80	10	6292
macromolecular complex assembly	6.6833E-8	81	281	17	6292
ribonucleoprotein complex biogenesis	1.6222E-7	81	374	19	6292
macromolecular complex subunit organization	2.0315E-6	81	357	17	6292
nuclear mRNA cis splicing, via spliceosome	2.0561E-6	81	3	3	6292
spliceosomal conformational changes to generate catalytic conformation	3.0589E-6	81	9	4	6292
cellular component assembly	5.6895E-6	81	385	17	6292
mRNA splice site selection	3.9986E-5	81	6	3	6292
nuclear-transcribed mRNA catabolic process	1.1232E-4	81	38	5	6292
spliceosomal snRNP assembly	1.6371E-4	81	2	2	6292
cis assembly of pre-catalytic spliceosome	1.6371E-4	81	2	2	6292
assembly of spliceosomal tri-snRNP	1.6371E-4	81	2	2	6292
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	3.1486E-4	81	11	3	6292
deadenylation-dependent decapping of nuclear-transcribed mRNA	3.1486E-4	81	11	3	6292
generation of catalytic spliceosome for first transesterification step	4.8701E-4	81	3	2	6292
cellular macromolecule catabolic process	5.2881E-4	81	265	11	6292
translation	9.1938E-4	81	376	13	6292
cellular component biogenesis	1.0207E-3	81	694	19	6292
macromolecule catabolic process	1.2511E-3	81	294	11	6292
generation of catalytic spliceosome for second transesterification step	1.5963E-3	81	5	2	6292
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	4.8121E-3	81	27	3	6292
regulation of translational initiation	8.35E-3	81	11	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA binding	2.2759E-27	81	367	39	6292
nucleic acid binding	1.2325E-21	81	666	43	6292
binding	5.7711E-16	81	1294	50	6292
snRNA binding	3.1227E-10	81	5	5	6292
mRNA binding	9.4301E-9	81	35	8	6292
U5 snRNA binding	1.6371E-4	81	2	2	6292
structural constituent of ribosome	3.535E-4	81	212	10	6292
first spliceosomal transesterification activity	2.3745E-3	81	6	2	6292
second spliceosomal transesterification activity	3.2966E-3	81	7	2	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis