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Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur. The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. The cellular process by which a complex containing RNA and proteins is synthesized, aggregates, and bonds together. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: generation of catalytic spliceosome for second transesterification step
Acc: GO:0000350
Aspect: Biological Process
Desc: Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.
Synonyms:
  • formation of catalytic U2-type spliceosome for second transesterification step
  • spliceosomal A2-3 complex formation
  • GO:0000359
  • GO:0000358
  • spliceosomal C2 complex biosynthesis
  • formation of catalytic spliceosome for second transesterification step
  • formation of spliceosomal A2-2 complex
  • formation of spliceosomal C1 complex
  • catalytic spliceosome assembly for second transesterification step
  • lariat formation, 5'-splice site cleavage
  • spliceosomal C2 complex formation
  • formation of catalytic U12-type spliceosome for second transesterification step
  • spliceosomal A2-3 complex biosynthesis
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 14 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000350 - generation of catalytic spliceosome for second transesterification step (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle