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The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail. Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length. The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Acc: GO:0000288
Aspect: Biological Process
Desc: A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
Synonyms:
  • mRNA degradation, deadenylation-dependent decay
  • mRNA catabolic process, deadenylylation-dependent
  • mRNA breakdown, deadenylation-dependent decay
  • mRNA catabolism, deadenylylation-dependent
  • deadenylation-dependent mRNA decay
  • mRNA catabolic process, deadenylation-dependent
  • nuclear mRNA catabolic process, deadenylation-dependent decay
  • mRNA catabolism, deadenylation-dependent
Proteins in PDR annotated with:
   This term: 40 [Search]
   Term or descendants: 106 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle