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Protein Overview: P53_RAT

General Information:
Name(s) found: P53_RAT [Swiss-Prot]
Description(s) found:
Found 18 descriptions.
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  • Cellular tumor antigen p53 OS=Rattus norvegicus GN=Tp53 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 391 amino acids

    Gene Ontology:
    Cellular Component: nuclear body [UNKNOWN]
    PML body [UNKNOWN]
    endoplasmic reticulum [IEA]
    protein complex [UNKNOWN]
    nucleolus [UNKNOWN][ISS]
    chromatin [IDA]
    nucleoplasm [UNKNOWN]
    replication fork [UNKNOWN]
    nucleus [UNKNOWN][IDA][IEA][IMP][ISS]
    transcription factor complex [IDA]
    insoluble fraction [UNKNOWN]
    soluble fraction [IDA]
    transcription factor TFIID complex [UNKNOWN]
    cytoplasm [UNKNOWN][IMP][ISS]
    mitochondrion [UNKNOWN][IDA][ISS]
    cytosol [UNKNOWN][IDA]
    nuclear matrix [UNKNOWN]
    Biological Process: cell cycle arrest [UNKNOWN]
    response to hyperoxia [IEP]
    embryonic development ending in birth or egg hatching [UNKNOWN]
    transforming growth factor beta receptor signaling pathway [UNKNOWN]
    protein localization [UNKNOWN]
    T cell lineage commitment [UNKNOWN]
    nucleotide-excision repair [UNKNOWN][ISS]
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [UNKNOWN]
    response to retinoic acid [IEP]
    wound healing [IEP]
    negative regulation of neuroblast proliferation [UNKNOWN]
    in utero embryonic development [UNKNOWN]
    induction of apoptosis [UNKNOWN]
    negative regulation of cell growth [UNKNOWN][IEA][ISS][TAS]
    positive regulation of transcription, DNA-dependent [UNKNOWN]
    protein import into nucleus, translocation [UNKNOWN]
    apoptosis [UNKNOWN][ISS]
    regulation of cell cycle [UNKNOWN]
    response to gamma radiation [UNKNOWN]
    response to chemical stimulus [IEP]
    Ras protein signal transduction [UNKNOWN]
    regulation of apoptosis [UNKNOWN]
    negative regulation of DNA replication [UNKNOWN]
    response to organic cyclic substance [IEP]
    response to DNA damage stimulus [UNKNOWN]
    activation of caspase activity by cytochrome c [UNKNOWN][ISS]
    regulation of mitochondrial membrane permeability [UNKNOWN]
    cellular response to glucose starvation [UNKNOWN]
    positive regulation of leukocyte migration [IMP]
    regulation of intracellular pH [IMP]
    B cell lineage commitment [UNKNOWN]
    central nervous system development [UNKNOWN]
    somitogenesis [UNKNOWN]
    release of cytochrome c from mitochondria [UNKNOWN]
    DNA damage response, signal transduction by p53 class mediator [UNKNOWN]
    response to cytokine stimulus [IEP]
    multicellular organism growth [UNKNOWN]
    response to X-ray [UNKNOWN][IEP]
    response to salt stress [UNKNOWN]
    protein complex assembly [UNKNOWN]
    multicellular organismal development [UNKNOWN][ISS]
    positive regulation of histone deacetylation [UNKNOWN]
    negative regulation of cell proliferation [UNKNOWN]
    response to amino acid stimulus [IEP]
    positive regulation of cell cycle [IMP]
    positive regulation of transcription [UNKNOWN]
    response to UV [UNKNOWN][IEP]
    regulation of neuron apoptosis [UNKNOWN]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    ER overload response [UNKNOWN]
    positive regulation of neuron apoptosis [UNKNOWN]
    double-strand break repair [UNKNOWN]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [UNKNOWN]
    response to oxidative stress [IEP]
    negative regulation of fibroblast proliferation [UNKNOWN]
    negative regulation of smooth muscle cell proliferation [IMP]
    cellular response to UV [UNKNOWN]
    response to metal ion [IEP]
    response to vitamin B3 [IEP]
    response to inorganic substance [IEP]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN][IDA]
    G1/S DNA damage checkpoint [UNKNOWN]
    T cell differentiation in the thymus [UNKNOWN]
    rRNA transcription [UNKNOWN]
    regulation of transcription, DNA-dependent [UNKNOWN][IEA]
    aging [IEP]
    cell aging [UNKNOWN][ISS]
    regulation of cell proliferation [UNKNOWN]
    regulation of transcription from RNA polymerase II promoter [TAS]
    gastrulation [UNKNOWN]
    response to tumor cell [IEA]
    chromosome organization [UNKNOWN]
    response to drug [UNKNOWN][IEP]
    negative regulation of apoptosis [UNKNOWN]
    positive regulation of apoptosis [UNKNOWN][IMP]
    T cell proliferation during immune response [UNKNOWN]
    response to caffeine [IEP]
    response to organic nitrogen [IEP]
    negative regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN]
    Molecular Function: histone deacetylase regulator activity [UNKNOWN]
    zinc ion binding [IEA]
    DNA strand annealing activity [UNKNOWN][ISS]
    protein C-terminus binding [IPI]
    sequence-specific DNA binding [IDA]
    chromatin binding [UNKNOWN]
    transcription factor binding [UNKNOWN]
    DNA binding [UNKNOWN][ISS]
    ATP binding [UNKNOWN][ISS]
    transcription factor activity [UNKNOWN][IEA]
    protein binding [UNKNOWN][IPI]
    ubiquitin protein ligase binding [IPI]
    RNA polymerase II transcription factor activity [TAS]
    copper ion binding [UNKNOWN][ISS]
    metal ion binding [IEA]
    protein heterodimerization activity [UNKNOWN]
    protein N-terminus binding [UNKNOWN]
    chaperone binding [UNKNOWN]
    promoter binding [UNKNOWN]
    transcription activator activity [UNKNOWN]
    transcription repressor activity [IDA]
    enzyme binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDSQSDMSI ELPLSQETFS CLWKLLPPDD ILPTTATGSP NSMEDLFLPQ DVAELLEGPE  60
   61 EALQVSAPAA QEPGTEAPAP VAPASATPWP LSSSVPSQKT YQGNYGFHLG FLQSGTAKSV 120
  121 MCTYSISLNK LFCQLAKTCP VQLWVTSTPP PGTRVRAMAI YKKSQHMTEV VRRCPHHERC 180
  181 SDGDGLAPPQ HLIRVEGNPY AEYLDDRQTF RHSVVVPYEP PEVGSDYTTI HYKYMCNSSC 240
  241 MGGMNRRPIL TIITLEDSSG NLLGRDSFEV RVCACPGRDR RTEEENFRKK EEHCPELPPG 300
  301 SAKRALPTST SSSPQQKKKP LDGEYFTLKI RGRERFEMFR ELNEALELKD ARAAEESGDS 360
  361 RAHSSYPKTK KGQSTSRHKK PMIKKVGPDS D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle