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Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. The morphological and physiological alterations undergone by mitochondria during apoptosis. Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. The process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: release of cytochrome c from mitochondria
Acc: GO:0001836
Aspect: Biological Process
Desc: The process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
Proteins in PDR annotated with:
   This term: 47 [Search]
   Term or descendants: 47 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001836 - release of cytochrome c from mitochondria (interactive image map)
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