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The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. The process by which an immature B cell becomes committed to become a B-1 B cell. The process whereby a precursor cell type acquires the specialized features of a B cell. The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells. A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. The process whereby a lymphoid progenitor cell becomes committed to become any type of B cell. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

View Gene Ontology (GO) Term


Name: B cell lineage commitment
Acc: GO:0002326
Aspect: Biological Process
Desc: The process whereby a lymphoid progenitor cell becomes committed to become any type of B cell.
  • B-cell lineage commitment
  • B lymphocyte lineage commitment
  • B-lymphocyte lineage commitment
Proteins in PDR annotated with:
   This term: 18 [Search]
   Term or descendants: 18 [Search]


GO:0002326 - B cell lineage commitment (interactive image map)

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