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Protein Overview: hop-PA

General Information:
Name(s) found: hop-PA / FBpp0073313 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene hopscotch is referred to in FlyBase by the symbol Dmel\hop (CG1594, FBgn0004864). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11254932..11262130. It has the cytological map location 10B5-10B6. Based on sequence similarity, it is predicted to have molecular function</span>: Janus kinase activity. There is experimental evidence for 21 unique biological process</span> terms, many of which group under: anatomical structure development; sensory organ development; reproductive process in a multicellular organism; organ morphogenesis; regulation of developmental process; embryonic pattern specification; regulation of biological process; ovarian follicle cell development; regionalization; establishment of planar polarity. 71 alleles are reported. The phenotypes of these alleles are annotated with 51 unique terms, many of which group under: organ system; female germline cyst; embryonic/larval hemocoel; abdominal ventral denticle belt; hemocyte; external compound sense organ; adult segment; peripheral nervous system; nervous system; adult mesothoracic segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1177 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEA]
    cytoplasm [NAS][TAS]
    Biological Process: cell proliferation [IMP]
    hemopoiesis [TAS]
    blastoderm segmentation [IMP][TAS]
    imaginal disc-derived wing morphogenesis [NAS]
    nervous system development [IMP]
    cytokinesis [TAS]
    germ-line stem cell division [TAS]
    eye-antennal disc morphogenesis [IMP]
    border follicle cell migration [IMP][TAS]
    sex determination [NAS]
    protein amino acid phosphorylation [IEA][NAS]
    JAK-STAT cascade [IGI][ISS][NAS][TAS]
    immune response [TAS]
    somatic stem cell division [TAS]
    ovarian follicle cell development [IMP]
    humoral immune response [TAS]
    defense response to virus [IMP]
    tyrosine phosphorylation of STAT protein [TAS]
    imaginal disc-derived leg morphogenesis [NAS]
    stem cell maintenance [IMP]
    ommatidial rotation [IMP]
    hemocyte proliferation [TAS]
    encapsulation of foreign target [NAS]
    STAT protein nuclear translocation [TAS]
    regulation of hemocyte differentiation [IMP]
    establishment of ommatidial planar polarity [IMP]
    hemocyte differentiation [IMP]
    periodic partitioning [IMP]
    hindgut morphogenesis [IMP]
    lamellocyte differentiation [TAS]
    equator specification [IMP]
    defense response [NAS]
    compound eye development [IMP]
    open tracheal system development [IMP]
    compound eye photoreceptor cell differentiation [IMP]
    cellular defense response [NAS]
    primary sex determination [IMP]
    ovarian follicle cell stalk formation [IMP]
    oogenesis [TAS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [NAS]
    protein binding [IEA]
    non-membrane spanning protein tyrosine kinase activity [NAS]
    Janus kinase activity [ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALANGGEDR MDDSSSGRTS LADSASLTNS SLRSGTSSQS IHTNDGTIRV FNFTTGEFER  60
   61 FHPNMLCEEI CNTMCRQLGI APIAQLLYGI REHSTSRRPS PLVRLDLTWC LPGERLNCQL 120
  121 VYCFRMRFRV PELDSQLELI DGRSHKFLYR QMRYDMRTEQ IPEIRYPEHK DKSTGLAVMD 180
  181 MLIDDQEQSE DQQAMRSIEK LYKLYLPPSL WRAHSFFVGS KIREVFRSLK ANSLSVERLK 240
  241 WHYVHQVSHL APTYMTEQFT CTVQYLPNEE VARGSGPIGT SLAHSTSTLA SSGSTNTLST 300
  301 LTTNTNSVAL GGSGKKAKRR STSGGIDVYV RVFPHDSLEP GLKVARVTSE ATLKWILVGA 360
  361 VEGIFMISKI NDTSVRLEIV GLPKGYEMQF QTEKEMKSFI SYLGIYIRLS SKWMQDLCHS 420
  421 YRTPSLEELS SLHCHGPIGG AYSLMKLHEN GDKCGSYIVR ECDREYNIYY IDINTKIMAK 480
  481 KTDQERCKTE TFRIVRKDSQ WKLSYNNGEH VLNSLHEVAH IIQADSPDRY RIPASKYDKP 540
  541 PLLLLLLPKN LKAKKTDLQL SEAELQRRNP QIFNPRTDLQ WYPDSISLSD DGMMFTMRGD 600
  601 WIQQSPVKDV SVTMKMLKSD GNFMEFFRLA QTWSLIQSPQ FLKLYGLTLA DPYTMVMEYS 660
  661 RYGPLNKFLH SMPNVTLHCL LDLMHGLVRG MHYLEDNKII HNYIRCSNLY VTKYDPNSYV 720
  721 LDAKISDPGY PRPYRESDSP WIPVKYYRNL QAAKTDQFAQ LWAFATTIYE IFSRCKEDLS 780
  781 TLRQEQLLRQ KNLDGNILKM LDQDICPAPI FETIMDGWSD DETKRFSHHD IFSRLNTIKA 840
  841 EILPNYMPPP EIATNGTGDE TVIDRSDIPF LPFPRSNMLM VIPLTSECRV IYNMENMIGR 900
  901 GHYGTVYKGH LEFNDKDQPR EQVAIKMLNT MQVSTDFHRE IGIMRTLSHP NIVKFKYWAE 960
  961 KSHCIIMEYL QSGSFDIYLR FTAPNLNNPR LVSFALDIAN GMKYLSDMGL IHRDLAARNI1020
 1021 LVDHNGDGDC VKISDFGLAQ FANSDGYYYA KSKRDIPIRW YSPEAISTCR FSSYSDVWSY1080
 1081 GVTLFEMFSR GEEPNLVPIQ TSQEDFLNRL QSGERLNRPA SCPDFIYDLM QLCWHATPRS1140
 1141 RPSFATIVDI ITREVATKVT HPTDGHQSPP NQPTDAE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..284] FFAS03 4.44 FERM domain of Focal Adhesion Kinase
    2 View Details [285..866] PSI-BLAST 117.0 No description for 2h8hA was found.
    3 View Details [867..1177] PSI-BLAST 74.69897 No description for 2qoqA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  2.78014377544701 bayes_pls_golite062009
  • binding
    		•  2.70872150536621 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.35453941832029 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23822335492051 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.06339025620966 bayes_pls_golite062009
  • DNA binding
    		•  1.8833926783115 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.71711303358304 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.65143775864899 bayes_pls_golite062009
  • kinase activity
    		•  1.63779463482357 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.53011388333584 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42846875539579 bayes_pls_golite062009
  • transferase activity
    		•  1.27638139677762 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.18258299713791 bayes_pls_golite062009
  • actin binding
    		•  1.12812097171372 bayes_pls_golite062009
  • signal transducer activity
    		•  1.07208466109379 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.07208466109379 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.67884592236589 bayes_pls_golite062009
  • tubulin binding
    		•  0.296026215424798 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.172760623576326 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.156922202244152 bayes_pls_golite062009
  • enzyme binding
    		•  0.147520546067615 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.0883890683408073 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0623044995795676 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0437862640556833 bayes_pls_golite062009
  • receptor binding
    		•  0.00986014111393829 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • insulin receptor activity
    		•  3.20786175773448 bayes_pls_golite062009
  • PTB domain binding
    		•  2.97926451113784 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.69208419195971 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  2.18795259566024 bayes_pls_golite062009
  • phosphatase activity
    		•  2.10545147905564 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.06076411916645 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.57005671465985 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • growth hormone receptor binding
    		•  1.56531632362906 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • insulin binding
    		•  1.23861703046323 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  1.07927533779326 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  0.878815317889563 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  0.856861384729301 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.705067960165986 bayes_pls_golite062009
  • transcription activator activity
    		•  0.645254722299306 bayes_pls_golite062009
  • Janus kinase activity
    		•  0.580310109637219 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.546647574638943 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.505233004492768 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  0.384048681536292 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.284465446035567 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  0.272902474317891 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.240883589532225 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • actin binding
    		•  0.144822861207099 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • cation binding
    		•  0.046173055856133 bayes_pls_golite062009
  • metal ion binding
    		•  0.046173055856133 bayes_pls_golite062009
  • ion binding
    		•  0.0389662058697694 bayes_pls_golite062009
  • nitric-oxide synthase regulator activity
    		•  0.00407218246327123 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle