Protein Overview: RXT2

General Information:
Name(s) found:	RXT2 / YBR095C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|37362619\|ref\|NP_009653.2\| Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; Rxt2p [Saccharomyces cerevisiae] [NCBI NR] gi\|108935903\|sp\|P38255.2\|RXT2_YEAST RecName: Full=Transcriptional regulatory protein RXT2 [NCBI NR] Transcriptional regulatory protein RXT2 OS=Saccharomyces cerevisiae GN=RXT2 PE=1 SV=2 [Swiss-Prot] RXT2 Nuclear protein with role in cellular fusion and invasive growth [mips] Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth [SGD] Chr II from 435654-434362, reverse complement [yeastorf5.fasta] RXT2 SGDID:S0000299, Chr II from 435655-434363, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] RXT2 SGDID:S0000299, Chr II from 435692-434400, reverse complement, Uncharacterized ORF [10112005cervSGD.fasta] Rxt2p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] YBR095C SGDID:S000000299, Chr II from 435692-434400, reverse complement, Uncharacterized ORF, "Protein possibly involved in cell fusion and invasive growth" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] RXT2 SGDID:S000000299, Chr II from 435692-434400, reverse complement, Verified ORF, "Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth" [yeast-contam.fasta] Transcriptional regulatory protein RXT2 [nr-271106-contam.fasta] Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; Rxt2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Transcriptional regulatory protein RXT2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RXT2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] RXT2 SGDID:S000000299, Chr II from 435698-434406, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth" [yeast-030211-contam.fasta] RXT2 SGDID:S000000299, Chr II from 435698-434406, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia" [20141208_orf_trans.fasta] YBR095C SGDID:S000000299, Chr II from 435698-434406, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	430 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA]
Biological Process:	negative regulation of transcription from RNA polymerase II promoter [IMP] conjugation with cellular fusion [IMP] invasive growth in response to glucose limitation [IMP] histone deacetylation [IDA ]
Molecular Function:	histone deacetylase activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIRSSMKNN AELESKSVLA NESNIISTFT RRIIKEKSGN YQVLKRSLDG KLIYPEATGI  60
   61 SSNRGNKLLQ RSEVVTRRDL NNSKPMIEQT VFYNGSEHRL LQTNIVTDSR RKRIKFTPDI 120
  121 NVEPVLVGDE NDIDGSEKED ENITDEYYGE EDDDDLSKLV NVKEILTPIL SLGDIINHKT 180
  181 ISRTFSSPIL KNLALQIILM IEKEQMSVVR YSQFLEVFLG DHPEPIYESN LNLPSYNHNL 240
  241 TLPEDRGASD EDDINNKNNI NEVNSNSLST EAGHINNGME EFGEEDPFFA LPRLEQSNAL 300
  301 LSLLPSSSGS ASISTLTAAE QQQLNEEIES ARQLSQIALQ RNKEFIRNLQ KIRKSVIKAN 360
  361 RIRGRILNWS REYLGISDDD ITIPVALRVV KRGLISATTN KTTNFEEEIE NTMEDGVVDD 420
  421 NEPDEEANRA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CTI6 DEP1 EAF3 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SDS3 SIN3 UME1
View Details	Krogan NJ, et al. (2006)		ASH1 COQ6 CTI6 DEP1 EAF3 GRX5 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SAY1 SDS3 SIN3 UME1
View Details	Gavin AC, et al. (2002)		ABF2 CKA1 CKA2 CKB1 CKB2 CTI6 DEP1 DOT6 EAF3 ECM16 HTA2 IOC3 ISW1 MED4 NHP10 NRD1 PHO23 RCO1 RPD3 RSC8 RXT2 RXT3 SAP30 SDS3 SIN3 STO1 TOP1 TUP1 UME1 UME6 VPS1
View Details	Qiu et al. (2008)		HST1 PHO23 RPD3 RXT2 SAP30 SIF2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YOR203W	RXT2	1	Unpublished Fields Lab Data
View Screen	CIA1	RXT2	1	Hazbun TR, et al. (2003)
View Screen	RGD2	RXT2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RXT2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..148]	deduced	N/A	No confident structure predictions are available.
2	View Details	[149..242]	MSA	1.008974	View MSA. No confident structure predictions are available.
3	View Details	[243..430]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2