Protein Overview: IPL1

General Information:
Name(s) found:	IPL1 / YPL209C [SGD]
Description(s) found: Found 31 descriptions. SHOW ALL	Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase [SGD]
Organism:	Saccharomyces cerevisiae
Length:	367 amino acids
Gene Ontology:
Cellular Component:	spindle microtubule [IDA ] spindle midzone [IDA] kinetochore microtubule [IDA] spindle [IDA] condensed nuclear chromosome kinetochore [IDA ]
Biological Process:	attachment of spindle microtubules to kinetochore [IMP] chromosome segregation [IMP] mitotic spindle disassembly [IMP]
Molecular Function:	protein kinase activity [IDA ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRNSLVNIK LNANSPSKKT TTRPNTSRIN KPWRISHSPQ QRNPNSKIPS PVREKLNRLP  60
   61 VNNKKFLDME SSKIPSPIRK ATSSKMIHEN KKLPKFKSLS LDDFELGKKL GKGKFGKVYC 120
  121 VRHRSTGYIC ALKVMEKEEI IKYNLQKQFR REVEIQTSLN HPNLTKSYGY FHDEKRVYLL 180
  181 MEYLVNGEMY KLLRLHGPFN DILASDYIYQ IANALDYMHK KNIIHRDIKP ENILIGFNNV 240
  241 IKLTDFGWSI INPPENRRKT VCGTIDYLSP EMVESREYDH TIDAWALGVL AFELLTGAPP 300
  301 FEEEMKDTTY KRIAALDIKM PSNISQDAQD LILKLLKYDP KDRMRLGDVK MHPWILRNKP 360
  361 FWENKRL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		CYS3 IPL1 RAX2 SER1 UBA1 YDR415C YER156C
View Details	Qiu et al. (2008)		DAD3 DAD4 HSK3 IPL1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	DAD1	No Comments	Cheeseman IM, et al. (2002)
View Run	IPL1	No Comments	Cheeseman IM, et al. (2002)
View Run	SLI15	No Comments	Cheeseman IM, et al. (2002)
View Run	TID3	No Comments	Cheeseman IM, et al. (2002)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	IPL1	LPX1	2	Unpublished Fields Lab Data
View Screen	IPL1	GCD11	1	Unpublished Fields Lab Data
View Screen	IPL1	ADK2	1	Unpublished Fields Lab Data
View Screen	IPL1	BNA6	1	Unpublished Fields Lab Data
View Screen	IPL1	YGR022C	1	Unpublished Fields Lab Data
View Screen	IPL1	TDH3	1	Unpublished Fields Lab Data
View Screen	IPL1	PPE1	1	Unpublished Fields Lab Data
View Screen	IPL1	YJR111C	1	Unpublished Fields Lab Data
View Screen	IPL1	YNR005C	1	Unpublished Fields Lab Data
View Screen	IPL1	PDR18	1	Unpublished Fields Lab Data
View Screen	PRP42	IPL1	1	Unpublished Fields Lab Data
View Screen	IPL1	VTS1	1	Unpublished Fields Lab Data
View Screen	UBI4	IPL1	1	Unpublished Fields Lab Data
View Screen	UBC7	IPL1	1	Unpublished Fields Lab Data
View Screen	SPT21	IPL1	1	Unpublished Fields Lab Data
View Screen	IPL1	ROX3	1	Unpublished Fields Lab Data
View Screen	IPL1	IML3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	IPL1	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..75]	deduced	N/A	Confident ab initio structure predictions are available.
2	View Details	[76..153] [167..183]	PSI-BLAST	582.0103	cAMP-dependent PK, catalytic subunit
3	View Details	[154..166] [184..367]	PSI-BLAST	582.0103	cAMP-dependent PK, catalytic subunit

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.24008660655062	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	4.93501454706421	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.63692708178478	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
telethonin binding	3.3248469696008	bayes_pls_golite062009
transferase activity	3.26787750561728	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
alpha-actinin binding	2.44115606050549	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
actinin binding	2.0444694493411	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
actin binding	1.33479685165255	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.20800936400261	bayes_pls_golite062009
receptor signaling protein activity	1.13658159660305	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
transporter activity	0.553953601841147	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.51726292539973	bayes_pls_golite062009
nucleic acid binding	0.444972929276369	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
transmembrane transporter activity	0.37676337669549	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
MAP kinase activity	0.26024936404169	bayes_pls_golite062009
gamma-tubulin binding	0.242410242748222	bayes_pls_golite062009
actin filament binding	0.2403700250846	bayes_pls_golite062009
transcription regulator activity	0.222474717779546	bayes_pls_golite062009
DNA binding	0.198054762876122	bayes_pls_golite062009
substrate-specific transporter activity	0.0611721261859464	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.0556163711947139	bayes_pls_golite062009
transcription factor activity	0.026050048647416	bayes_pls_golite062009
transmembrane receptor activity	0.00652065412910241	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2