YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: IPL1
Organism: Saccharomyces cerevisiae
Length: 367 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IPL1.

Description E-value Query
Range
Subject
Range
gi|45384254, gi|... - gi|45384254|ref|NP_990386.1| AKT1 kinase [Gallus gallus], gi|2745889|gb|AAB94767.1| serine/threonine...
0.0 [2..364] [47..415]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [2..364] [330..698]
AKT_MLVAT - AKT kinase-transforming protein OS=AKT8 murine leukemia virus GN=V-AKT PE=1 SV=1
0.0 [2..364] [68..436]
AKT1_RAT - RAC-alpha serine/threonine-protein kinase OS=Rattus norvegicus GN=Akt1 PE=1 SV=1
0.0 [2..364] [47..415]
AKT1_MOUSE - RAC-alpha serine/threonine-protein kinase OS=Mus musculus GN=Akt1 PE=1 SV=2
gi|117616188, gi... - gi|117616190|gb|ABK42113.1| AKT [synthetic construct], gi|117616188|gb|ABK42112.1| Akt1 [synthetic c...
0.0 [2..364] [47..415]
AKT2 - v-akt murine thymoma viral oncogene homolog 2
0.0 [2..364] [47..416]
PK2_DICDI - Protein kinase 2 - Dictyostelium discoideum (Slime mold)
0.0 [2..365] [54..415]

Back

Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRNSLVNIK LNANSPSKKT TTRPNTSRIN KPWRISHSPQ QRNPNSKIPS PVREKLNRLP  60
   61 VNNKKFLDME SSKIP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.567 0.880 chromosome segregation a.4.5 "Winged helix" DNA-binding domain

Predicted functions:

Term Confidence Notes
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.24008660655062 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 4.93501454706421 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.63692708178478 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
telethonin binding 3.3248469696008 bayes_pls_golite062009
transferase activity 3.26787750561728 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
alpha-actinin binding 2.44115606050549 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
actinin binding 2.0444694493411 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.20800936400261 bayes_pls_golite062009
receptor signaling protein activity 1.13658159660305 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.553953601841147 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.51726292539973 bayes_pls_golite062009
nucleic acid binding 0.444972929276369 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
transmembrane transporter activity 0.37676337669549 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
MAP kinase activity 0.26024936404169 bayes_pls_golite062009
gamma-tubulin binding 0.242410242748222 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
transcription regulator activity 0.222474717779546 bayes_pls_golite062009
DNA binding 0.198054762876122 bayes_pls_golite062009
substrate-specific transporter activity 0.0611721261859464 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transcription factor activity 0.026050048647416 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [76-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPIRKATSSK MIHENKKLPK FKSLSLDDFE LGKKLGKGKF GKVYCVRHRS TGYICALKVM  60
   61 EKEEIIKYNL QKQFRREV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [167-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYGYFHDEKR VYLLMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 582.0103
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [154-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EIQTSLNHPN LTK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [184-367]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVNGEMYKLL RLHGPFNDIL ASDYIYQIAN ALDYMHKKNI IHRDIKPENI LIGFNNVIKL  60
   61 TDFGWSIINP PENRRKTVCG TIDYLSPEMV ESREYDHTID AWALGVLAFE LLTGAPPFEE 120
  121 EMKDTTYKRI AALDIKMPSN ISQDAQDLIL KLLKYDPKDR MRLGDVKMHP WILRNKPFWE 180
  181 NKRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 582.0103
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle