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Protein Overview: HHO1

General Information:
Name(s) found: HHO1 / YPL127C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 258 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    nuclear nucleosome [IPILink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IMPLink to PubMed article]
    negative regulation of DNA recombination [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: DNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPKKSTTKT TSKGKKPATS KGKEKSTSKA AIKKTTAKKE EASSKSYREL IIEGLTALKE  60
   61 RKGSSRPALK KFIKENYPIV GSASNFDLYF NNAIKKGVEA GDFEQPKGPA GAVKLAKKKS 120
  121 PEVKKEKEVS PKPKQAATSV SATASKAKAA STKLAPKKVV KKKSPTVTAK KASSPSSLTY 180
  181 KEMILKSMPQ LNDGKGSSRI VLKKYVKDTF SSKLKTSSNF DYLFNSAIKK CVENGELVQP 240
  241 KGPSGIIKLN KKKVKLST

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HHO1 NHP6A PWP1 RPL32 RPL6A RPS16B, RPS16A RPS17B
    View Details Krogan NJ, et al. (2006) CPR7 GBP2 GVP36 HHO1 HPR1 HRB1 MFT1 SUB2 TEX1 THO2 THP2 ULS1 YNL140C
    View Details Ho Y, et al. (2002) AI1 CDC5 FUN12 HHF1, HHF2 HHO1 ICP55 IMD2 IMD3 IMD4 LOC1 MAG1 MGM101 MPH1 MSH2 MUS81 NOP12 NUG1 RET1 RPC82 TAF14 TIF4631 TIF4632 TMA29 UTP22 YRA1
    View Details Qiu et al. (2008) FPR4 HHO1 PCC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HHO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] PSI-BLAST 14.0 Histone H5, globular domain
    2 View Details [143..258] MSA 7.083996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.835523092977445 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.4843036104266 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.37117756729668 bayes_pls_golite062009
  • DNA binding
    		•  0.3118855114645 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  0.835523092977445 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.4843036104266 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.37117756729668 bayes_pls_golite062009
  • DNA binding
    		•  0.3118855114645 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle