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Protein Overview: SEN54

General Information:
Name(s) found: SEN54 / YPL083C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 467 amino acids

    Gene Ontology:
    Cellular Component: nuclear inner membrane [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    tRNA-intron endonuclease complex [TASLink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: tRNA splicing, via endonucleolytic cleavage and ligation [TASLink to PubMed article]
    Molecular Function: tRNA-intron endonuclease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQFAGKKTDQ VTTSNPGFEE EEEEEEELQQ DWSQLASLVS KNAALSLPKR GEKDYEPDGT  60
   61 NLQDLLLYNA SKAMFDTISD SIRGTTVKSE VRGYYVPHKH QAVLLKPKGS FMQTMGRADS 120
  121 TGELWLDFHE FVYLAERGTI LPYYRLEAGS NKSSKHETEI LLSMEDLYSL FSSQQEMDQY 180
  181 FVFAHLKRLG FILKPSNQEA AVKTSFFPLK KQRSNLQAIT WRLLSLFKIQ ELSLFSGFFY 240
  241 SKWNFFFRKY TTSPQLYQGL NRLVRSVAVP KNKKELLDAQ SDREFQKVKD IPLTFKVWKP 300
  301 HSNFKKRDPG LPDFQVFVYN KNDDLQHFPT YKELRSMFSS LDYKFEFLSE IEDDDDWETN 360
  361 SYVEDIPRKE YIHKRSAKSQ TEKSESSMKA SFQKKTAQSS TKKKRKAYPP HIQQNRRLKT 420
  421 GYRSFIIAIM DNGLISFVKM SEADFGSESV WYTPNTQKKV DQRWKKH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LOS1 SEN15 SEN2 SEN34 SEN54 STP1 STP2 STP3 STP4 TPT1 TRL1
    View Details Gavin AC, et al. (2006) SEN54 TUF1 VAC14
    View Details Gavin AC, et al. (2002) CLU1 CRN1 ECM29 KAP123 MEC1 MIP6 MIS1 MRPL23 NAB3 NAB6 NRD1 ROM2 RPA135 SEN54 SUI3 SUP35 SUP45 TAO3 USO1 UTP20 VAC14 VPS5 YJL017W
    View Details Qiu et al. (2008) SEN15 SEN2 SEN34 SEN54 TRL1 TRM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEN54 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..381] MSA 3.011962 View MSA. No confident structure predictions are available.
    2 View Details [382..467] deduced N/A No confident structure predictions are available.
    3 View Details [207..328] deduced N/A No confident structure predictions are available.
    4 View Details [329..467] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle