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Protein Overview: FRE3

General Information:
Name(s) found: FRE3 / YOR381W [SGD]
Description(s) found:
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  • gi|6324957|ref|NP_015026.1| Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; Fre3p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|3913674|sp|Q08905.1|FRE3_YEAST RecName: Full=Ferric reductase transmembrane component 3; AltName: Full=Ferric-chelate reductase 3; Flags: Precursor [NCBI NR]
  • pir||S67293 probable membrane protein YOR381w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420821|emb|CAA99713.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae GN=FRE3 PE=1 SV=1 [Swiss-Prot]
  • FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters, expression induced by low iron levels [mips]
  • Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels [SGD]
  • (Q08905) Ferric reductase transmembrane component 3 precursor (EC 1.16.1.7) (Ferric-chelate reductase 3) [4932.FASTACCERV.txt]
  • Chr XV from 1055539-1057674 [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 1055538-1057673 [yeastorf3.fasta]
  • FRE3, Chr XV from 1055538-1057673 [yeast_orfs2]
  • FRE3 SGDID:S0005908, Chr XV from 1055541-1057676, Verified ORF [yeastflysequest.fasta]
  • Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels [Saccharomyces cerevisiae]gi|1420821|emb|CAA99713.1| unnamed protein product [Saccharomyces cerevisiae]gi|2132959|pir||S67293 probabl [nrdb_11152004_Chlamydomonas]
  • FRE3 SGDID:S000005908, Chr XV from 1055541-1057676, Verified ORF, "Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • FRE3 SGDID:S000005908, Chr XV from 1055543-1057678, Verified ORF, "Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [yeast-contam.fasta]
  • Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; Fre3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ferric reductase transmembrane component 3 precursor (Ferric-chelate reductase 3) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • FRE3 SGDID:S000005908, Chr XV from 1055545-1057680, Genome Release 64-1-1, Verified ORF, "Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [yeast-030211-contam.fasta]
  • FRE3 SGDID:S000005908, Chr XV from 1055545-1057680, Genome Release 64-2-1, Verified ORF, "Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [20141208_orf_trans.fasta]
  • YOR381W SGDID:S000005908, Chr XV from 1055545-1057680, Genome Release 64-1-1, Verified ORF, "Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 711 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISSLink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IEPLink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    siderophore-iron transport [IMPLink to PubMed article]
    Molecular Function: ferric-chelate reductase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYWVLLCGSI LLCCLSGASA SPAKTKMYGK LPLVLTDACM GVLGEVTWEY SSDDLYSSPA  60
   61 CTYEPALQSM LYCIYESLNE KGYSNRTFEK TFAAIKEDCA YYTDNLQNMT NADFYNMLNN 120
  121 GTTYIIQYSE GSANLTYPIE MDAQVRENYY YSYHGFYANY DIGHTYGGII CAYFVGVMIL 180
  181 ASILHYLSYT PFKTALFKQR LVRYVRRYLT IPTIWGKHAS SFSYLKIFTG FLPTRSEGVI 240
  241 ILGYLVLHTV FLAYGYQYDP YNLIFDSRRE QIARYVADRS GVLAFAHFPL IALFAGRNNF 300
  301 LEFISGVKYT SFIMFHKWLG RMMFLDAVIH GAAYTSYSVF YKDWAASKEE TYWQFGVAAL 360
  361 CIVGVMVFFS LAMFRKFFYE AFLFLHIVLG ALFFYTCWEH VVELSGIEWI YAAIAIWTID 420
  421 RLIRIVRVSY FGFPKASLQL VGDDIIRVTV KRPVRLWKAK PGQYVFVSFL HHLYFWQSHP 480
  481 FTVLDSIIKD GELTIILKEK KGVTKLVKKY VCCNGGKASM RLAIEGPYGS SSPVNNYDNV 540
  541 LLLTGGTGLP GPIAHAIKLG KTSAATGKQF IKLVIAVRGF NVLEAYKPEL MCLEDLNVQL 600
  601 HIYNTMEVPA LTPNDSLEIS QQDEKADGKG VVMATTLEQS PNPVEFDGTV FHHGRPNVEK 660
  661 LLHEVGDLNG SLAVVCCGPP VFVDEVRDQT ANLVLEKPAK AIEYFEEYQS W

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Qiu et al. (2008) FET3 FRE1 FRE3 FRE4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..188] PSI-BLAST 4.30103 Frequenin (neuronal calcium sensor 1)
    2 View Details [189..356] MSA 3.125987 View MSA. No confident structure predictions are available.
    3 View Details [357..529] PSI-BLAST 51.30103 cytochrome b5 reductase
    4 View Details [530..711] PSI-BLAST 51.30103 cytochrome b5 reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cation binding
    		•  2.62077305565026 bayes_pls_golite062009
  • metal ion binding
    		•  2.62077305565026 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.61874575467092 bayes_pls_golite062009
  • ion binding
    		•  2.61312132078717 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.57032504567157 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55650624542181 bayes_pls_golite062009
  • binding
    		•  2.54774920478325 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37465721152046 bayes_pls_golite062009
  • cation channel activity
    		•  1.49312394054212 bayes_pls_golite062009
  • calcium ion binding
    		•  1.40919295397643 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • protein binding
    		•  1.06263369232144 bayes_pls_golite062009
  • channel activity
    		•  1.05847414989139 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.05847414989139 bayes_pls_golite062009
  • ion channel activity
    		•  1.0369591011376 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.03529144716694 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.986621437232479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.910148857310729 bayes_pls_golite062009
  • potassium channel activity
    		•  0.906643355854798 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.896351900356978 bayes_pls_golite062009
  • gated channel activity
    		•  0.855502499003241 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.810245330492755 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.529057692398468 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.503769734882556 bayes_pls_golite062009
  • signal transducer activity
    		•  0.503769734882556 bayes_pls_golite062009
  • hydrolase activity
    		•  0.378268353045111 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.345084390599452 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • DNA binding
    		•  0.14285249145193 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0776924650284998 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • catalytic activity
    		•  1.45374095556065 bayes_pls_golite062009
  • transferase activity
    		•  1.15480450573972 bayes_pls_golite062009
  • binding
    		•  1.13408475648113 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.27336340260908 bayes_pls_golite062009
  • protein binding
    		•  0.144900113694048 bayes_pls_golite062009
  • cofactor binding
    		•  0.0731141170494622 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle