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Protein Overview: PDR10

General Information:
Name(s) found: PDR10 / YOR328W [SGD]
Description(s) found:
Found 27 descriptions.
SHOW ALL
  • ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1564 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISSLink to PubMed article]
    Biological Process: drug transmembrane transport [IEPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: ATPase activity, coupled to transmembrane movement of substances [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQAPSSSNS GLNQGNAAPD GPPNETQPYE GLDAAAQEEI KELARTLTSQ SSLLSQEKRI  60
   61 TGTGDPNTLT AASSSSLSRS IFASDIKGVN PILLDVNDPD YDETLDPRSE NFSSVRWVRN 120
  121 MAQICENDSD FYKPFSLGCA WKDLSASGDS ADITYQGTFG NMPIKYLKMS WRCISRRLFH 180
  181 RTHGKSEDND SGFQILKPMD GCINPGELLV VLGRPGAGCT TLLKSISVNT HGFKISPDTI 240
  241 ITYNGFSNKE IKNHYRGEVV YNAESDIHIP HLTVFQTLYT VARLKTPRNR IKGVDRDTFA 300
  301 KHMTEVAMAT YGLSHTADTK VGNDFVRGVS GGERKRVSIA EVSICGSKFQ CWDNATRGLD 360
  361 SATALEFIKA LKTQATITKS AATVAIYQCS KDAYDLFDKV CVLYDGYQIF FGPSKQAKKY 420
  421 FQRMGYVCPE RQTTADYLTS ITSPSERIKD KDMVKHGIMI PQTAYEMNQY WIQSEEYKQL 480
  481 QVQVNKHLDT DSSQQREQIK NAHIAKQSKR ARPSSPYTVS FFLQVKYILI RDIWRIKNDP 540
  541 SIQLFTVLSH AAMALILGSM FYEVMLSTTT TTFYYRGAAI FFAILFNAFS SLLEIFSLYE 600
  601 TRPITEKHKT YSLYRPSADA FASTFSDVPT KLATAVTFNI PYYFLINLKR DAGAFFFYFL 660
  661 INIITVFAMS HLFRCIGSVS KTLPQAMVPA SVLLLAFAMY TGFAIPRVQM LGWSKWISYI 720
  721 NPLSYLFESL MINEFHGRNF PCAQYIPSGP NYVNATGDEV TCSALGSIPG NNYVSGDDFI 780
  781 QTNYGYRHKN KWRSVGIGLA YIIFFLFLYL FFCEYNEGAK QNGEMLVFPH SVVKKMKKKG 840
  841 IVSEKKKKNQ PTLSTSDAEK DVEMNNNSSA TDSRFLRDSD AAIMGNDKTV AKEHYSSPSS 900
  901 SASQSNSFSK SDDIELSKSQ AIFHWKNLCY DIPIKNGKRR ILDNVDGWVK PGTLTALIGA 960
  961 SGAGKTTLLD CLAERTTMGL ITGDVFVDGR PRDQSFPRSI GYCQQQDLHL KTATVRESLR1020
 1021 FSAYLRQADD VSIEEKDKYV EEVIEVLEMK LYADAIVGVP GEGLNVEQRK RLTIGVELAA1080
 1081 KPKLLVFLDE PTSGLDSQTA WSTCQLMKKL ASRGQAILCT IHQPSALLMQ EFDRLLFLQE1140
 1141 GGQTVYFGEL GKGCKTMINY FEAHGAHKCP PDANPAEWML EIVGAAPGTH ASQDYFAIWR1200
 1201 DSEEYREMQK ELDWMERELP KRTEGSSNEE QKEFATSTLY QIKLVSYRLF HQYWRTPFYL1260
 1261 WSKFFSTIVS ELFIGFTFFK ANTSLQGLQN QMLAIFMFTV VFNPILQQYL PLFVQQRELY1320
 1321 EARERPSRTF SWKAFIVSQI LVEIPWNLLA GTIAFFVYYY PVGFYRNASY ANQLHERGAL1380
 1381 FWLFACAFYV YISSMGVLVI SCIEIAENAA NLASLFFIMS LSFCGVLATP NILPRFWIFM1440
 1441 YRVSPLTYLI DALLSVGLAN ASVVCSSNEL LKIVPPSGMT CSEYMEPYMQ STGTGYLLDG1500
 1501 SSETECHFCQ FSSTNDYLAT VSSSYSRRWM NYGIFSAYIV FDYCAAIFLY WLVRVPKKSK1560
 1561 KLKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) PDR10 RPS24A, RPS24B UTH1 YBL111C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] deduced N/A No confident structure predictions are available.
    2 View Details [112..201]
    [223..256]    		 PSI-BLAST 172.927757 Haemolysin B ATP-binding protein
    3 View Details [202..222]
    [257..450]    		 PSI-BLAST 172.927757 Haemolysin B ATP-binding protein
    4 View Details [451..711] MSA 6.628966 View MSA. No confident structure predictions are available.
    5 View Details [712..884] deduced N/A No confident structure predictions are available.
    6 View Details [885..1173] PSI-BLAST 127.491979 MJ0796
    7 View Details [1174..1475] MSA 21.541966 View MSA. No confident structure predictions are available.
    8 View Details [1476..1564] deduced N/A No confident structure predictions are available.
    9 View Details [1372..1564] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  6.58863529263644 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  6.58067278719409 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  6.57974651657836 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  6.57922174989907 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  6.57807080367604 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  6.48406410175216 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  6.48154954364331 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  6.40467109535527 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  6.40151534181487 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  6.38373914253885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  6.38247436082206 bayes_pls_golite062009
  • ATPase activity
    		•  6.30019941712404 bayes_pls_golite062009
  • hydrolase activity
    		•  4.60957912556603 bayes_pls_golite062009
  • sterol transporter activity
    		•  4.45355165759136 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.4837867129694 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  3.40690615950081 bayes_pls_golite062009
  • ribonucleotide binding
    		•  3.40594996232845 bayes_pls_golite062009
  • purine nucleotide binding
    		•  3.3669118613715 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • nucleotide binding
    		•  3.33248266870364 bayes_pls_golite062009
  • ATP binding
    		•  3.17398570826788 bayes_pls_golite062009
  • lipid transporter activity
    		•  3.14635082108971 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  3.12628113185041 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  3.0710107594224 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  3.05511942104215 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.88476360771975 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  2.72457626066894 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.69529191205818 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.61311581579476 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • eye pigment precursor transporter activity
    		•  2.19742277986318 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  2.15656963765495 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  2.12727614888121 bayes_pls_golite062009
  • binding
    		•  2.01755875920323 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  1.88153949603611 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.82177108193332 bayes_pls_golite062009
  • azole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • fluconazole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.58971273330352 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  1.37783759788533 bayes_pls_golite062009
  • cation channel activity
    		•  1.33585529285301 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.19353064661766 bayes_pls_golite062009
  • potassium channel activity
    		•  1.17288958041707 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.00384984515681 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.896078342024449 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.889208591820696 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.871525745291603 bayes_pls_golite062009
    		• 0.869999622006359 bayes_pls_golite062009
  • ion channel activity
    		•  0.848261056209476 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.806331380134838 bayes_pls_golite062009
  • channel activity
    		•  0.806331380134838 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.799997700906738 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • phospholipid transporter activity
    		•  0.755445322666929 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.70364355116614 bayes_pls_golite062009
  • gated channel activity
    		•  0.650050847753837 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  0.442220326523999 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.43332053110728 bayes_pls_golite062009
  • DNA binding
    		•  0.361518668029935 bayes_pls_golite062009
  • canalicular bile acid transmembrane transporter activity
    		•  0.301752323171649 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  0.227570438294493 bayes_pls_golite062009
  • GTPase activity
    		•  0.20164416416912 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.169034229773346 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • motor activity
    		•  0.14734538548583 bayes_pls_golite062009
  • signal transducer activity
    		•  0.144122328222529 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.144122328222529 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.133605084599819 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  6.58863529263644 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  6.58067278719409 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  6.57974651657836 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  6.57922174989907 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  6.57807080367604 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  6.48406410175216 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  6.48154954364331 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  6.40467109535527 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  6.40151534181487 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  6.38373914253885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  6.38247436082206 bayes_pls_golite062009
  • ATPase activity
    		•  6.30019941712404 bayes_pls_golite062009
  • hydrolase activity
    		•  4.60957912556603 bayes_pls_golite062009
  • sterol transporter activity
    		•  4.45355165759136 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.4837867129694 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  3.40690615950081 bayes_pls_golite062009
  • ribonucleotide binding
    		•  3.40594996232845 bayes_pls_golite062009
  • purine nucleotide binding
    		•  3.3669118613715 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • nucleotide binding
    		•  3.33248266870364 bayes_pls_golite062009
  • ATP binding
    		•  3.17398570826788 bayes_pls_golite062009
  • lipid transporter activity
    		•  3.14635082108971 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  3.12628113185041 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  3.0710107594224 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  3.05511942104215 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.88476360771975 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  2.72457626066894 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.69529191205818 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.61311581579476 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • eye pigment precursor transporter activity
    		•  2.19742277986318 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  2.15656963765495 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  2.12727614888121 bayes_pls_golite062009
  • binding
    		•  2.01755875920323 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  1.88153949603611 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.82177108193332 bayes_pls_golite062009
  • azole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • fluconazole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.58971273330352 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  1.37783759788533 bayes_pls_golite062009
  • cation channel activity
    		•  1.33585529285301 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.19353064661766 bayes_pls_golite062009
  • potassium channel activity
    		•  1.17288958041707 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.00384984515681 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.896078342024449 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.889208591820696 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.871525745291603 bayes_pls_golite062009
    		• 0.869999622006359 bayes_pls_golite062009
  • ion channel activity
    		•  0.848261056209476 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.806331380134838 bayes_pls_golite062009
  • channel activity
    		•  0.806331380134838 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.799997700906738 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • phospholipid transporter activity
    		•  0.755445322666929 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.70364355116614 bayes_pls_golite062009
  • gated channel activity
    		•  0.650050847753837 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  0.442220326523999 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.43332053110728 bayes_pls_golite062009
  • DNA binding
    		•  0.361518668029935 bayes_pls_golite062009
  • canalicular bile acid transmembrane transporter activity
    		•  0.301752323171649 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  0.227570438294493 bayes_pls_golite062009
  • GTPase activity
    		•  0.20164416416912 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.169034229773346 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • motor activity
    		•  0.14734538548583 bayes_pls_golite062009
  • signal transducer activity
    		•  0.144122328222529 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.144122328222529 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.133605084599819 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle