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Protein Overview: LSC1

General Information:
Name(s) found: LSC1 / YOR142W [SGD]
Description(s) found:
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  • gi|6324716|ref|NP_014785.1| Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated; Lsc1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S61696 succinate-CoA ligase (EC 6.2.1.-) alpha chain - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1711576|sp|P53598.1|SUCA_YEAST RecName: Full=Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial; AltName: Full=Succinyl-CoA synthetase subunit alpha; Short=SCS-alpha; Flags: Precursor [NCBI NR]
  • gi|1420358|emb|CAA99342.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1164984|emb|CAA64059.1| YOR3352w [Saccharomyces cerevisiae] [NCBI NR]
  • Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial OS=Saccharomyces cerevisiae GN=LSC1 PE=1 SV=1 [Swiss-Prot]
  • LSC1 Succinate-CoA ligase alpha subunit [mips]
  • Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated [SGD]
  • (P53598) Succinyl-CoA ligase [GDP-forming] alpha-chain, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase, alpha chain) (SCS-alpha) [4932.FASTACCERV.txt]
  • Chr XV from 593057-594046 [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 593056-594045 [yeastorf3.fasta]
  • LSC1, Chr XV from 593056-594045 [yeast_orfs2]
  • LSC1 SGDID:S0005668, Chr XV from 593057-594046, Verified ORF [yeastflysequest.fasta]
  • Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate [Saccharomyces cerevisiae]gi|1420358|emb|CAA99342.1| unnamed protein product [Saccharom [nrdb_11152004_Chlamydomonas]
  • LSC1 SGDID:S000005668, Chr XV from 593057-594046, Verified ORF, "Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • LSC1 SGDID:S000005668, Chr XV from 593058-594047, Verified ORF, "Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate" [yeast-contam.fasta]
  • LSC1 SGDID:S000005668, Chr XV from 593058-594047, Verified ORF, "Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; Lsc1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YOR3352w [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial precursor (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LSC1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • LSC1 SGDID:S000005668, Chr XV from 593057-594046, Genome Release 64-1-1, Verified ORF, "Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated" [yeast-030211-contam.fasta]
  • LSC1 SGDID:S000005668, Chr XV from 593057-594046, Genome Release 64-2-1, Verified ORF, "Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated" [20141208_orf_trans.fasta]
  • TR773|c0_g1_i1|g.522 ORF TR773|c0_g1_i1|g.522 TR773|c0_g1_i1|m.522 type:complete len:330 (+) TR773|c0_g1_i1:231-1220(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YOR142W SGDID:S000005668, Chr XV from 593057-594046, Genome Release 64-1-1, Verified ORF, "Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_2309|g.1653 ORF asmbl_2309|g.1653 asmbl_2309|m.1653 type:complete len:330 (+) asmbl_2309:229-1218(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_2313|g.1621 ORF ID=asmbl_2313|g.1621 ID=asmbl_2313|m.1621 type:complete len:330 (+) ID=asmbl_2313:229-1218(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LSC1 PE=1 SV=1 [Swanson-Carlisle-Scereplusabalone-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 329 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed article]
    Biological Process: tricarboxylic acid cycle [TASLink to PubMed article]
    succinyl-CoA metabolic process [IDALink to PubMed article][TASLink to PubMed article]
    Molecular Function: succinate-CoA ligase (ADP-forming) activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRSTVSKAS LKICRHFHRE SIPYDKTIKN LLLPKDTKVI FQGFTGKQGT FHASISQEYG  60
   61 TNVVGGTNPK KAGQTHLGQP VFASVKDAIK ETGATASAIF VPPPIAAAAI KESIEAEIPL 120
  121 AVCITEGIPQ HDMLYIAEML QTQDKTRLVG PNCPGIINPA TKVRIGIQPP KIFQAGKIGI 180
  181 ISRSGTLTYE AVQQTTKTDL GQSLVIGMGG DAFPGTDFID ALKLFLEDET TEGIIMLGEI 240
  241 GGKAEIEAAQ FLKEYNFSRS KPMPVASFIA GTVAGQMKGV RMGHSGAIVE GSGTDAESKK 300
  301 QALRDVGVAV VESPGYLGQA LLDQFAKFK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LSC1 LSC2
    View Details Krogan NJ, et al. (2006) LSC1 LSC2
    View Details Ho Y, et al. (2002) AAC3 ACC1 ACO1 ADR1 ATP3 CCL1 CCT3 COP1 CPA2 DEF1 FOL2 GAL7 HOR2 HXT6 IDH1 LSC1 LST8 LYS12 MET18 PHO86 POR1 RAD3 RHR2 RPN1 RPN12 RPT3 RRP3 SIP1 SLC1 STI1 TFP1 THI22 YBT1 YKU80 YML020W
    View Details Qiu et al. (2008) LSC1 LSC2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LSC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..160] PSI-BLAST 876.491979 Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain; Succinyl-CoA synthetase, alpha-chain, C-terminal domain
    2 View Details [161..329] PSI-BLAST 876.491979 Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain; Succinyl-CoA synthetase, alpha-chain, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • succinate-CoA ligase activity
    		•  11.5979130191209 bayes_pls_golite062009
  • succinate-CoA ligase (GDP-forming) activity
    		•  10.9659410855563 bayes_pls_golite062009
  • CoA-ligase activity
    		•  10.4192804448897 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  10.243481928473 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  9.48706872092269 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  9.35325976720833 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  4.38786524125089 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  3.07329302783164 bayes_pls_golite062009
  • ligase activity
    		•  2.30626698552338 bayes_pls_golite062009
  • catalytic activity
    		•  1.90735517755117 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  1.70038641098437 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • malic enzyme activity
    		•  1.2147813077436 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.15639517822408 bayes_pls_golite062009
  • L-malate dehydrogenase activity
    		•  1.02646414923682 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.99118526697655 bayes_pls_golite062009
  • ATP citrate synthase activity
    		•  0.917482134347073 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.576163737662951 bayes_pls_golite062009
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
    		•  0.120195861875768 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.0913823272876781 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.00644214957417527 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle