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Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
Acc: GO:0004473
Aspect: Molecular Function
Desc: Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
Synonyms:
  • (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
  • malate dehydrogenase (NADP, decarboxylating)
  • NADP-malic enzyme activity
  • L-malate:NADP oxidoreductase activity
  • NADP-specific malate dehydrogenase activity
  • malate dehydrogenase (decarboxylating, NADP)
  • NADP-linked decarboxylating malic enzyme
  • 'malic' enzyme
  • NADP-specific malic enzyme
Proteins in PDR annotated with:
   This term: 27 [Search]
   Term or descendants: 27 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004473 - malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity (interactive image map)
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Created and Maintained by: Michael Riffle