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Protein Overview: CDC73

General Information:
Name(s) found: CDC73 / YLR418C [SGD]
Description(s) found:
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  • gi|74644972|sp|Q06697.1|CDC73_YEAST RecName: Full=Cell division control protein 73; AltName: Full=RNA polymerase-associated protein CDC73 [NCBI NR]
  • gi|632679|gb|AAB67500.1| Cdc73p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323450|ref|NP_013522.1| Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere [NCBI NR]
  • pir||S59383 probable membrane protein YLR418c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Cell division control protein 73 OS=Saccharomyces cerevisiae GN=CDC73 PE=1 SV=1 [Swiss-Prot]
  • CDC73 DNA-directed RNA polymerase II accessory protein [mips]
  • Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance [SGD]
  • CDC73, Chr XII from 956909-958090, reverse complement [yeast_orfs2]
  • Chr XII from 956909-958090, reverse complement [yeastorf3.fasta]
  • Chr XII from 958090-956909, reverse complement [yeastorf5.fasta]
  • >Q06697 (Q06697) Chromosome XII COSMID 9931 [4932.FASTACCERV.txt]
  • CDC73 SGDID:S0004410, Chr XII from 958091-956910, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Cdc73p [Saccharomyces cerevisiae]gi|632679|gb|AAB67500.1| Cdc73p [Saccharomyces cerevisiae]gi|1363749|pir||S59383 probable membrane protein YLR418c - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • (Q06697) Cdc73p [cerv4932.FASTAC]
  • CDC73 SGDID:S000004410, Chr XII from 958091-956910, reverse complement, Verified ORF, "Substituent of the Paf1 complex together with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for t [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • CDC73 SGDID:S000004410, Chr XII from 958092-956911, reverse complement, Verified ORF, "Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of [yeast-contam.fasta]
  • Cell division control protein 73 (RNA polymerase-associated protein CDC73) [nr-271106-contam.fasta]
  • Cdc73p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance; Cdc73p [Sacchar [nr-271106-contam.fasta]
  • CDC73 SGDID:S000004410, Chr XII from 958092-956911, reverse complement, Verified ORF, "Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some hist [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • CDC73 SGDID:S000004410, Chr XII from 958092-956911, reverse complement, Verified ORF, "Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • CDC73 SGDID:S000004410, Chr XII from 958092-956911, reverse complement, Verified ORF, "Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance" [SGDyeast.20101221.fasta]
  • Cell division control protein 73 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC73 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • CDC73 SGDID:S000004410, Chr XII from 958095-956914, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay" [yeast-030211-contam.fasta]
  • CDC73 SGDID:S000004410, Chr XII from 958095-956914, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homologue, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers" [20141208_orf_trans.fasta]
  • TR5273|c0_g1_i1|g.3552 ORF TR5273|c0_g1_i1|g.3552 TR5273|c0_g1_i1|m.3552 type:complete len:394 (+) TR5273|c0_g1_i1:138-1319(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YLR418C SGDID:S000004410, Chr XII from 958095-956914, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_7016|g.5194 ORF asmbl_7016|g.5194 asmbl_7016|m.5194 type:complete len:394 (+) asmbl_7016:138-1319(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_7001|g.4372 ORF ID=asmbl_7001|g.4372 ID=asmbl_7001|m.4372 type:complete len:394 (+) ID=asmbl_7001:138-1319(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 393 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    transcription elongation factor complex [IPILink to PubMed article]
    Cdc73/Paf1 complex [IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: DNA recombination [IMPLink to PubMed article]
    histone methylation [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: RNA polymerase II transcription elongation factor activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANSLDRLRE HLKNGDKLVL KNNEGQSTDD ITKATMVETL SSDGSTQDSF PLNEETEIEI  60
   61 DGSLVQLRII VHCWMNKDSS AADYLADCQN KQLTNVSFLQ RTDLINWLSG NTESSQYLKA 120
  121 PGQKGETSDK VDIENKTLAG ELSTVKSTTS ASLENDSEVS DPVVVETMKH ERILVDHNSA 180
  181 LRGAKPINFG YLIKDAELKL VQSIKGSLRG SKLPPGHKGA HGRISKTNGS SGGPRKDPII 240
  241 LIPSAASSIL TVANIKQFLL ESKYVNPRNL PSVPNGLVNI EKNFERISRP IRFIIVDNTR 300
  301 MFTKPEYWDR VVAIFTTGHT WQFNNYQWNS PQELFQRCKG YYFHFAGDSV PQHVQQWNVE 360
  361 KVELDKNKRF KDVEVVRYFW HSLEKELISR GYR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC73 CKA1 CKA2 CKB1 CKB2 CTR9 LEO1 PAF1 POB3 RTF1 SPT16
    View Details (MIPS) Mewes HW, et al. (2004) CDC73 RPB10 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPC10 RPO21 RPO26
    View Details Krogan NJ, et al. (2006) ARA2 AYT1 BRO1 CDC73 CTR9 GLO4 HHT1, HHT2 LEO1 PAF1 PML39 POB3 PSH1 RTF1 SEN1 SPT16 YHR035W
    View Details Gavin AC, et al. (2002) CDC73 CKA1 CKA2 CKB1 CKB2 CTR9 IML1 LEO1 LYS12 PAF1 POB3 RTF1 SPT16
    View Details Qiu et al. (2008) CDC73 CHD1 CTR9 DST1 ELA1 ELC1 LEO1 PAF1 RPB10 RPB3 RPB9 RTF1 SPN1 SPT16 SPT4 SPT5 SPT6 TAF9 TFB5 TFG1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MET18 CDC73 1 Unpublished Fields Lab Data
    View Screen UBC7 CDC73 1 Unpublished Fields Lab Data
    View Screen HRT1 CDC73 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CDC73 Huh WK, et al. (2003)
    View Data CDC73 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..133] deduced N/A No confident structure predictions are available.
    2 View Details [134..393] MSA 5.010944 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle