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Protein Overview: IRC20

General Information:
Name(s) found: IRC20 / YLR247C [SGD]
Description(s) found:
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  • gi|74676414|sp|Q06554.1|YL247_YEAST RecName: Full=Uncharacterized ATP-dependent helicase YLR247C [NCBI NR]
  • gi|662344|gb|AAB67400.1| Ylr247cp [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323276|ref|NP_013348.1| Putative helicase; localized to mitochondria and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52 foci; Irc20p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S59393 probable membrane protein YLR247c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Uncharacterized ATP-dependent helicase YLR247C OS=Saccharomyces cerevisiae GN=YLR247C PE=1 SV=1 [Swiss-Prot]
  • Protein involved in DNA topology [mips]
  • Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci [SGD]
  • YLR247C, Chr XII from 628684-633354, reverse complement [yeast_orfs2]
  • Chr XII from 628684-633354, reverse complement [yeastorf3.fasta]
  • Chr XII from 633354-628684, reverse complement [yeastorf5.fasta]
  • >Q06554 (Q06554) Similar to S. CEREVISIAE RAD16 [4932.FASTACCERV.txt]
  • YLR247C SGDID:S0004237, Chr XII from 633356-628686, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • Ylr247cp [Saccharomyces cerevisiae]gi|1363737|pir||S59393 probable membrane protein YLR247c - yeast (Saccharomyces cerevisiae)gi|662344|gb|AAB67400.1| Ylr247cp [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • (Q06554) Ylr247cp [cerv4932.FASTAC]
  • YLR247C SGDID:S000004237, Chr XII from 633356-628686, reverse complement, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YLR247C SGDID:S000004237, Chr XII from 633356-628686, reverse complement, Uncharacterized ORF, "Putative helicase; localized to mitochondria and the nucleus; YLR247C is not an essential gene" [yeast-contam.fasta]
  • IRC20 SGDID:S000004237, Chr XII from 633356-628686, reverse complement, Verified ORF, "Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Putative helicase; localized to mitochondria and the nucleus; YLR247C is not an essential gene; Ylr247cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ylr247cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • IRC20 SGDID:S000004237, Chr XII from 633354-628684, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci" [yeast-030211-contam.fasta]
  • IRC20 SGDID:S000004237, Chr XII from 633354-628684, Genome Release 64-2-1, reverse complement, Verified ORF, "E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent nonhomologous end joining (NHEJ) pathway; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; interacts with Cdc48p and Smt3p; null mutant displays increased levels of spontaneous Rad52p foci" [20141208_orf_trans.fasta]
  • YLR247C SGDID:S000004237, Chr XII from 633354-628684, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1556 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAVGALLAR EYNVTAEKCD FFLENGSFDS VIAALPALNQ EQETVTQKVS KNGKELINVA  60
   61 SVNIEIPERI SLSNNGRQLF KFIVDIEILP CENDNEATLV VSSDSVSLFQ IGFKMENNSK 120
  121 IAVDKQLPLI LDICAHKNQE RALRNQLENR KSLERKPSRK RRKKNSNVND PEKLLKSRIH 180
  181 ELSLSYKDFE CSPVVFRYND SSLTWVLSFN LKLKFLNNKF NRFSVEANQI LDLTFSNRDE 240
  241 NEFERYHKHS HIHSNFIQKQ FISQILEYSK DRLSKIKPFL PQSIPDLKVN LLPFQRESVE 300
  301 WMLIKEGHGN SLSDTPTVID EVGLIDFMNE YYAYGYELIA RSPDEVGPSL LWNKLTGYIL 360
  361 TTEDAAHLYN QYRKERLSGD YPVCAKGVLA EEMGLGKTIE ILSLILLNRR KLKDSEATFI 420
  421 DDENRTITKT KTTLIICPNA ILKQWLEEIE LHANSLKWYT YRGYNEIMKD CKTVDEAVQQ 480
  481 LCQYDIIVTS YNIIATEVHH AEFNRSIRSR RLKSPKYDYS SPLALMQFYR IILDEVQMLR 540
  541 SSSTYSAKCT SLLHRIHTWG VSGTPIQNIY NFRMIMSYLK LHPFCDEVDF IRTLQEEIKL 600
  601 RNEAKDYTSN DFVCQLKGVR FSIKDCMNIF YRYDLCIRHS KANVASQIHI PRQHNFIIPL 660
  661 EFAPIEWDNY LNLWNNFLEL SGYNSDGSGS PRVSNAFLNE WLSRLRYICC HALFPEILST 720
  721 RQKRLHGHLS RISNIDDILI SMRMDAFDSL IGYYRERFHL SIKQAQYELE ISNTPAKALE 780
  781 SFIKIRDDLM IHIRQKFNVE DPFDKSLNLS EDEDEHMDER FGEKETSSGD ESDREINGAK 840
  841 NHDNHNNDGM LSNHLKKKGL RAMMNLLHDC YFFLGSVYYN LGTRKLEEAD DKHRKEKTEE 900
  901 VVYSDVFPKN ELEEIEENRL LEQENYANAE ILRKSILSSE ARKVDMTIKM ARTKFAPMTS 960
  961 NIPLRLINIE FDHKNDYSSN LAVSRCFKSL SKLIEGLNEQ TKNFNELLDE LLIIIYEPVH1020
 1021 RTEDDDSTNK IIGNEEYSTS IDSQDKIFSL LGCLEIILQN RDNILTSESE VKIPKHLVPE1080
 1081 GSIISKYQKQ LLNSLRLISG TPLRTVFDEL KNSRIVRRIS SSNESESTIQ NFEDYLLQYE1140
 1141 VESKSLFKYN KQVRESLKIL GSIYNAKTEY YSQLQRISDS LVSLHSLSAP QLSHLIRTIN1200
 1201 KSLGGTLDAK INNIESRLIY LKNLSRLKDT LNDNQILSCS ICLGEVEIGA IIKCGHYFCK1260
 1261 SCILTWLRAH SKCPICKGFC SISEVYNFKF KNSTEKREKE IQEPRREGAD SSQDNSNENS1320
 1321 IISNMSEVEK LFGNKYEQFH QINEVHQIHI KESFGAKIDF VIKLISYLRL KSEQENADPP1380
 1381 QVILYSQKTE YLKVIGKVLK LYHIEHLACL SNTANVGETI NNFKRQPSVT CLLLNVKTLG1440
 1441 AGLNLINAKH IFLLDPILNN SDELQAMGRN NRIGQDEETF VWNFMIRNTV EENILRYKCI1500
 1501 LEERKRKEKS KKGDKYDEAQ DETDNEESDD AKFEISVVDQ EVSNEHLWNC FFHGSD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARC1 ATG14 CAT8 CCC2 HEK2 IRC20 MCA1 MES1 MGA2 NCS2 NHA1 PET127 PHO89 PHO91 YKL050C YLR363W-A
    View Details Ho Y, et al. (2002) CIN5 EXO70 HHF1, HHF2 HTA1 IRC20

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run IPI3 No Comments Hazbun TR, et al. (2003)
    View Run NSE3 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data IRC20 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..282] MSA 1.193996 View MSA. No confident structure predictions are available.
    2 View Details [283..718] Pfam 8.638272 SNF2 family N-terminal domain No confident structure predictions are available.
    3 View Details [719..878] MSA 2.253996 View MSA. No confident structure predictions are available.
    4 View Details [879..1236] deduced N/A No confident structure predictions are available.
    5 View Details [1237..1276] Pfam 7.568636 Zinc finger, C3HC4 type (RING finger) No confident structure predictions are available.
    6 View Details [1277..1476] PSI-BLAST 4.522879 Putative DEAD box RNA helicase
    7 View Details [1477..1556] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.68908265056856 bayes_pls_golite062009
  • chromatin binding
    		•  0.901919966053279 bayes_pls_golite062009
  • protein binding
    		•  0.40894004702539 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.280209685341429 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0640203857327035 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  1.26687146372087 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.420384345567397 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.411077559082206 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.399864241228259 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.398496265411009 bayes_pls_golite062009
  • catalytic activity
    		•  0.234613562021476 bayes_pls_golite062009
  • hydrolase activity
    		•  0.216831145240405 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  1.33062723118115 bayes_pls_golite062009
  • protein binding
    		•  0.278046871496516 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle