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Protein Overview: STE3

General Information:
Name(s) found: STE3 / YKL178C [SGD]
Description(s) found:
Found 36 descriptions.
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  • Receptor for a factor pheromone, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPC [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 470 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: mating-type a-factor pheromone receptor activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKSAIIGL CLLAVILLAP PLAWHSHTKN IPAIILITWL LTMNLTCIVD AAIWSDDDFL  60
   61 TRWDGKGWCD IVIKLQVGAN IGISCAVTNI IYNLHTILKA DSVLPDLSSW TKIVKDLVIS 120
  121 LFTPVMVMGF SYLLQVFRYG IARYNGCQNL LSPTWITTVL YTMWMLIWSF VGAVYATLVL 180
  181 FVFYKKRKDV RDILHCTNSG LNLTRFARLL IFCFIIILVM FPFSVYTFVQ DLQQVEGHYT 240
  241 FKNTHSSTIW NTIIKFDPGR PIYNIWLYVL MSYLVFLIFG LGSDALHMYS KFLRSIKLGF 300
  301 VLDMWKRFID KNKEKRVGIL LNKLSSRKES RNPFSTDSEN YISTCTENYS PCVGTPISQA 360
  361 HFYVDYRIPD DPRKSQNKSK KYLFADKETD DILDEIDLKE SRHIPYVTQG QSFDDEISLG 420
  421 GFSKVTLDYS EKLHNSASSN FEGESLCYSP ASKEENSSSN EHSSENTAGP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MSB2 STE2 STE3 STE4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen STE3 DCC1 1 Unpublished Fields Lab Data
    View Screen STE3 AIR1 1 Unpublished Fields Lab Data
    View Screen STE3 TUP1 1 Unpublished Fields Lab Data
    View Screen STE3 IMP2' 1 Unpublished Fields Lab Data
    View Screen STE3 NRG1 1 Unpublished Fields Lab Data
    View Screen STE3 GON7 1 Unpublished Fields Lab Data
    View Screen STE3 PAA1 1 Unpublished Fields Lab Data
    View Screen STE3 COX12 1 Unpublished Fields Lab Data
    View Screen STE3 ATC1 1 Unpublished Fields Lab Data
    View Screen STE3 APT1 1 Unpublished Fields Lab Data
    View Screen STE3 TFB3 1 Unpublished Fields Lab Data
    View Screen STE3 MIH1 1 Unpublished Fields Lab Data
    View Screen STE3 YER187W 1 Unpublished Fields Lab Data
    View Screen STE3 YNL089C 1 Unpublished Fields Lab Data
    View Screen STE3 RPB9 1 Unpublished Fields Lab Data
    View Screen STE3 RTG1 1 Unpublished Fields Lab Data
    View Screen STE3 CUP2 1 Unpublished Fields Lab Data
    View Screen STE3 CKB2 1 Unpublished Fields Lab Data
    View Screen STE3 NIF3 1 Unpublished Fields Lab Data
    View Screen STE3 ESA1 1 Unpublished Fields Lab Data
    View Screen STE3 MUQ1 1 Unpublished Fields Lab Data
    View Screen STE3 RIM20 1 Unpublished Fields Lab Data
    View Screen ELM1 STE3 1 Unpublished Fields Lab Data
    View Screen STE3 TPO2 1 Unpublished Fields Lab Data
    View Screen STE3 YPR076W 1 Unpublished Fields Lab Data
    View Screen STE3 YPR137C-A, YAR010C 1 Unpublished Fields Lab Data
    View Screen STE3 UBA4 1 Unpublished Fields Lab Data
    View Screen STE3 SUA7 1 Unpublished Fields Lab Data
    View Screen STE3 PDR3 1 Unpublished Fields Lab Data
    View Screen STE3 PEX18 1 Unpublished Fields Lab Data
    View Screen STE3 YPR089W 1 Unpublished Fields Lab Data
    View Screen STE3 UMP1 1 Unpublished Fields Lab Data
    View Screen STE3 IKI1 1 Unpublished Fields Lab Data
    View Screen BUR2 STE3 1 Unpublished Fields Lab Data
    View Screen STE3 BUD3 1 Unpublished Fields Lab Data
    View Screen STE3 AIM18 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..332] Pfam 163.677781 Pheromone A receptor No confident structure predictions are available.
    2 View Details [333..470] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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