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Protein Overview: UBA4

General Information:
Name(s) found: UBA4 / YHR111W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 440 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: response to oxidative stress [IMPLink to PubMed article]
    protein modification process [IDALink to PubMed article][IMPLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    cell budding [IGILink to PubMed article]
    invasive growth in response to glucose limitation [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: URM1 activating enzyme activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDYHLEDTT SELEALRLEN AQLREQLAKR EDSSRDYPLS LEEYQRYGRQ MIVEETGGVA  60
   61 GQVKLKNTKV LVVGAGGLGC PALPYLAGAG VGQIGIVDND VVETSNLHRQ VLHDSSRVGM 120
  121 LKCESARQYI TKLNPHINVV TYPVRLNSSN AFDIFKGYNY ILDCTDSPLT RYLVSDVAVN 180
  181 LGITVVSASG LGTEGQLTIL NFNNIGPCYR CFYPTPPPPN AVTSCQEGGV IGPCIGLVGT 240
  241 MMAVETLKLI LGIYTNENFS PFLMLYSGFP QQSLRTFKMR GRQEKCLCCG KNRTITKEAI 300
  301 EKGEINYELF CGARNYNVCE PDERISVDAF QRIYKDDEFL AKHIFLDVRP SHHYEISHFP 360
  361 EAVNIPIKNL RDMNGDLKKL QEKLPSVEKD SNIVILCRYG NDSQLATRLL KDKFGFSNVR 420
  421 DVRGGYFKYI DDIDQTIPKY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GUS1 QRI1 SLX4 UBA4 YOR097C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SNX41 UBA4 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data UBA4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..290] PSI-BLAST 443.9691 Molybdenum cofactor biosynthesis protein MoeB
    2 View Details [291..440] PSI-BLAST 17.154902 Sulfurtransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • URM1 activating enzyme activity
    		•  5.44388923879076 bayes_pls_golite062009
  • small protein activating enzyme activity
    		•  3.58068602287881 bayes_pls_golite062009
  • NEDD8 activating enzyme activity
    		•  2.11391077579348 bayes_pls_golite062009
  • thiosulfate sulfurtransferase activity
    		•  2.05168889065215 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.84216910649062 bayes_pls_golite062009
  • binding
    		•  1.46180162036652 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.31244773198273 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.27535252106053 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.23669539775752 bayes_pls_golite062009
  • catalytic activity
    		•  1.22201444897049 bayes_pls_golite062009
  • ligase activity
    		•  0.886082936938522 bayes_pls_golite062009
  • transferase activity
    		•  0.680338489823338 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.302798969355962 bayes_pls_golite062009
  • protein binding
    		•  0.258795594127926 bayes_pls_golite062009
    2
    Term Confidence Notes
  • thiosulfate sulfurtransferase activity
    		•  4.07143118207301 bayes_pls_golite062009
  • binding
    		•  1.53109235820839 bayes_pls_golite062009
  • transferase activity
    		•  1.00600613068372 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  0.765055251775806 bayes_pls_golite062009
  • catalytic activity
    		•  0.687308230067573 bayes_pls_golite062009
  • phosphatase activity
    		•  0.596156043915887 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.419061082217665 bayes_pls_golite062009
  • protein binding
    		•  0.415782692658192 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.41208200336081 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  0.224132693583958 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle