YRC Public Data Repository - Protein Structure Prediction

Protein:	UBA4
Organism:	Saccharomyces cerevisiae
Length:	440 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBA4.

Description	E-value	Query Range	Subject Range
UBA4_YEAST - Adenylyltransferase and sulfurtransferase UBA4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28... UBA4 - Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thio... UBA4_YEAS6 - Adenylyltransferase and sulfurtransferase UBA4 OS=Saccharomyces cerevisiae (strain AWRI1631) GN=UBA4... UBA4_YEAS1 - Adenylyltransferase and sulfurtransferase UBA4 OS=Saccharomyces cerevisiae (strain RM11-1a) GN=UBA4 ...	0.0	[1..440]	[1..440]
gi\|9714466, gi\|2... - gi\|9714466\|emb\|CAC01308.1\| putative sulfurylase [Streptomyces coelicolor A3(2)], gi\|21223547\|ref\|NP_...	2.0E-91	[28..440]	[2..392]
gi\|3025796 - gi\|3025796\|gb\|AAC24520.1\| molybdenum cofactor biosynthetic protein [Emericella nidulans] gi\|67523743, gi\|... - gi\|67523743\|ref\|XP_659931.1\| hypothetical protein AN2327.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	1.0E-90	[9..440]	[101..560]
CG13090-PA, FBpp... - This gene is referred to in FlyBase by the symbol Dmel\CG13090 (CG13090, FBgn0032054). It is a prote...	2.0E-90	[7..440]	[9..453]
MOCS3_ARATH - Adenylyltransferase and sulfurtransferase MOCS3 OS=Arabidopsis thaliana GN=MOCS3 PE=2 SV=1	2.0E-89	[6..440]	[25..464]
gi\|15827360 - gi\|15827360\|ref\|NP_301623.1\| molybdopterin biosynthesis-like protein MoeZ [Mycobacterium leprae TN] gi\|13092909, gi\|... - pir\|\|C87011 probably involved in molybdopterin biosynthesis [imported] - Mycobacterium leprae, gi\|13... gi\|221229838, gi... - gi\|221229838\|ref\|YP_002503254.1\| probably involved in molybdopterin biosynthesis [Mycobacterium lepr...	5.0E-88	[24..440]	[3..395]
gi\|9948117, gi\|1... - gi\|9948117\|gb\|AAG05491.1\|AE004638_1 probable molybdopterin biosynthesis protein MoeB [Pseudomonas ae... gi\|254240530, gi... - gi\|254240530\|ref\|ZP_04933852.1\| hypothetical protein PA2G_01186 [Pseudomonas aeruginosa 2192], gi\|19... gi\|11351520 - pir\|\|F83381 probable molybdopterin biosynthesis protein MoeB PA2103 [imported] - Pseudomonas aerugin...	9.0E-88	[36..440]	[10..392]
gi\|17230398, gi\|... - gi\|17230398\|ref\|NP_486946.1\| hypothetical protein all2906 [Nostoc sp. PCC 7120], gi\|17132000\|dbj\|BAB... gi\|25313623 - pir\|\|AC2169 molybdopterin biosynthesis protein [imported] - Nostoc sp. (strain PCC 7120)	2.0E-86	[30..440]	[2..390]
gi\|4337044 - gi\|4337044\|gb\|AAD18052.1\| molybdopterin synthase sulphurylase [Nicotiana plumbaginifolia]	3.0E-86	[39..440]	[3..401]

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Predicted Domain #1

Region A:
Residues: [1-290]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDYHLEDTT SELEALRLEN AQLREQLAKR EDSSRDYPLS LEEYQRYGRQ MIVEETGGVA  60
   61 GQVKLKNTKV LVVGAGGLGC PALPYLAGAG VGQIGIVDND VVETSNLHRQ VLHDSSRVGM 120
  121 LKCESARQYI TKLNPHINVV TYPVRLNSSN AFDIFKGYNY ILDCTDSPLT RYLVSDVAVN 180
  181 LGITVVSASG LGTEGQLTIL NFNNIGPCYR CFYPTPPPPN AVTSCQEGGV IGPCIGLVGT 240
  241 MMAVETLKLI LGIYTNENFS PFLMLYSGFP QQSLRTFKMR GRQEKCLCCG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	443.9691
Match:	1jw9B_
Description:	Molybdenum cofactor biosynthesis protein MoeB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
URM1 activating enzyme activity	5.44388923879076	bayes_pls_golite062009
small protein activating enzyme activity	3.58068602287881	bayes_pls_golite062009
NEDD8 activating enzyme activity	2.11391077579348	bayes_pls_golite062009
thiosulfate sulfurtransferase activity	2.05168889065215	bayes_pls_golite062009
small conjugating protein ligase activity	1.84216910649062	bayes_pls_golite062009
binding	1.46180162036652	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.31244773198273	bayes_pls_golite062009
acid-amino acid ligase activity	1.27535252106053	bayes_pls_golite062009
transcription regulator activity	1.23669539775752	bayes_pls_golite062009
catalytic activity	1.22201444897049	bayes_pls_golite062009
ligase activity	0.886082936938522	bayes_pls_golite062009
transferase activity	0.680338489823338	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.302798969355962	bayes_pls_golite062009
protein binding	0.258795594127926	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [291-440]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNRTITKEAI EKGEINYELF CGARNYNVCE PDERISVDAF QRIYKDDEFL AKHIFLDVRP  60
   61 SHHYEISHFP EAVNIPIKNL RDMNGDLKKL QEKLPSVEKD SNIVILCRYG NDSQLATRLL 120
  121 KDKFGFSNVR DVRGGYFKYI DDIDQTIPKY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.154902
Match:	1h4kX_
Description:	Sulfurtransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thiosulfate sulfurtransferase activity	4.07143118207301	bayes_pls_golite062009
binding	1.53109235820839	bayes_pls_golite062009
transferase activity	1.00600613068372	bayes_pls_golite062009
phosphoprotein phosphatase activity	0.765055251775806	bayes_pls_golite062009
catalytic activity	0.687308230067573	bayes_pls_golite062009
phosphatase activity	0.596156043915887	bayes_pls_golite062009
sulfurtransferase activity	0.419061082217665	bayes_pls_golite062009
protein binding	0.415782692658192	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.41208200336081	bayes_pls_golite062009
protein tyrosine phosphatase activity	0.224132693583958	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: