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Protein Overview: SLX4

General Information:
Name(s) found: SLX4 / YLR135W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Endonuclease involved in processing DNA during recombination and repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 748 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article][IMPLink to PubMed article]
    Biological Process: DNA replication [IMPLink to PubMed article]
    DNA-dependent DNA replication [IGILink to PubMed article]
    response to DNA damage stimulus [IGILink to PubMed article]
    Molecular Function: 5'-flap endonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELQRAQRNL KFLQNEDYVN VTDQTNLNGE SQNAYSLGME TQVPEMQFSL SSDDDSIGTQ  60
   61 VKSVTAQKSP MTQETTKNDT ERNKDVDKSC NPVSTSHPDL GGSNIEENIF INTQIQSRLD 120
  121 DAEEETNLKL KLEKFKYSFK SSNADDTHSN ANVTAKRRPA IRKANSKLKT KPKTKRDPKI 180
  181 IKNITDFNIN NYERSRTASL LKQLSGKHKK VLDIIKTQNE GNSDKPPRAR NNKGEKATFD 240
  241 TYSEQEWKDI MKLLLQKFPQ SEETDLNEVQ KFLYGSEKSS NSLDNQESSQ QRLWTASQLP 300
  301 PELPDEAIQP EQEERIRDTQ SAVNFLSLSQ VMDDKSEIMK DEESIIISRG DSTSSQEYGN 360
  361 GLEPQQPVGN VVGEDIELAV GTRINAFSLT DYKACKPMSV EVSRRCENST DNDYDNISIV 420
  421 SDTTDETSTL FPLDQYRYVF IENDERPPLA TDTIGSTQFF TPNTSPLDGI IDLTQESFKA 480
  481 VRSLISPLKV ENNKTGVTSQ ASNQVQVPAT RTPTIIPQKN LTTTLKTEEE KNNIGSSIRV 540
  541 KLLQESVVKL NPKLVKHNFY RVEANDSEEE ETEFDDQFCI ADIQLVDSSK ISTKDSTQNP 600
  601 TTSNDIIDTS AASSIASPEK FCEIMMSQSM KELRQSLKTV GLKPMRTKVE IIQSLQTASQ 660
  661 ILSTANPDNK GEHGGVANFS KIEIFDHLTE LIEAFPDFLE RIYTFEPIPL NELIEKLFSA 720
  721 EPFVSQIDEM TIREWADVQG ICLRNDKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GUS1 QRI1 SLX4 UBA4 YOR097C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SLX4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..748] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle