YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: APE2

General Information:
Name(s) found: APE2 / YKL157W [SGD]
Description(s) found:
SHOW ONLY BEST
  • gi|9755335|ref|NP_012765.2| Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/Y [NCBI NR]
  • gi|115502354|sp|P32454.3|APE2_YEAST RecName: Full=Aminopeptidase 2, mitochondrial; Short=Aminopeptidase II; Short=AP-II; AltName: Full=YscII; Flags: Precursor [NCBI NR]
  • Aminopeptidase 2, mitochondrial OS=Saccharomyces cerevisiae GN=APE2 PE=1 SV=3 [Swiss-Prot]
  • APE2 Aminopeptidase yscII [mips]
  • Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W [SGD]
  • APE2, Chr XI from 154993-155273,155657-158183 [yeast_orfs2]
  • Chr XI from 154993-155273,155657-158183 [yeastorf3.fasta]
  • Chr XI from 154992-155272,155656-158182 [yeastorf4.fasta]
  • APE2 SGDID:S0001640, Chr XI from 154996-155276,155660-158186, Verified ORF [yeastflysequest.fasta]
  • Ape2p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • APE2 SGDID:S000001640, Chr XI from 154996-155276,155660-158186, Verified ORF, "Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the a [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • APE2 SGDID:S000001640, Chr XI from 154996-155276,155660-158186, Verified ORF, "Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL15 [yeast-200209-contam.fasta]
  • Aminopeptidase 2, mitochondrial precursor (Aminopeptidase II) (AP-II) (YscII) [nr-271106-contam.fasta]
  • Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W; Ape2p [Saccharomyces [nr-271106-contam.fasta]
  • APE2 SGDID:S000001640, Chr XI from 154996-155276,155660-158186, Verified ORF, "Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W" [yeast-bovrabprots.fasta]
  • APE2 SGDID:S000001640, Chr XI from 154996-155276,155660-158186, Verified ORF, "Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 935 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NASLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cell wall-bounded periplasmic space [NASLink to PubMed article]
    Biological Process: peptide metabolic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: leucyl aminopeptidase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIVRWLLLK SAVRGSSLIG KAHPCLRSIA AHPRYLSNVY SPPAGVSRSL RINVMWKQSK  60
   61 LTPPRFVKIM NRRPLFTETS HACAKCQKTS QLLNKTPNRE ILPDNVVPLH YDLTVEPDFK 120
  121 TFKFEGSVKI ELKINNPAID TVTLNTVDTD IHSAKIGDVT SSEIISEEEQ QVTTFAFPKG 180
  181 TMSSFKGNAF LDIKFTGILN DNMAGFYRAK YEDKLTGETK YMATTQMEPT DARRAFPCFD 240
  241 EPNLKASFAI TLVSDPSLTH LSNMDVKNEY VKDGKKVTLF NTTPKMSTYL VAFIVAELKY 300
  301 VESKNFRIPV RVYATPGNEK HGQFAADLTA KTLAFFEKTF GIQYPLPKMD NVAVHEFSAG 360
  361 AMENWGLVTY RVVDLLLDKD NSTLDRIQRV AEVVQHELAH QWFGNLVTMD WWEGLWLNEG 420
  421 FATWMSWYSC NEFQPEWKVW EQYVTDTLQH ALSLDSLRSS HPIEVPVKKA DEINQIFDAI 480
  481 SYSKGASLLR MISKWLGEET FIKGVSQYLN KFKYGNAKTE DLWDALADAS GKDVRSVMNI 540
  541 WTKKVGFPVI SVSEDGNGKI TFRQNRYLST ADVKPDEDKT IYPVFLALKT KNGVDSSVVL 600
  601 SERSKTIELE DPTFFKVNSE QSGIYITSYT DERWAKLGQQ ADLLSVEDRV GLVADVKTLS 660
  661 ASGYTSTTNF LNLVSKWNNE KSFVVWDQII NSISSMKSTW LFEPKETQDA LDNFTKQLIS 720
  721 GMTHHLGWEF KSSDSFSTQR LKVTMFGAAC AARDADVEKA ALKMFTDYCS GNKEAIPALI 780
  781 KPIVFNTVAR VGGAENYEKV YKIYLDPISN DEKLAALRSL GRFKEPKLLE RTLGYLFDGT 840
  841 VLNQDIYIPM QGMRAHQEGV EALWNWVKKN WDELVKRLPP GLSMLGSVVT LGTSGFTSMQ 900
  901 KIDEIKKFFA TKSTKGFDQS LAQSLDTITS KAQWG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) APE2 YDL241W
    View Details Ho Y, et al. (2002) ACS2 ADE3 ADE6 ADO1 ALA1 APE2 ARA1 BAT1 CDC10 CLU1 CYS3 DED81 DPS1 ERG10 ERG20 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KRS1 LSP1 MDH3 OLA1 PAB1 PFK2 PGM2 PMI40 PRP6 SAC6 SCP160 SOD1 SSZ1 THR4 TRR1 UBA1 YDL124W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data APE2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] MSA 1.303987 View MSA. No confident structure predictions are available.
    2 View Details [90..590] PSI-BLAST 84.69897 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    3 View Details [591..808] MSA 1.228966 View MSA. No confident structure predictions are available.
    4 View Details [809..935] MSA 3.22199 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle