Protein Overview: CDC6

General Information:
Name(s) found:	CDC6 / YJL194W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|729078\|sp\|P09119.3\|CDC6_YEAST RecName: Full=Cell division control protein 6 [NCBI NR] gi\|6322266\|ref\|NP_012341.1\| Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. [NCBI NR] gi\|547601\|emb\|CAA54766.1\| cell division cycle protein [Saccharomyces cerevisiae] [NCBI NR] gi\|3510\|emb\|CAA46392.1\| CDC6 [Saccharomyces cerevisiae] [NCBI NR] gi\|171197\|gb\|AAA34483.1\| cell division cycle protein [NCBI NR] pir\|\|RGBYC6 cell division control protein CDC6 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1008409\|emb\|CAA89490.1\| CDC6 [Saccharomyces cerevisiae] [NCBI NR] Cell division control protein 6 OS=Saccharomyces cerevisiae GN=CDC6 PE=1 SV=3 [Swiss-Prot] CDC6 Cell division control protein [mips] Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p [SGD] CDC6, Chr X from 69337-70878 [yeast_orfs2] Chr X from 69337-70878 [yeastorf3.fasta] (P09119) Cell division control protein 6 [4932.FASTACCERV.txt] CDC6 SGDID:S0003730, Chr X from 69337-70878, Verified ORF [yeastflysequest.fasta] Cdc6p [Saccharomyces cerevisiae]gi\|1008409\|emb\|CAA89490.1\| CDC6 [Saccharomyces cerevisiae]gi\|547601\|emb\|CAA54766.1\| cell division cycle protein [Saccharomyces cerevisiae]gi\|3510\|emb\|CAA46392.1\| CDC6 [Saccharomyces cerevisiae]gi\|1070533\|pir\|\|RGBYC6 cel [nrdb_11152004_Chlamydomonas] CDC6 SGDID:S000003730, Chr X from 69337-70878, Verified ORF, "Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; Cdc6p [Sacchar [nr-271106-contam.fasta] Cell division control protein 6 [nr-271106-contam.fasta] cell division cycle protein [nr-271106-contam.fasta] CDC6 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] cell division cycle protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CDC6 SGDID:S000003730, Chr X from 69337-70878, Verified ORF, "Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Cell division control protein 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC6 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CDC6 SGDID:S000003730, Chr X from 69338-70879, Genome Release 64-1-1, Verified ORF, "Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p" [yeast-030211-contam.fasta] CDC6 SGDID:S000003730, Chr X from 69338-70879, Genome Release 64-2-1, Verified ORF, "Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress" [20141208_orf_trans.fasta] YJL194W SGDID:S000003730, Chr X from 69338-70879, Genome Release 64-1-1, Verified ORF, "Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	513 amino acids
Gene Ontology:
Cellular Component:	pre-replicative complex [TAS]
Biological Process:	pre-replicative complex assembly [TAS]
Molecular Function:	ATPase activity [TAS] DNA clamp loader activity [TAS] protein binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAIPITPTK RIRRNLFDDA PATPPRPLKR KKLQFTDVTP ESSPEKLQFG SQSIFLRTKA  60
   61 LLQKSSELVN LNSSDGALPA RTAEYEQVMN FLAKAISEHR SDSLYITGPP GTGKTAQLDM 120
  121 IIRQKFQSLP LSLSTPRSKD VLRHTNPNLQ NLSWFELPDG RLESVAVTSI NCISLGEPSS 180
  181 IFQKIFDSFQ DLNGPTLQIK NMQHLQKFLE PYHKKTTFVV VLDEMDRLLH ANTSETQSVR 240
  241 TILELFLLAK LPTVSFVLIG MANSLDMKDR FLSRLNLDRG LLPQTIVFQP YTAEQMYEIV 300
  301 IQKMSSLPTI IFQPMAIKFA AKKCAGNTGD LRKLFDVLRG SIEIYELEKR FLLSPTRGSL 360
  361 NSAQVPLTPT TSPVKKSYPE PQGKIGLNYI AKVFSKFVNN NSTRTRIAKL NIQQKLILCT 420
  421 IIQSLKLNSD ATIDESFDHY IKAITKTDTL APLQRNEFLE ICTILETCGL VSIKKTKCKG 480
  481 KTKRFVDKID VDLDMREFYD EMTKISILKP FLH

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		CDC45 CDC6 DPB11 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SLD3
View Details	Krogan NJ, et al. (2006)		CDC6 HSF1 YLR419W
View Details	Gavin AC, et al. (2006)		CDC6 GET3
View Details	Gavin AC, et al. (2002)		BLM10 CAB5 CDC6 ECM29 GFA1 MLH2 NAS6 PGK1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP3 RGR1 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SCL1 UBP6 YFL006W
View Details	Qiu et al. (2008)		CDC6 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	CDC6	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..290]	PSI-BLAST	52.39794	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
2	View Details	[291..358]	PSI-BLAST	52.39794	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
3	View Details	[359..513]	ORFEUS	11.61	CDC6, C-terminal domain; CDC6, N-domain

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.85

Protein Overview: CDC6

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: