YRC Public Data Repository - Protein Structure Prediction

Protein:	CDC6
Organism:	Saccharomyces cerevisiae
Length:	513 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC6.

Description	E-value	Query Range	Subject Range
CDC6_YEAST - Cell division control protein 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC6 PE=... CDC6 - Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex...	0.0	[1..513]	[1..513]
CDC6_PYRHO - (O57864) Cell division control protein 6 homolog (CDC6 homolog) gi\|14590068, gi\|... - gi\|3256510\|dbj\|BAA29193.1\| 437aa long hypothetical protein [Pyrococcus horikoshii OT3], gi\|14590068\|...	9.0E-77	[45..508]	[23..424]
gi\|5457555, gi\|1... - gi\|5457555\|emb\|CAB49046.1\| Cdc6/orc1 cell division control protein 6 [Pyrococcus abyssi GE5], gi\|145... CDC6_PYRAB - (Q9V2F2) Cell division control protein 6 homolog (CDC6 homolog)	1.0E-75	[42..508]	[15..419]
CDC6B_ARATH - Cell division control protein 6 homolog B OS=Arabidopsis thaliana GN=CDC6B PE=2 SV=1	3.0E-75	[12..498]	[36..497]
CDC6_PYRFU - Cell division control protein 6 homolog OS=Pyrococcus furiosus GN=cdc6 PE=3 SV=1 CDC6_PYRFU - ORC1-type DNA replication protein OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / ...	1.0E-73	[45..508]	[6..407]
gi\|27355428, gi\|... - gi\|27382257\|ref\|NP_773786.1\| metalloprotease [Bradyrhizobium japonicum USDA 110], gi\|27355428\|dbj\|BA... gi\|5531227 - gi\|5531227\|emb\|CAB51029.1\| metalloprotease FtsH [Bradyrhizobium japonicum]	2.0E-73	[73..468]	[153..510]
gi\|148684227, gi... - gi\|6753368\|ref\|NP_035929.1\| cell division cycle 6 homolog isoform a [Mus musculus], gi\|4049492\|emb\|C...	4.0E-73	[5..495]	[114..574]

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Predicted Domain #1

Region A:
Residues: [1-290]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAIPITPTK RIRRNLFDDA PATPPRPLKR KKLQFTDVTP ESSPEKLQFG SQSIFLRTKA  60
   61 LLQKSSELVN LNSSDGALPA RTAEYEQVMN FLAKAISEHR SDSLYITGPP GTGKTAQLDM 120
  121 IIRQKFQSLP LSLSTPRSKD VLRHTNPNLQ NLSWFELPDG RLESVAVTSI NCISLGEPSS 180
  181 IFQKIFDSFQ DLNGPTLQIK NMQHLQKFLE PYHKKTTFVV VLDEMDRLLH ANTSETQSVR 240
  241 TILELFLLAK LPTVSFVLIG MANSLDMKDR FLSRLNLDRG LLPQTIVFQP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.39794
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [291-358]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTAEQMYEIV IQKMSSLPTI IFQPMAIKFA AKKCAGNTGD LRKLFDVLRG SIEIYELEKR  60
   61 FLLSPTRG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.39794
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [359-513]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLNSAQVPLT PTTSPVKKSY PEPQGKIGLN YIAKVFSKFV NNNSTRTRIA KLNIQQKLIL  60
   61 CTIIQSLKLN SDATIDESFD HYIKAITKTD TLAPLQRNEF LEICTILETC GLVSIKKTKC 120
  121 KGKTKRFVDK IDVDLDMREF YDEMTKISIL KPFLH

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.61
Match:	1fnnA
Description:	CDC6, C-terminal domain; CDC6, N-domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits