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Protein Overview: TPM2

General Information:
Name(s) found: TPM2 / YIL138C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 161 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck contractile ring [IDALink to PubMed article]
    Biological Process: mitochondrion inheritance [TASLink to PubMed article]
    vacuole inheritance [TASLink to PubMed article]
    budding cell isotropic bud growth [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    vesicle-mediated transport [TASLink to PubMed article]
    intracellular mRNA localization [TASLink to PubMed article]
    actin polymerization or depolymerization [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    actin filament organization [IPILink to PubMed article]
    exocytosis [TASLink to PubMed article]
    budding cell apical bud growth [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: actin lateral binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKIKEKLNS LKLESESWQE KYEELREQLK ELEQSNTEKE NEIKSLSAKN EQLDSEVEKL  60
   61 ESQLSDTKQL AEDSNNLRSN NENYTKKNQD LEQQLEDSEA KLKEAMDKLK EADLNSEQMG 120
  121 RRIVALEEER DEWEKKCEEF QSKYEEAQKE LDEIANSLEN L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Qiu et al. (2008) ABP1 ABP140 ACT1 AIP1 ARC40 ARP2 BBC1 BNI1 BNR1 BUD6 CAP1 CAP2 CDC11 CDC24 CDC3 COF1 CRN1 END3 GYL1 HOF1 HSK3 IQG1 LAS17 MLC1 MLC2 MYO2 MYO4 PEA2 PFY1 RVS161 RVS167 SAC6 SHE3 SKT5 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TPM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] PSI-BLAST 51.29073 Tropomyosin
    2 View Details [92..161] PSI-BLAST 51.29073 Tropomyosin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle