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Protein Overview: ARG4

General Information:
Name(s) found: ARG4 / YHR018C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 463 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: arginine biosynthetic process [TASLink to PubMed article]
    Molecular Function: argininosuccinate lyase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDGTQKLWG GRFTGETDPL MHLYNASLPY DYKMYKADLE GTKVYTAGLQ KLGLLTETEL  60
   61 AKIHEGLAEI KKEWDADKFV RHPNDEDIHT ANERRLGELI GRDIAGKVHT GRSRNDQVVT 120
  121 DLRIYCRDIV NDTLFPALKG LVEVLIKRAE GEIDVLMPGY THLQRAQPIR WSHWLSSYAT 180
  181 YFTEDYKRLG QILHRLNQSP LGAGALAGHP YGIDREFLAE GLGFNSVIGN SLVAVSDRDF 240
  241 IVELMFWGTL FMNHISRFAE DLIIYCTAEF GFIQLSDAYS TGSSLMPQKK NADSLELLRG 300
  301 KSGRVFGDLT GFLMSLKGIP STYDKDMQED KEPLFDCLTT VEHSMLIATG VISTLTVNKE 360
  361 KMEAALTMDM LATDLADYLV RKGVPFRETH HISGECVATA ERLGLSGIDK LTLEQYQKID 420
  421 SRFGQDLFET FNFEQSVERR DATGGTAKSA VLKQLDNLKS QLN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AAT2 ACS2 ADH4 ALA1 ARG4 AYR1 CAR2 CDC60 COR1 CPR1 CPR6 DED81 ENP1 ERG10 ERG20 ERG27 GPT2 GRS1 ILS1 LIA1 MAE1 MPC54 NAS6 OM45 PCT1 PDA1 PDC5 PET10 PET9 PIL1 PRE10 PRO3 RET2 RNR2 RTN2 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 SSZ1 SUI1 THR4 TIF34 TIF35 TPA1 TPS1 TRR1 YDL124W YNL181W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARG4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128]
    [194..241]
    [316..333]    		 PSI-BLAST 1591.0 Argininosuccinate lyase/delta-crystallin
    2 View Details [129..193]
    [242..315]
    [334..367]
    [432..463]    		 PSI-BLAST 1591.0 Argininosuccinate lyase/delta-crystallin
    3 View Details [368..431] PSI-BLAST 1591.0 Argininosuccinate lyase/delta-crystallin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • amidine-lyase activity
    		•  3.84281419858187 bayes_pls_golite062009
  • argininosuccinate lyase activity
    		•  3.58328346705456 bayes_pls_golite062009
  • catalytic activity
    		•  2.51282259572665 bayes_pls_golite062009
  • lyase activity
    		•  2.31268471569846 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  2.2046475419807 bayes_pls_golite062009
  • fumarate hydratase activity
    		•  1.8220456742683 bayes_pls_golite062009
  • histidine ammonia-lyase activity
    		•  0.948129236753279 bayes_pls_golite062009
  • binding
    		•  0.616567403608599 bayes_pls_golite062009
  • ammonia-lyase activity
    		•  0.491229595527877 bayes_pls_golite062009
  • protein binding
    		•  0.110986062813054 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle