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View Structure Prediction Details

Protein: ARG4
Organism: Saccharomyces cerevisiae
Length: 463 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARG4.

Description E-value Query
Range		 Subject
Range
ARG4 - Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
ARLY_YEAST - Argininosuccinate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARG4 PE=1 SV=2
gi|207344771 - gi|207344771|gb|EDZ71800.1| YHR018Cp-like protein [Saccharomyces cerevisiae AWRI1631]
 0.0 [1..463] [1..463]
gi|2133231 - gi|2133231|pir||S43539 argininosuccinate lyase (EC 4.3.2.1) - yeast (Saccharomyces sp.)
ARLY_SACDO - Argininosuccinate lyase OS=Saccharomyces douglasii GN=ARG4 PE=3 SV=1
ARLY_SACPA - Argininosuccinate lyase OS=Saccharomyces paradoxus GN=ARG4 PE=3 SV=1
 0.0 [1..463] [1..463]
ARLY_MOUSE - Argininosuccinate lyase OS=Mus musculus GN=Asl PE=1 SV=1
 0.0 [1..462] [1..459]
gi|220661 - gi|220661|dbj|BAA03088.1| argininosuccinate lyase [Rattus sp.]
gi|149063151, gi... - gi|67677911|gb|AAH97270.1| Asl protein [Rattus norvegicus], gi|50925427|gb|AAH78682.1| Argininosucci...
 0.0 [1..462] [1..459]
ASL - argininosuccinate lyase
 0.0 [1..462] [1..459]
ARLY_CANAX - Argininosuccinate lyase OS=Candida albicans GN=ARG4 PE=3 SV=1
 0.0 [6..463] [12..468]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 0.0 [1..462] [1..459]

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Predicted Domain #1
Region A:
Residues: [1-128] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDGTQKLWG GRFTGETDPL MHLYNASLPY DYKMYKADLE GTKVYTAGLQ KLGLLTETEL  60
   61 AKIHEGLAEI KKEWDADKFV RHPNDEDIHT ANERRLGELI GRDIAGKVHT GRSRNDQVVT 120
  121 DLRIYCRD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [194-241] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRLNQSPLGA GALAGHPYGI DREFLAEGLG FNSVIGNSLV AVSDRDFI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [316-333] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKGIPSTYDK DMQEDKEP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1591.0
Match: 1aosA_
Description: Argininosuccinate lyase/delta-crystallin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
amidine-lyase activity 3.84281419858187 bayes_pls_golite062009
argininosuccinate lyase activity 3.58328346705456 bayes_pls_golite062009
catalytic activity 2.51282259572665 bayes_pls_golite062009
lyase activity 2.31268471569846 bayes_pls_golite062009
carbon-nitrogen lyase activity 2.2046475419807 bayes_pls_golite062009
fumarate hydratase activity 1.8220456742683 bayes_pls_golite062009
histidine ammonia-lyase activity 0.948129236753279 bayes_pls_golite062009
binding 0.616567403608599 bayes_pls_golite062009
ammonia-lyase activity 0.491229595527877 bayes_pls_golite062009
protein binding 0.110986062813054 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [129-193] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVNDTLFPAL KGLVEVLIKR AEGEIDVLMP GYTHLQRAQP IRWSHWLSSY ATYFTEDYKR  60
   61 LGQIL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [242-315] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VELMFWGTLF MNHISRFAED LIIYCTAEFG FIQLSDAYST GSSLMPQKKN ADSLELLRGK  60
   61 SGRVFGDLTG FLMS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [334-367] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFDCLTTVEH SMLIATGVIS TLTVNKEKME AALT

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [432-463] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFEQSVERRD ATGGTAKSAV LKQLDNLKSQ LN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1591.0
Match: 1aosA_
Description: Argininosuccinate lyase/delta-crystallin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [368-431] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMLATDLAD YLVRKGVPFR ETHHISGECV ATAERLGLSG IDKLTLEQYQ KIDSRFGQDL  60
   61 FETF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1591.0
Match: 1aosA_
Description: Argininosuccinate lyase/delta-crystallin
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle