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Protein Overview: SPT6

General Information:
Name(s) found: SPT6 / YGR116W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1451 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    transcription elongation factor complex [IPILink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IMPLink to PubMed article]
    chromatin organization [TASLink to PubMed article]
    nucleosome assembly [IDALink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: RNA polymerase II transcription elongation factor activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEETGDSKLV PRDEEEIVND NDETKAPSEE EEGEDVFDSS EEDEDIDEDE DEARKVQEGF  60
   61 IVNDDDENED PGTSISKKRR KHKRREREED DRLSEDDLDL LMENAGVERT KASSSSGKFK 120
  121 RLKRVGDEGN AAESESDNVA ASRQDSTSKL EDFFSEDEEE EESGLRNGRN NEYGRDEEDH 180
  181 ENRNRTADKG GILDELDDFI EDDEFSDEDD ETRQRRIQEK KLLREQSIKQ PTQITGLSSD 240
  241 KIDEMYDIFG DGHDYDWALE IENEELENGN DNNEAEEEEI DEETGAIKST KKKISLQDIY 300
  301 DLEDLKKNLM TEGDMKIRKT DIPERYQELR AGITDYGNMS SEDQELERNW IAEKISVDKN 360
  361 FDANYDLTEF KEAIGNAIKF ITKENLEVPF IYAYRRNYIS SREKDGFLLT EDDLWDIVSL 420
  421 DIEFHSLVNK KDYVQRFYAE LHIDDPIVTE YFKNQNTASI AELNSLQDIY DYLEFKYANE 480
  481 INEMFINHTG KTGKKHLKNS SYEKFKASPL YQAVSDIGIS AEDVGENISS QHQIHPPVDH 540
  541 PSSKPVEVIE SILNANSGDL QVFTSNTKLA IDTVQKYYSL ELSKNTKIRE KVRSDFSKYY 600
  601 LADVVLTAKG KKEIQKGSLY EDIKYAINRT PMHFRRDPDV FLKMVEAESL NLLSVKLHMS 660
  661 SQAQYIEHLF QIALETTNTS DIAIEWNNFR KLAFNQAMDK IFQDISQEVK DNLTKNCQKL 720
  721 VAKTVRHKFM TKLDQAPFIP NVRDPKIPKI LSLTCGQGRF GADAIIAVYV NRKGDFIRDY 780
  781 KIVDNPFDKT NPEKFEDTLD NIIQSCQPNA IGINGPNPKT QKFYKRLQEV LHKKQIVDSR 840
  841 GHTIPIIYVE DEVAIRYQNS ERAAQEFPNK PPLVKYCIAL ARYMHSPLLE YANLTSEEVR 900
  901 SLSIHPHQNL LSSEQLSWAL ETAFVDIVNL VSVEVNKATD NNYYASALKY ISGFGKRKAI 960
  961 DFLQSLQRLN EPLLARQQLI THNILHKTIF MNSAGFLYIS WNEKRQKYED LEHDQLDSTR1020
 1021 IHPEDYHLAT KVAADALEYD PDTIAEKEEQ GTMSEFIELL REDPDRRAKL ESLNLESYAE1080
 1081 ELEKNTGLRK LNNLNTIVLE LLDGFEELRN DFHPLQGDEI FQSLTGESEK TFFKGSIIPV1140
 1141 RVERFWHNDI ICTTNSEVEC VVNAQRHAGA QLRRPANEIY EIGKTYPAKV IYIDYANITA1200
 1201 EVSLLDHDVK QQYVPISYSK DPSIWDLKQE LEDAEEERKL MMAEARAKRT HRVINHPYYF1260
 1261 PFNGRQAEDY LRSKERGEFV IRQSSRGDDH LVITWKLDKD LFQHIDIQEL EKENPLALGK1320
 1321 VLIVDNQKYN DLDQIIVEYL QNKVRLLNEM TSSEKFKSGT KKDVVKFIED YSRVNPNKSV1380
 1381 YYFSLNHDNP GWFYLMFKIN ANSKLYTWNV KLTNTGYFLV NYNYPSVIQL CNGFKTLLKS1440
 1441 NSSKNRMNNY R

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) SPN1 SPT6
    View Details Gavin AC, et al. (2002) CKA1 CKA2 CKB1 SPN1 SPT6
    View Details Qiu et al. (2008) CDC73 CHD1 CTR9 ELC1 ELP6 IKI3 RTF1 SPT6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SPT6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..336] PSI-BLAST 31.0 Heavy meromyosin subfragment
    2 View Details [337..658] MSA 8.534997 View MSA. No confident structure predictions are available.
    3 View Details [659..870] deduced N/A No confident structure predictions are available.
    4 View Details [871..1001] MSA 1.104997 View MSA. No confident structure predictions are available.
    5 View Details [1002..1114] deduced N/A No confident structure predictions are available.
    6 View Details [1115..1222] PSI-BLAST 14.39794 S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase
    7 View Details [1223..1374] ORFEUS 7.21 Phosphatidylinositol 3-kinase, p85-alpha subunit
    8 View Details [1375..1451] MSA 1.016979 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • nucleic acid binding
    		•  3.95080521324016 bayes_pls_golite062009
  • DNA binding
    		•  3.71771169141041 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.90653390639682 bayes_pls_golite062009
  • binding
    		•  2.85946414867169 bayes_pls_golite062009
  • telomeric DNA binding
    		•  2.51555240517937 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  2.42617682290608 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.13063800565247 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10110937001387 bayes_pls_golite062009
  • RNA binding
    		•  2.07864328706376 bayes_pls_golite062009
  • structural molecule activity
    		•  1.9177190829469 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.30343463892105 bayes_pls_golite062009
  • excinuclease ABC activity
    		•  1.24466762466323 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • transcription factor activity
    		•  1.14242112812892 bayes_pls_golite062009
  • endonuclease activity
    		•  0.991569665925888 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.95191912850966 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.85691075793641 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.708753843279937 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.598360955770972 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.583085644017496 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • protein binding
    		•  0.420735403363425 bayes_pls_golite062009
  • translation regulator activity
    		•  0.31332179848255 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.263197317040851 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.24906263529692 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.2080607201312 bayes_pls_golite062009
  • chromatin binding
    		•  0.19409870825073 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.125256208482441 bayes_pls_golite062009
  • telomerase inhibitor activity
    		•  0.111973370145519 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.109774918833391 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.09423425042945 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.0189279348688405 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.016619833072142 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  3.01525273025469 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.33050919783116 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.10577358908602 bayes_pls_golite062009
  • protein binding
    		•  1.97939552458783 bayes_pls_golite062009
  • DNA binding
    		•  1.9368694231327 bayes_pls_golite062009
  • transcription factor activity
    		•  1.23187486844263 bayes_pls_golite062009
  • molecular adaptor activity
    		•  0.136743230957381 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  0.0218958138395108 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle