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Protein Overview: TFC4

General Information:
Name(s) found: TFC4 / YGR047C [SGD]
Description(s) found:
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  • gi|6321484|ref|NP_011561.1| One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TF [NCBI NR]
  • pir||A47453 transcription factor IIIC chain TFC4 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|464876|sp|P33339.1|TFC4_YEAST RecName: Full=Transcription factor tau 131 kDa subunit; AltName: Full=TFIIIC 131 kDa subunit; AltName: Full=Transcription factor C subunit 4 [NCBI NR]
  • gi|311165|gb|AAA35145.1| transcription factor IIIB 131kDa subunit [NCBI NR]
  • gi|1323051|emb|CAA97046.1| TFC4 [Saccharomyces cerevisiae] [NCBI NR]
  • Transcription factor tau 131 kDa subunit OS=Saccharomyces cerevisiae GN=TFC4 PE=1 SV=1 [Swiss-Prot]
  • TFC4 TFIIIC (transcription initiation factor) subunit, 131 kD [mips]
  • One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 [SGD]
  • TFC4, Chr VII from 586386-589463, reverse complement [yeast_orfs2]
  • Chr VII from 586386-589463, reverse complement [yeastorf3.fasta]
  • Chr VII from 586393-589470, reverse complement [yeastorf4.fasta]
  • Chr VII from 589470-586393, reverse complement [yeastorf5.fasta]
  • (P33339) Transcription factor tau 131 kDa subunit (TFIIIC 131 kDa subunit) [4932.FASTACCERV.txt]
  • TFC4 SGDID:S0003279, Chr VII from 589471-586394, reverse complement, Verified ORF [yeastflysequest.fasta]
  • TFC4 SGDID:S0003279, Chr VII from 589473-586396, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Tfc4p [Saccharomyces cerevisiae]gi|1323051|emb|CAA97046.1| TFC4 [Saccharomyces cerevisiae]gi|464876|sp|P33339|TFC4_YEAST Transcription factor tau 131 kDa subunit (TFIIIC 131 kDa subunit)gi|476981|pir||A47453 transcription factor IIIC chain TFC4 - yeast [nrdb_11152004_Chlamydomonas]
  • TFC4 SGDID:S000003279, Chr VII from 589473-586396, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of t [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102; Tfc4p [Saccharomyc [nr-271106-contam.fasta]
  • TFC4 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • transcription factor IIIB 131kDa subunit [nr-271106-contam.fasta]
  • Transcription factor tau 131 kDa subunit (TFIIIC 131 kDa subunit) [nr-271106-contam.fasta]
  • TFC4 SGDID:S000003279, Chr VII from 589473-586396, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Transcription factor tau 131 kDa subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TFC4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TFC4 SGDID:S000003279, Chr VII from 589469-586392, Genome Release 64-1-1, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102" [yeast-030211-contam.fasta]
  • TFC4 SGDID:S000003279, Chr VII from 589469-586392, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102" [20141208_orf_trans.fasta]
  • YGR047C SGDID:S000003279, Chr VII from 589469-586392, Genome Release 64-1-1, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1025 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIIIC complex [TASLink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase III promoter [TASLink to PubMed article]
    Molecular Function: RNA polymerase III transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGKLKKEQ QNQSAERESA DTGKVNDEDE EHLYGNIDDY KHLIQDEEYD DEDVPHDLQL  60
   61 SEDEYNSERD SSLLAEFSDY GEISEDDEED FMNAIREASN FKVKKKKKND KGKSYGRQRK 120
  121 ERVLDPEVAQ LLSQANEAFV RNDLQVAERL FNEVIKKDAR NFAAYETLGD IYQLQGRLND 180
  181 CCNSWFLAAH LNASDWEFWK IVAILSADLD HVRQAIYCFS RVISLNPMEW ESIYRRSMLY 240
  241 KKTGQLARAL DGFQRLYMYN PYDANILREL AILYVDYDRI EDSIELYMKV FNANVERREA 300
  301 ILAALENALD SSDEESAAEG EDADEKEPLE QDEDRQMFPD INWKKIDAKY KCIPFDWSSL 360
  361 NILAELFLKL AVSEVDGIKT IKKCARWIQR RESQTFWDHV PDDSEFDNRR FKNSTFDSLL 420
  421 AAEKEKSYNI PIDIRVRLGL LRLNTDNLVE ALNHFQCLYD ETFSDVADLY FEAATALTRA 480
  481 EKYKEAIDFF TPLLSLEEWR TTDVFKPLAR CYKEIESYET AKEFYELAIK SEPDDLDIRV 540
  541 SLAEVYYRLN DPETFKHMLV DVVEMRKHQV DETLHRISNE KSSNDTSDIS SKPLLEDSKF 600
  601 RTFRKKKRTP YDAERERIER ERRITAKVVD KYEKMKKFEL NSGLNEAKQA SIWINTVSEL 660
  661 VDIFSSVKNF FMKSRSRKFV GILRRTKKFN TELDFQIERL SKLAEGDSVF EGPLMEERVT 720
  721 LTSATELRGL SYEQWFELFM ELSLVIAKYQ SVEDGLSVVE TAQEVNVFFQ DPERVKMMKF 780
  781 VKLAIVLQMD DEEELAENLR GLLNQFQFNR KVLQVFMYSL CRGPSSLNIL SSTIQQKFFL 840
  841 RQLKAFDSCR YNTEVNGQAS ITNKEVYNPN KKSSPYLYYI YAVLLYSSRG FLSALQYLTR 900
  901 LEEDIPDDPM VNLLMGLSHI HRAMQRLTAQ RHFQIFHGLR YLYRYHKIRK SLYTDLEKQE 960
  961 ADYNLGRAFH LIGLVSIAIE YYNRVLENYD DGKLKKHAAY NSIIIYQQSG NVELADHLME1020
 1021 KYLSI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details (MIPS) Mewes HW, et al. (2004) TFC1 TFC3 TFC4 TFC6 TFC7
    View Details Krogan NJ, et al. (2006) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Gavin AC, et al. (2006) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Gavin AC, et al. (2002) ITC1 TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Ho Y, et al. (2002) BUD14 CMP2 DOG1 GIS4 HSP104 KEL1 KEL2 KIN2 KRE6 POP2 TEF4 TFC4 UBA1
    View Details Qiu et al. (2008) BDP1 BRF1 PZF1 SPT15 SSL1 TAF2 TFA1 TFB5 TFC1 TFC3 TFC4 TFC6 TFC7 TFC8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TFC4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..67] PSI-BLAST 34.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    2 View Details [68..403] PSI-BLAST 4.69897 Clathrin heavy chain proximal leg segment
    3 View Details [404..541] PSI-BLAST 2.09691 Vesicular transport protein sec17
    4 View Details [542..644] MSA 2.742997 View MSA. No confident structure predictions are available.
    5 View Details [645..729] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [730..824] ORFEUS 13.05 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    7 View Details [825..925] ORFEUS 13.05 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    8 View Details [926..1025] ORFEUS 13.05 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  3.17166650775207 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36976362065221 bayes_pls_golite062009
  • DNA binding
    		•  1.72247907299633 bayes_pls_golite062009
  • protein binding
    		•  1.72061787550863 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.63537681687141 bayes_pls_golite062009
  • transcription factor activity
    		•  1.0205750374806 bayes_pls_golite062009
  • transcription factor binding
    		•  0.447234745044969 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.201108481303385 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.0645101607447045 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0514451541233234 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle