YRC Public Data Repository - Protein Structure Prediction

Protein:	TFC4
Organism:	Saccharomyces cerevisiae
Length:	1025 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TFC4.

Description	E-value	Query Range	Subject Range
TFC4_YEAST - Transcription factor tau 131 kDa subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... gi\|151943329 - gi\|151943329\|gb\|EDN61642.1\| tau 131 subunit of transcription factor TFIIIC [Saccharomyces cerevisiae... gi\|207345198 - gi\|207345198\|gb\|EDZ72095.1\| YGR047Cp-like protein [Saccharomyces cerevisiae AWRI1631] TFC4 - One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part...	0.0	[1..1025]	[1..1025]
gi\|50304701, gi\|... - gi\|50304701\|ref\|XP_452306.1\| unnamed protein product [Kluyveromyces lactis], gi\|49641439\|emb\|CAH0115... gi\|12656113, gi\|... - gi\|49641439\|emb\|CAH01157.1\| KLLA0C02453p [Kluyveromyces lactis], gi\|12656113\|gb\|AAK00752.1\|AF229182_...	0.0	[28..1025]	[6..1028]
sfc4 - transcription factor TFIIIC complex subunit Sfc4 SFC4_SCHPO - Transcription factor tau subunit sfc4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sfc4...	0.0	[9..1023]	[16..1004]
gi\|25511644, gi\|... - gi\|9802741\|gb\|AAF99810.1\|AC034257_2 Unknown protein [Arabidopsis thaliana], pir\|\|F86311 F11A6.2 prot...	2.0E-98	[313..1024]	[88..814]
gi\|19171000, gi\|... - gi\|19173411\|ref\|NP_597214.1\| TRANSCRIPTION FACTOR TAU-LIKE PROTEIN (TFIIIC-LIKE PROTEIN) [Encephalit... gi\|19173411 - gi\|19173411\|ref\|NP_597214.1\| TRANSCRIPTION FACTOR TAU-LIKE PROTEIN (TFIIIC-LIKE PROTEIN) [Encephalit...	9.0E-88	[230..1014]	[42..787]
gi\|13775066 - gi\|13775066\|gb\|AAK39123.1\|AF363030_1 UDP-N-acetylglucosaminyltransferase [Mus musculus]	1.0E-83	[89..571]	[22..498]
OGT1_RAT - UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicu...	1.0E-83	[87..571]	[10..488]
OGT - O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylgluco... gi\|123993895, gi... - gi\|224487755\|dbj\|BAH24112.1\| O-linked N-acetylglucosamine (GlcNAc) transferase [synthetic construct]...	2.0E-83	[87..571]	[10..488]
gi\|5052534 - gi\|5052534\|gb\|AAD38597.1\|AF145622_1 BcDNA.GH04245 [Drosophila melanogaster]	4.0E-81	[86..571]	[43..527]
ogt-1 - status:Confirmed UniProt:O18158 protein_id:AAA62535.2	9.0E-81	[94..569]	[131..600]

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Predicted Domain #1

Region A:
Residues: [1-67]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGKLKKEQ QNQSAERESA DTGKVNDEDE EHLYGNIDDY KHLIQDEEYD DEDVPHDLQL  60
   61 SEDEYNS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.0
Match:	1fchA_
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [68-403]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERDSSLLAEF SDYGEISEDD EEDFMNAIRE ASNFKVKKKK KNDKGKSYGR QRKERVLDPE  60
   61 VAQLLSQANE AFVRNDLQVA ERLFNEVIKK DARNFAAYET LGDIYQLQGR LNDCCNSWFL 120
  121 AAHLNASDWE FWKIVAILSA DLDHVRQAIY CFSRVISLNP MEWESIYRRS MLYKKTGQLA 180
  181 RALDGFQRLY MYNPYDANIL RELAILYVDY DRIEDSIELY MKVFNANVER REAILAALEN 240
  241 ALDSSDEESA AEGEDADEKE PLEQDEDRQM FPDINWKKID AKYKCIPFDW SSLNILAELF 300
  301 LKLAVSEVDG IKTIKKCARW IQRRESQTFW DHVPDD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.69897
Match:	1b89A_
Description:	Clathrin heavy chain proximal leg segment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [404-541]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEFDNRRFKN STFDSLLAAE KEKSYNIPID IRVRLGLLRL NTDNLVEALN HFQCLYDETF  60
   61 SDVADLYFEA ATALTRAEKY KEAIDFFTPL LSLEEWRTTD VFKPLARCYK EIESYETAKE 120
  121 FYELAIKSEP DDLDIRVS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2.09691
Match:	1qqeA_
Description:	Vesicular transport protein sec17
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	3.17166650775207	bayes_pls_golite062009
transcription regulator activity	2.36976362065221	bayes_pls_golite062009
DNA binding	1.72247907299633	bayes_pls_golite062009
protein binding	1.72061787550863	bayes_pls_golite062009
nucleic acid binding	1.63537681687141	bayes_pls_golite062009
transcription factor activity	1.0205750374806	bayes_pls_golite062009
transcription factor binding	0.447234745044969	bayes_pls_golite062009
transcription cofactor activity	0.201108481303385	bayes_pls_golite062009
transcription coactivator activity	0.0645101607447045	bayes_pls_golite062009
transcription activator activity	0.0514451541233234	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [542-644]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAEVYYRLND PETFKHMLVD VVEMRKHQVD ETLHRISNEK SSNDTSDISS KPLLEDSKFR  60
   61 TFRKKKRTPY DAERERIERE RRITAKVVDK YEKMKKFELN SGL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [645-729]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEAKQASIWI NTVSELVDIF SSVKNFFMKS RSRKFVGILR RTKKFNTELD FQIERLSKLA  60
   61 EGDSVFEGPL MEERVTLTSA TELRG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.845	0.096	RNA polymerase III transcription factor activity	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like

Predicted Domain #6

Region A:
Residues: [730-824]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSYEQWFELF MELSLVIAKY QSVEDGLSVV ETAQEVNVFF QDPERVKMMK FVKLAIVLQM  60
   61 DDEEELAENL RGLLNQFQFN RKVLQVFMYS LCRGP

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.05
Match:	1fchA
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [825-925]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLNILSSTI QQKFFLRQLK AFDSCRYNTE VNGQASITNK EVYNPNKKSS PYLYYIYAVL  60
   61 LYSSRGFLSA LQYLTRLEED IPDDPMVNLL MGLSHIHRAM Q

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.05
Match:	1fchA
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [926-1025]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLTAQRHFQI FHGLRYLYRY HKIRKSLYTD LEKQEADYNL GRAFHLIGLV SIAIEYYNRV  60
   61 LENYDDGKLK KHAAYNSIII YQQSGNVELA DHLMEKYLSI

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.05
Match:	1fchA
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: