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Protein Overview: SSF2

General Information:
Name(s) found: SSF2 / YDR312W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 453 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: conjugation with cellular fusion [IGILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    ribosomal large subunit assembly [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: rRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKRRQKKRT HAQITPEQER DIPKSMVIRV GQTSLANHSL NQLVKDFRQI MQPHTAVKLK  60
   61 ERKSNKLKDF VVMCGPLGVT HLFMFTQSEK TGNVSLKIAR TPQGPTVTFQ VLDYSLGRDI 120
  121 KKFLKRPKSL NNDDVLNPPL LVLNGFSTSK RSDEDDQDVN VEKVIVSMFQ NIFPPLNPAR 180
  181 TSLNSIKRIF MINKDRETGE ISMRHYFIDI REVEISRNLK RLYKAKNNLS KTVPNLHRKE 240
  241 DISSLILDHD LGAYTSESEI EDDAIVRVVD NQDVKAKHSQ TSLSQKTPVK MTDNEEREKG 300
  301 IEEEDVEMEE PKPSENSQPT PRKKAIKLTE LGPRLTLKLV KIEDGICSGK VLHHEFVQKS 360
  361 SEEIKALEKR HAAKMRLKEQ RRKEQEENIA KKKAVKDAKK QRKLERRKAR AEEQGEGQGK 420
  421 DGAMSDDGSS SSEDEHYSDV PEDLDSDLFS EVE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) RRP14 RRP15 SSF1 SSF2 URB1
    View Details Ho Y, et al. (2002) BMS1 CDC53 CIC1 COF1 CTF4 DBP10 DED81 DIA2 ENP1 FPR3 ILS1 KRE33 KRI1 LST4 MCM2 MCM3 MCM5 NIP7 NMD3 NOP12 RRP12 SEH1 SKP1 SLT2 SPB1 SSF1 SSF2 SSZ1 TIF6 URB1 UTP10 YAK1 YBL104C
    View Details Qiu et al. (2008) SSF1 SSF2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SSF2 and NOP56 Huh WK, et al. (2003)
    View Data SSF2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..225] FFAS03 4.09 Crystal structure of probable ribosomal biogenesis protein from Aeropyrum pernix K1
    2 View Details [226..384] deduced N/A No confident structure predictions are available.
    3 View Details [385..453] MSA 2.032991 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle