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Protein Overview: CSN9

General Information:
Name(s) found: CSN9 / YDR179C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 162 amino acids

    Gene Ontology:
    Cellular Component: signalosome [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: protein deneddylation [IMPLink to PubMed articleLink to PubMed article]
    adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVMREETIKS LEDPYKYHYK EEWLNTKDPD EQQLFEIFAF GNIKDLPENI ILTSLMRSKL  60
   61 EKLTLVTLSE IYNELSYELI KEECQIEDDG IIESHLIQLQ NIFKAEMDSV SKSMKFSRRF 120
  121 DCRDVYCHEK ELTIIKNPRV TKEYLVQNLR SWETKLKQNI LE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CSI1 CSN9 PCI8 RPN5 RRI1 RRI2
    View Details (MIPS) Mewes HW, et al. (2004) CSN12 CSN9
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Gavin AC, et al. (2006) CSI1 CSN9 PCI8 RRI1 RRI2
    View Details Gavin AC, et al. (2002) CSI1 CSN9 PCI8 RPN5 RRI1 RRI2
    View Details Qiu et al. (2008) CSI1 CSN12 CSN9 PCI8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RPN5 CSN9 2 Uetz P, et al. (2000)
    View Screen GPA1 CSN9 2 Unpublished Fields Lab Data
    View Screen CDC48 CSN9 1 Unpublished Fields Lab Data
    View Screen CDC53 CSN9 1 Unpublished Fields Lab Data
    View Screen TAM41 CSN9 1 Unpublished Fields Lab Data
    View Screen PPT1 CSN9 1 Unpublished Fields Lab Data
    View Screen ATG7 CSN9 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CSN9 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] FFAS03 1.26 Solution structure of the PCI domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle