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Protein Overview: POL4

General Information:
Name(s) found: POL4 / YCR014C [SGD]
Description(s) found:
Found 23 descriptions.
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  • DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 582 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    Biological Process: base-excision repair, gap-filling [TASLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IDALink to PubMed article]
    double-strand break repair [IDALink to PubMed article]
    Molecular Function: DNA binding [IEA]
    DNA-directed DNA polymerase activity [IEA][TAS]
    nucleotidyltransferase activity [IEA]
    catalytic activity [IEA]
    metal ion binding [IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKGKFFAF LPNPNTSSNK FFKSILEKKG ATIVSSIQNC LQSSRKEVVI LIEDSFVDSD  60
   61 MHLTQKDIFQ REAGLNDVDE FLGKIEQSGI QCVKTSCITK WVQNDKFAFQ KDDLIKFQPS 120
  121 IIVISDNADD GQSSTDKESE ISTDVESERN DDSNNKDMIQ ASKPLKRLLQ GDKGRASLVT 180
  181 DKTKYKNNEL IIGALKRLTK KYEIEGEKFR ARSYRLAKQS MENCDFNVRS GEEAHTKLRN 240
  241 IGPSIAKKIQ VILDTGVLPG LNDSVGLEDK LKYFKNCYGI GSEIAKRWNL LNFESFCVAA 300
  301 KKDPEEFVSD WTILFGWSYY DDWLCKMSRN ECFTHLKKVQ KALRGIDPEC QVELQGSYNR 360
  361 GYSKCGDIDL LFFKPFCNDT TELAKIMETL CIKLYKDGYI HCFLQLTPNL EKLFLKRIVE 420
  421 RFRTAKIVGY GERKRWYSSE IIKKFFMGVK LSPRELEELK EMKNDEGTLL IEEEEEEETK 480
  481 LKPIDQYMSL NAKDGNYCRR LDFFCCKWDE LGAGRIHYTG SKEYNRWIRI LAAQKGFKLT 540
  541 QHGLFRNNIL LESFNERRIF ELLNLKYAEP EHRNIEWEKK TA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GSG1 POL4 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN3 RPN5 RPN6 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SEM1 SLX5 SPG5 SWA2 UBP6
    View Details Krogan NJ, et al. (2006) ARI1 POL4 ROK1
    View Details Ho Y, et al. (2002) POL4 RHO5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen POL4 PET494 2 Unpublished Fields Lab Data
    View Screen PRP42 POL4 1 Unpublished Fields Lab Data
    View Screen POL4 ROX3 1 Unpublished Fields Lab Data
    View Screen POL4 NRP1 1 Unpublished Fields Lab Data
    View Screen POL4 SNF11 1 Unpublished Fields Lab Data
    View Screen POL4 ACA1 1 Unpublished Fields Lab Data
    View Screen POL4 SPT10 1 Unpublished Fields Lab Data
    View Screen POL4 YJR023C 1 Unpublished Fields Lab Data
    View Screen POL4 RPC34 1 Unpublished Fields Lab Data
    View Screen POL4 NFI1 1 Unpublished Fields Lab Data
    View Screen POL4 NCA2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] MSA 1.015993 View MSA. No confident structure predictions are available.
    2 View Details [92..149] deduced N/A No confident structure predictions are available.
    3 View Details [150..264] PSI-BLAST 216.0103 Terminal deoxynucleotidyl transferase
    4 View Details [265..318] PSI-BLAST 216.0103 Terminal deoxynucleotidyl transferase
    5 View Details [319..582] PSI-BLAST 216.0103 Terminal deoxynucleotidyl transferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA polymerase activity
    		•  1.73758028049287 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  1.72676695496584 bayes_pls_golite062009
  • catalytic activity
    		•  0.60409960326459 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle