YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SPT10

General Information:
Name(s) found: SPT10 / YJL127C [SGD]
Description(s) found:
Found 28 descriptions.
SHOW ALL
  • Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and highly cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 640 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    chromatin remodeling [TASLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter, global [TASLink to PubMed article]
    Molecular Function: histone acetyltransferase activity [IDALink to PubMed article]
    sequence-specific DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNQHTSSVP DDEHLQMAHQ NSSSEVRNEA AVPDQLLTPL QPYTILLKDG ETIATMYPIP  60
   61 AYPDLLPLGL LNFLLDEFNM EVEKGDSFPY YETLSLEEFK NVWFHNDGHV CIMVLGEIPE 120
  121 LDYSMDTEAD TNDNFGTEIE TTKHTTQYKK RKERRNLNLS MQWEKQCLGI FDLKPAYPGR 180
  181 SAHVVTGTFL VNAGIRGKGI GKTLMETFIE WSKKLGFTSS FFPLIYGTNV GIRRILEGLN 240
  241 FRRIGKLPEA GILKGFDVPV DSFMYGKEFT HITKSIDLLR DPQKSIEIGK YERLKHFLET 300
  301 GKYPLHCDRN EKARLRVLSK THSVLNGKLM TKGKEIIYDT DQQIQIALEI HLMEHLGINK 360
  361 VTSKIGEKYH WRGIKSTVSE VISRCQKCKM RYKDGTGVII EQKRAVKQAH MLPTQHIETI 420
  421 NNPRKSKKHD NALLGQAINF PQNIISSTLN DVEGEPTPPD TNIVQPTFQN ATNSPATTAE 480
  481 ANEANKRSEF LSSIQSTPLL DDEQSMNSFN RFVEEENSRK RRKYLDVASN GIVPHLTNNE 540
  541 SQDHANPVNR DERDMNHSVP DLDRNDHTIM NDAMLSLEDN VMAALEMVQK EQQQKINHRG 600
  601 EDVTGQQIDL NNSEGNENSV TKIVNNESNT FTEHNSNIYY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SPT10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] deduced N/A No confident structure predictions are available.
    2 View Details [89..309] PSI-BLAST 7.221849 Aminoglycoside 6'-N-acetyltransferase
    3 View Details [310..397] ORFEUS 8.53 N-terminal Zn binding domain of HIV integrase; Retroviral integrase, catalytic domain
    4 View Details [398..640] ORFEUS 8.53 N-terminal Zn binding domain of HIV integrase; Retroviral integrase, catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  4.32406263750499 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.26078833573813 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  4.12956006910653 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  4.12956006910653 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.10399129332319 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.24760844790231 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13750665291344 bayes_pls_golite062009
  • catalytic activity
    		•  1.97933499002461 bayes_pls_golite062009
  • transferase activity
    		•  1.72447231774431 bayes_pls_golite062009
    		• 1.69317676984704 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  1.47571666298157 bayes_pls_golite062009
  • acyltransferase activity
    		•  1.47230586550141 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.42711272311757 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.31507488567214 bayes_pls_golite062009
  • binding
    		•  1.22537494136129 bayes_pls_golite062009
  • transcription factor binding
    		•  1.13174003342838 bayes_pls_golite062009
  • transcription activator activity
    		•  0.891911076312861 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.605899196605446 bayes_pls_golite062009
  • histone binding
    		•  0.582104626133107 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.31196049232138 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.17675473564653 bayes_pls_golite062009
  • protein binding
    		•  0.075825416385311 bayes_pls_golite062009
    3
    Term Confidence Notes
  • exonuclease activity
    		•  2.24517802933873 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.22832306273638 bayes_pls_golite062009
  • nuclease activity
    		•  2.17049593048518 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.15202443486046 bayes_pls_golite062009
  • DNA binding
    		•  1.88388568255929 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.7264885813713 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.54823157746404 bayes_pls_golite062009
  • binding
    		•  1.42021256417703 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.23245248968126 bayes_pls_golite062009
  • transcription factor activity
    		•  1.18792852183348 bayes_pls_golite062009
  • catalytic activity
    		•  1.16880796007849 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.819269466567015 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.618022514104206 bayes_pls_golite062009
  • endonuclease activity
    		•  0.591008475846166 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.470156503599777 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.445309350267778 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.330636967059347 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.283617295697939 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.244405458380391 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.211534069092691 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.152950127352174 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0924765766526223 bayes_pls_golite062009
  • protein binding
    		•  0.0799098348667361 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle