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View Structure Prediction Details

Protein: POL4
Organism: Saccharomyces cerevisiae
Length: 582 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POL4.

Description E-value Query
Range
Subject
Range
POL4 - DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of...
DPO4_YEAST - DNA polymerase IV OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POL4 PE=1 SV=4
0.0 [1..582] [1..582]
gi|112734841, gi... - gi|74137150|dbj|BAE21978.1| unnamed protein product [Mus musculus], gi|12802443|gb|AAK07885.1|AF3160...
0.0 [27..574] [13..509]
TDT_MONDO - DNA nucleotidylexotransferase OS=Monodelphis domestica GN=DNTT PE=2 SV=1
0.0 [27..574] [13..517]
TDT_BOVIN - DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltra...
0.0 [27..574] [24..519]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [27..574] [24..546]
gi|123981124, gi... - gi|123995939|gb|ABM85571.1| deoxynucleotidyltransferase, terminal [synthetic construct], gi|12398112...
DNTT - deoxynucleotidyltransferase, terminal
0.0 [27..574] [17..508]
TDT_XENLA - DNA nucleotidylexotransferase OS=Xenopus laevis GN=dntt PE=2 SV=1
0.0 [26..574] [12..506]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKGKFFAF LPNPNTSSNK FFKSILEKKG ATIVSSIQNC LQSSRKEVVI LIEDSFVDSD  60
   61 MHLTQKDIFQ REAGLNDVDE FLGKIEQSGI Q

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CVKTSCITKW VQNDKFAFQK DDLIKFQPSI IVISDNADDG QSSTDKESEI STDVESER

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
DNA polymerase activity 1.73758028049287 bayes_pls_golite062009
DNA-directed DNA polymerase activity 1.72676695496584 bayes_pls_golite062009
catalytic activity 0.60409960326459 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [150-264]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDDSNNKDMI QASKPLKRLL QGDKGRASLV TDKTKYKNNE LIIGALKRLT KKYEIEGEKF  60
   61 RARSYRLAKQ SMENCDFNVR SGEEAHTKLR NIGPSIAKKI QVILDTGVLP GLNDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 216.0103
Match: 1jmsA_
Description: Terminal deoxynucleotidyl transferase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [265-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGLEDKLKYF KNCYGIGSEI AKRWNLLNFE SFCVAAKKDP EEFVSDWTIL FGWS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 216.0103
Match: 1jmsA_
Description: Terminal deoxynucleotidyl transferase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [319-582]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YYDDWLCKMS RNECFTHLKK VQKALRGIDP ECQVELQGSY NRGYSKCGDI DLLFFKPFCN  60
   61 DTTELAKIME TLCIKLYKDG YIHCFLQLTP NLEKLFLKRI VERFRTAKIV GYGERKRWYS 120
  121 SEIIKKFFMG VKLSPRELEE LKEMKNDEGT LLIEEEEEEE TKLKPIDQYM SLNAKDGNYC 180
  181 RRLDFFCCKW DELGAGRIHY TGSKEYNRWI RILAAQKGFK LTQHGLFRNN ILLESFNERR 240
  241 IFELLNLKYA EPEHRNIEWE KKTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 216.0103
Match: 1jmsA_
Description: Terminal deoxynucleotidyl transferase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle