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View Structure Prediction Details

Protein: wht-2
Organism: Caenorhabditis elegans
Length: 610 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for wht-2.

Description E-value Query
Range		 Subject
Range
gi|66850438, gi|... - gi|70996096|ref|XP_752803.1| ABC transporter [Aspergillus fumigatus Af293], gi|66850438|gb|EAL90765....
gi|159131557 - gi|159131557|gb|EDP56670.1| ABC transporter, putative [Aspergillus fumigatus A1163]
gi|44890030 - gi|44890030|emb|CAF32148.1| ABC transporter, putative [Aspergillus fumigatus]
 476.0 [0..4] [610..823]

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Predicted Domain #1
Region A:
Residues: [1-332] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATETCSLLS VGQSEYGAAA SMISALEAVD PVTLTWHNIS IHAEKSGKQI LENVSGIAKP  60
   61 GQLLALMGAS GAGKTTLLNM LLSRNLRGLE TSGSVKVNGH ELGRGITAIS GYAQQDELFV 120
  121 GTLTVKEYLD IQAKLRVNGD SEKRRRRVGN VMSQLGLYKC QNTRIGTIGG QKGISGGEMR 180
  181 RLTFACELLS NPSILFCDEP TTGLDSFMAE SVVQVLSNLA KSGRTVICTI HQPSSQLYLM 240
  241 FDRVMFMAGG KTAFLGSPRD AIQFFEDAGF ACPRNFNPAD LIIHTLAVMP NEEDKCRQRI 300
  301 EVIYTKFQNS SYGRTLKFGV EKSDEGQRPS ER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.69897
Match: 1v43A
Description: Crystal Structure of ATPase subunit of ABC Sugar Transporter
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity 6.58863529263644 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 6.58067278719409 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 6.57974651657836 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 6.57922174989907 bayes_pls_golite062009
primary active transmembrane transporter activity 6.57807080367604 bayes_pls_golite062009
nucleoside-triphosphatase activity 6.48406410175216 bayes_pls_golite062009
active transmembrane transporter activity 6.48154954364331 bayes_pls_golite062009
pyrophosphatase activity 6.40467109535527 bayes_pls_golite062009
ATPase activity, coupled 6.40151534181487 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 6.38373914253885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.38247436082206 bayes_pls_golite062009
ATPase activity 6.30019941712404 bayes_pls_golite062009
hydrolase activity 5.13885856289543 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 4.44979714930206 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 4.35344629015015 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
purine ribonucleotide binding 3.40690615950081 bayes_pls_golite062009
ribonucleotide binding 3.40594996232845 bayes_pls_golite062009
purine nucleotide binding 3.3669118613715 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
nucleotide binding 3.33248266870364 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.19399273923292 bayes_pls_golite062009
ATP binding 3.17398570826788 bayes_pls_golite062009
anion transmembrane transporter activity 3.13913638619234 bayes_pls_golite062009
adenyl ribonucleotide binding 3.12628113185041 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
adenyl nucleotide binding 3.0710107594224 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.9271291809464 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
cholesterol transporter activity 2.72457626066894 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.63419811368692 bayes_pls_golite062009
sterol transporter activity 2.48406559423479 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
binding 2.21604035604783 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
eye pigment precursor transporter activity 2.19742277986318 bayes_pls_golite062009
lipopolysaccharide transmembrane transporter activity 1.92426772294655 bayes_pls_golite062009
lipopolysaccharide-transporting ATPase activity 1.92426772294655 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
polysaccharide transmembrane transporter activity 1.87680514870933 bayes_pls_golite062009
molybdate ion transmembrane transporter activity 1.86846760797799 bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity 1.86846760797799 bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity 1.85247645478102 bayes_pls_golite062009
organic anion transmembrane transporter activity 1.76999970080179 bayes_pls_golite062009
potassium channel activity 1.68725597823541 bayes_pls_golite062009
phosphate transmembrane transporter activity 1.66974470564566 bayes_pls_golite062009
nucleic acid binding 1.62884148289979 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
DNA binding 1.53176391519962 bayes_pls_golite062009
transcription regulator activity 1.49517431175162 bayes_pls_golite062009
phosphonate transmembrane transporter activity 1.40269234722336 bayes_pls_golite062009
peptide-transporting ATPase activity 1.37783759788533 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
sterol-transporting ATPase activity 1.30536878174919 bayes_pls_golite062009
glycoprotein transporter activity 1.30536878174919 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
peptide transporter activity 1.19353064661766 bayes_pls_golite062009
lipid transporter activity 1.10957173853622 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
iron ion transmembrane transporter activity 0.959018069837069 bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity 0.955327639402151 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
phospholipid transporter activity 0.755445322666929 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
molybdenum ion binding 0.52244052788317 bayes_pls_golite062009
protein transporter activity 0.498432226280822 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 0.442220326523999 bayes_pls_golite062009
transcription factor activity 0.344643343870781 bayes_pls_golite062009
apolipoprotein receptor activity 0.310540417068989 bayes_pls_golite062009
syntaxin-13 binding 0.310540417068989 bayes_pls_golite062009
apolipoprotein A-I binding 0.310540417068989 bayes_pls_golite062009
apolipoprotein A-I receptor activity 0.310540417068989 bayes_pls_golite062009
signal transducer activity 0.286367085584159 bayes_pls_golite062009
molecular transducer activity 0.286367085584159 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.219473333671469 bayes_pls_golite062009
G-protein coupled receptor activity 0.169034229773346 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
transcription activator activity 0.0291047953833683 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [333-610] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKTGILTQIG ALLERSAIDT WRNPSLTRAK VIQKSIMGLF IGLLYLQSPL TSIGISNLNG  60
   61 ALFYLVCELT YSTIFGILNF LPADFPLVSR EYHDGLYSVF SYYVARCLSY LPLFTADGLI 120
  121 MLLVSYWMVG FSSSITQVLY ACLIAFLIEQ SSSACGIMIS CISPSLPIAM STAGPMLTLL 180
  181 SLTGGLYANV GALPSYISWI QYLSWFRYGF EAFAINQWSS VNEQNTTIWT DEKRDSVLSQ 240
  241 LSFRAEMFYP DLFIMSAFIL IFYTIGYAGL ALRVSKAR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle