YRC Public Data Repository - Protein Structure Prediction

Protein:	sid2
Organism:	Schizosaccharomyces pombe
Length:	607 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sid2.

Description	E-value	Query Range	Subject Range
gi\|39970581, gi\|... - gi\|39970581\|ref\|XP_366681.1\| hypothetical protein MGG_02757 [Magnaporthe grisea 70-15], gb\|EAA47514....	264.0	[0..2]	[607..53]
gi\|46128515, gi\|... - gi\|46128515\|ref\|XP_388811.1\| hypothetical protein FG08635.1 [Gibberella zeae PH-1], gi\|42549820\|gb\|E...	260.0	[0..8]	[606..59]
gi\|85115540 - gi\|85115540\|ref\|XP_964888.1\| hypothetical protein NCU09071 [Neurospora crassa OR74A] gi\|28926685, gi\|... - gi\|32422039\|ref\|XP_331463.1\| hypothetical protein [Neurospora crassa], gi\|28926685\|gb\|EAA35652.1\| co...	260.0	[0..152]	[607..243]
gi\|22135803, gi\|... - gi\|30682811\|ref\|NP_849380.1\| protein kinase family protein [Arabidopsis thaliana], gi\|30682806\|ref\|N...	259.0	[0..178]	[606..89]
gi\|46099351, gi\|... - gi\|71018725\|ref\|XP_759593.1\| hypothetical protein UM03446.1 [Ustilago maydis 521], ref\|XP_401061.1\| ...	256.0	[0..174]	[606..133]
gi\|110761240 - gi\|110761240\|ref\|XP_396874.3\| PREDICTED: similar to Akt1 CG4006-PA, isoform A [Apis mellifera]	254.0	[0..203]	[589..179]
gi\|92887515 - gi\|92887515\|gb\|ABE88922.1\| Serine/threonine protein kinase [Medicago truncatula]	253.0	[0..181]	[607..81]

Back

Predicted Domain #1

Region A:
Residues: [1-519]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRVNDMSPV EGDLGLQLSS EADKKFDAYM KRHGLFEPGN LSNNDKERNL EDQFNSMKLS  60
   61 PVASSKENYP DNHMHSKHIS KLPIASPIPR GLDRSGELSY KDNNHWSDRS STGSPRWENG 120
  121 SMNLSVEEME KVVQPKVKRM ATICQMFFLD HYFEQLHYLY TRKQRARLFE EQLLKEPDSR 180
  181 RDELVKRYNG RERVYLRKRR TRISHGDFQT ITQVGQGGYG SVWLARKRDT KEIVALKIMN 240
  241 KSVLHKMDEI RHVLTERDIL TTANSEWLVR LLYAFQDTSN IYLAMEFVPG GDFRTLLSNS 300
  301 GVLRDHHAKF YATEMFLAID ALHQLGYIHR DLKPENFLVG ASGHIKLTDF GLSSGIISKK 360
  361 KIESMKIRLQ EVNNVVVPER SMRERRQVFR TLLSQDPVYA HSVVGSPDYM APEVLRGENY 420
  421 NHSVDYWSLG CIMYECLSGF PPFSGSNVNE TWSNLKNWRK CFQRPHYDDP RDLEFNWRDD 480
  481 AWDFVCHCIT DPKDRFCSLK QVMQHPYFSK IDWKNVRTA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.09691
Match:	2fo0A
Description:	No description for 2fo0A was found.

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity	4.97855712164511	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cAMP-dependent protein kinase activity	4.66277812893755	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
calmodulin-dependent protein kinase activity	4.31938467136214	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
telethonin binding	3.2353379714316	bayes_pls_golite062009
actin binding	2.91722352767433	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
transmembrane receptor protein kinase activity	2.54265774272269	bayes_pls_golite062009
ion transmembrane transporter activity	2.52531786618214	bayes_pls_golite062009
cation transmembrane transporter activity	2.46424348876434	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.37122853419919	bayes_pls_golite062009
alpha-actinin binding	2.35173109437122	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	2.16831387024372	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
actinin binding	1.9551115853924	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.9016235206634	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
acetylcholine receptor activator activity	1.83545227594542	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.82515074380651	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
actin filament binding	1.75933904320288	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
JUN kinase kinase kinase kinase activity	1.55257528159541	bayes_pls_golite062009
phosphoinositide 3-kinase activity	1.5013287968167	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
1-phosphatidylinositol-3-kinase activity	1.43713739644553	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
gamma-tubulin binding	1.28511591054866	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.28428643482914	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
ErbB-3 class receptor binding	1.25765701903393	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
cation channel activity	1.04999722123563	bayes_pls_golite062009
ErbB-2 class receptor binding	1.02996109010965	bayes_pls_golite062009
transcription activator activity	0.997272622653026	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
sequence-specific DNA binding	0.925299895386908	bayes_pls_golite062009
growth factor binding	0.86076618871384	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.835012681606991	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.835012681606991	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.832111648073981	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
structural constituent of muscle	0.767275562047313	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
phosphoprotein phosphatase inhibitor activity	0.692834164721026	bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity	0.688047400629641	bayes_pls_golite062009
vinculin binding	0.666656406096231	bayes_pls_golite062009
ligase activity	0.665445021164512	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
transcription repressor activity	0.568332175782799	bayes_pls_golite062009
JUN kinase kinase kinase activity	0.55273442833601	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.401250804041384	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
phosphatase inhibitor activity	0.375510847180955	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
channel activity	0.287189255116606	bayes_pls_golite062009
passive transmembrane transporter activity	0.287189255116606	bayes_pls_golite062009
structure-specific DNA binding	0.267404531445803	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
substrate-specific channel activity	0.261869836686301	bayes_pls_golite062009
myosin binding	0.259936573810332	bayes_pls_golite062009
ion channel activity	0.241519346930618	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
insulin receptor activity	0.237134032032089	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.20643152368029	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.20643152368029	bayes_pls_golite062009
peptide binding	0.118578378753757	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
actin-dependent ATPase activity	0.0339299940546054	bayes_pls_golite062009
MAP kinase kinase kinase kinase activity	0.01826424351081	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [520-607]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRPPFVPDLN SEIDAGYFDD FTNENDMSKY KEVHEKQAAI ANMVNTFNKP KRNAFIGFTF  60
   61 RHQKNSHPTS SSSALSSPLS APSFGTLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.09691
Match:	2esmA
Description:	Crystal Structure of ROCK 1 bound to fasudil
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: