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View Structure Prediction Details

Protein: CG1718-PA
Organism: Drosophila melanogaster
Length: 1713 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG1718-PA.

Description E-value Query
Range
Subject
Range
gi|114660456 - gi|114660456|ref|XP_510744.2| PREDICTED: ATP-binding cassette, sub-family A member 3 isoform 2 [Pan ...
1342.0 [0..4] [1713..1]

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Predicted Domain #1
Region A:
Residues: [1-186]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKVTNWDKF VLLLWKNWTL QWNHKWQMVI ELVLPAIFSL LLVLVRTLVD TEQKGVRYYN  60
   61 EQNLTDLNLL QKNGGFSKFE FILCYSPVNP VLKKLVEEAW QSLGKNKICE SENATQLELD 120
  121 TVSKNAFAGV QFDDAWANLT ENDPLPNDFH FALRFPAELR TATIAIANTW LTMRLFPTID 180
  181 LTGPRN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [187-385]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGDDDGGIPP GYLREGFLPL QHSLSMAYLR QKSGEQDLPN VVMKRYPFPA YIFDPLLEGM  60
   61 SSIMSLIILL SFIYPCTYIT KYITAEKEKQ LKEVMKIMGL SNWLHWTAWF VKSFIMLTIS 120
  121 AILIAILVKI NWSEDVAVLT HANFTALVFF LIIYIVSSIC FCFMMATFFS RASTAAAVTG 180
  181 LIWFIAYIPY SFTINSYDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [386-737]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSLSSKLGWS LISNTAMGFG IKLILGFEGT GEGLQWSNFF TPVSVDDTLT LGAVMIMMLV  60
   61 SCVIYMIICL YVEQVMPGSF GVPRPWNFPF TREFWCGERE YTGVEDIPNG HVEQRDPKAF 120
  121 ETEPEGKHIG LQMRHLKKRF GNKMVVKGLS MNMFEDEITV LLGHNGAGKT TTISMLTGMF 180
  181 PPTSGTAIIN GSDIRTNIEG ARMSLGICPQ HNVLFDEMSV SNHIRFFSRM KGLRGKAVEQ 240
  241 EVAKYLKMIE LEDKANVASS KLSGGMKRKL SVCCALCGDT KVVLCDEPSS GMDPSARRQL 300
  301 WDLLQQEKVG RTLLLTTHFM DEADVLGDRI AIMCDGELKC QGTSFFLKKQ YG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 1yqtA
Description: RNase-L Inhibitor
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [738-865]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGYRLVSGVQ NLFYGRCTYK TCDSLKICVK RDDCETNEVT ALLNKYIPGL KPECDIGAEL  60
   61 SYQLPDSASA KFEEMFGQLE EQSDELHLNG YGVGITSMEE VFMKVGAEKD NTGNIKDQHE 120
  121 IMNGGSGF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 84.69897
Match: 1q1bA
Description: Crystal structure of E. coli MalK in the nucleotide-free form
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [866-949]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGEDDNESVQ SDGIFSENRR LLQGLQLLSN QWKAMLLKKF LYTWRNKLLL LIQNIMPVFF  60
   61 VVVTILIIKT QGTFQELKPI TISL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [950-1035]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQYPLAVTVL DRSNVQNGTG YEIANKYEDL ARSYGSNYGL ELTGTQGFED YILDLGKTIQ  60
   61 VRINSRYLVA ATITESKITA WLNNQA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1036-1161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHTAPLTVNM VHNAIADKLF GSSVKIQVTN APLPYTTSTL LSQLSTGNNL GTQLASNLCF  60
   61 CMCFVSSIYI LFLIKERESR AKLLQFVGGV KVWTFWLSQF ICDFASYIVT ALIVVITIVC 120
  121 FQETGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1162-1366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STFGELGRYY LLLLLFGFAV LPFIYIMSLF FREPATGFAR VSIVNIFCGM ALFIVVVVMS  60
   61 SELFDTKDTA DILGWIFRIF PHFSLAMSLN KVYTNTATRN ACAKAGALPP ILLCELVPQC 120
  121 CNLKPYFAWE EPGVLPETVY MAVTGVVFFL IIIVLEFRLI NELMFKIRQL ISKPPPPPTE 180
  181 GQLDDDVANE RERILQMSSN ELATK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1367-1600]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLVLDRVTKY YGQFMAVNQV SLCVQEVECF GLLGVNGAGK TTTFKMMTGD ERISSGAAYV  60
   61 QGLSLESNMN SIYKMIGYCP QFDALLDDLT GREVLRIFCM LRGVQESRIR QLSEDLAKSF 120
  121 GFMKHIDKQT HAYSGGNKRK LSTAIAVIGS PSVIYLDEPT TGMDPAARRQ LWNMVCRIRD 180
  181 SGKSIVLTSH SMEECEALCT RLAIMVNGEF KCIGSTQHLK NKFSKGLILK IKVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.69897
Match: 1vplA
Description: Crystal structure of ABC transporter ATP-binding protein (TM0544) from Thermotoga maritima at 2.10 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity 6.58863529263644 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 6.58067278719409 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 6.57974651657836 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 6.57922174989907 bayes_pls_golite062009
primary active transmembrane transporter activity 6.57807080367604 bayes_pls_golite062009
nucleoside-triphosphatase activity 6.48406410175216 bayes_pls_golite062009
active transmembrane transporter activity 6.48154954364331 bayes_pls_golite062009
pyrophosphatase activity 6.40467109535527 bayes_pls_golite062009
ATPase activity, coupled 6.40151534181487 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 6.38373914253885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.38247436082206 bayes_pls_golite062009
ATPase activity 6.30019941712404 bayes_pls_golite062009
peptide transporter activity 4.7442815698413 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 4.71935767060308 bayes_pls_golite062009
peptide-transporting ATPase activity 4.63590351019108 bayes_pls_golite062009
hydrolase activity 4.60957912556603 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 4.35344629015015 bayes_pls_golite062009
oligopeptide-transporting ATPase activity 4.09365342567844 bayes_pls_golite062009
ribonucleotide binding 3.79710854336074 bayes_pls_golite062009
purine ribonucleotide binding 3.7956093726294 bayes_pls_golite062009
ATP binding 3.78352939926331 bayes_pls_golite062009
purine nucleotide binding 3.74676466237472 bayes_pls_golite062009
adenyl ribonucleotide binding 3.73153142187361 bayes_pls_golite062009
nucleotide binding 3.71970404557651 bayes_pls_golite062009
adenyl nucleotide binding 3.66815111788068 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity 3.20894563245332 bayes_pls_golite062009
phosphate transmembrane transporter activity 3.14373643903738 bayes_pls_golite062009
anion transmembrane transporter activity 3.13913638619234 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.9271291809464 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.63419811368692 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
binding 2.0681607836408 bayes_pls_golite062009
oligopeptide transporter activity 2.05580564974083 bayes_pls_golite062009
molybdate ion transmembrane transporter activity 2.04724145339382 bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity 2.04724145339382 bayes_pls_golite062009
lipopolysaccharide transmembrane transporter activity 1.92426772294655 bayes_pls_golite062009
lipopolysaccharide-transporting ATPase activity 1.92426772294655 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
polysaccharide transmembrane transporter activity 1.87680514870933 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
organic anion transmembrane transporter activity 1.76999970080179 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
sugar transmembrane transporter activity 1.57734504779864 bayes_pls_golite062009
phosphonate transmembrane transporter activity 1.40269234722336 bayes_pls_golite062009
carbohydrate-transporting ATPase activity 1.37859980472197 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
carbohydrate-importing ATPase activity 1.27327946933978 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
potassium channel activity 1.20877745413881 bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity 1.1220946941463 bayes_pls_golite062009
dipeptide transporter activity 1.01130176523309 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
signal transducer activity 0.952448314982579 bayes_pls_golite062009
molecular transducer activity 0.952448314982579 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
copper ion transmembrane transporter activity 0.798934081014025 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
vitamin transporter activity 0.492482773015923 bayes_pls_golite062009
L-aspartate transmembrane transporter activity 0.483217496906356 bayes_pls_golite062009
DNA-dependent ATPase activity 0.43042801294444 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
glucoside transmembrane transporter activity 0.31429820040527 bayes_pls_golite062009
maltose transmembrane transporter activity 0.309333293394255 bayes_pls_golite062009
alpha-glucoside transmembrane transporter activity 0.309333293394255 bayes_pls_golite062009
disaccharide transmembrane transporter activity 0.309333293394255 bayes_pls_golite062009
oligosaccharide transmembrane transporter activity 0.304521826432814 bayes_pls_golite062009
oligosaccharide-transporting ATPase activity 0.304521826432814 bayes_pls_golite062009
maltose-transporting ATPase activity 0.304521826432814 bayes_pls_golite062009
kinase activity 0.300431561463583 bayes_pls_golite062009
signal recognition particle binding 0.29390189699022 bayes_pls_golite062009
receptor activity 0.277332279568238 bayes_pls_golite062009
transmembrane receptor activity 0.243026482777117 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
nucleic acid binding 0.223761285614869 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.219473333671469 bayes_pls_golite062009
cholesterol transporter activity 0.20165628585345 bayes_pls_golite062009
protein kinase activity 0.194459978373898 bayes_pls_golite062009
protein binding 0.193768631623192 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.0689844878028699 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009

Predicted Domain #10
Region A:
Residues: [1601-1713]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNLEALRQAR LSGGYARNPD EQTVPAQMSQ RDIDAVKEFV ETEYPNSILQ EEYQGILTFY  60
   61 IPLTGVKWSR IFGLMESNRD QLNVEDYSVS QTTLEEIFLE FAKYQREDTR ANQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.522879
Match: 2d62A
Description: No description for 2d62A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle