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View Structure Prediction Details

Protein: Hmt-1-PA
Organism: Drosophila melanogaster
Length: 866 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Hmt-1-PA.

Description E-value Query
Range		 Subject
Range
gi|54639005, gi|... - gi|54639005|gb|EAL28407.1| GA18045-PA [Drosophila pseudoobscura], gi|125776391|ref|XP_001359262.1| G...
 678.0 [0..1] [828..1]

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Predicted Domain #1
Region A:
Residues: [1-226] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYCPPNVTL SEVWTQHGIS HCFMDTVGPA VYGGFLLLFG SIQLLMYRKY ATRITDPTQI  60
   61 SKSRLFAMQL FLLLLLPVLA LLRFLMNARI YPDSAVYGYM IFSTCVVCFS YPFSICLILK 120
  121 ERYYQLPSMP TRGHGLVLLL FWTLAFINES LAFINLRHED WWFHLKTNKD QIEMGLFVTR 180
  181 FLCSLLIFVL GLKAPGIMAP YNPHQRLDND TANESQGNVQ TGSAFR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [227-800] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGWRKLRTVF PYLWPKKNIA LQIAVIVCII LLLAGRVIKL FLPIYRKKLV DSLTIAPIVF  60
   61 RWDFVLIYVA LSFLQGGGTG SMGLFNNLRT FLWIRVQQYT TREIEIELFR HLHQLSLRWH 120
  121 LQRKTGEVLR VMDRGTDSIN NLLNYIVFSI APTILDLLVA VAYFVYAFNW WFGLIVFLTM 180
  181 FLYIASTIAI TEWRTKYQRR MNLADNEQRA RSVDSLLNFE TVKYYGAEHY EVDCYREAIL 240
  241 KYQKEEFLSM LTLNMLNTAQ NIILCLGLLA GSLLCVYLVV HHQTLTVGDF VLFSTYLMEL 300
  301 YMPLNWFGTY YRAIQKNFVD MENMFDLLKE EEEIVDAPGC SPLLTAGGGI EFSNVTFGYS 360
  361 PEKIVLRNVS FTVPAGKTVA IVGPSGAGKS TIMRLLFRFY DVQTGAILID GQNIKLVQQQ 420
  421 SLRKAIGVVP QDTVLFNNTI FYNIEYAKLG ASDEAVYEAA RAADIHERIL GFPEKYETKV 480
  481 GERGLRLSGG EKQRVAIART LLKAPIIVLL DEATSALDTH TERNIQAALA RVCANRTTII 540
  541 VAHRLSTIIH ADEILVLQQG SIAERGRHEE LVLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 149.0
Match: 2hydA
Description: No description for 2hydA was found.

Predicted functions:

Term Confidence Notes
lipid transporter activity 7.47642599298853 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 5.57844095962502 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.57813579764186 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.57813579764186 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.5689620139321 bayes_pls_golite062009
primary active transmembrane transporter activity 5.55992639965745 bayes_pls_golite062009
active transmembrane transporter activity 5.50005167063544 bayes_pls_golite062009
ATPase activity, coupled 4.98276715440477 bayes_pls_golite062009
heme transporter activity 4.82479229680991 bayes_pls_golite062009
peptide transporter activity 4.7442815698413 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 4.71935767060308 bayes_pls_golite062009
ATPase activity 4.69795387297193 bayes_pls_golite062009
peptide-transporting ATPase activity 4.63590351019108 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.45923622153365 bayes_pls_golite062009
pyrophosphatase activity 4.39781350157199 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.38133275795019 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.38085303582726 bayes_pls_golite062009
cofactor transporter activity 4.34709589308604 bayes_pls_golite062009
oligopeptide-transporting ATPase activity 4.09365342567844 bayes_pls_golite062009
transporter activity 3.71239480053329 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity 3.20894563245332 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.19399273923292 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 3.16975154423199 bayes_pls_golite062009
hydrolase activity 3.14498892233323 bayes_pls_golite062009
transmembrane transporter activity 3.13960906549884 bayes_pls_golite062009
anion transmembrane transporter activity 3.13913638619234 bayes_pls_golite062009
substrate-specific transporter activity 3.1318898376276 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
ATP binding 3.01346604299372 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.00745742755195 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
adenyl ribonucleotide binding 2.96271391116269 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.9271291809464 bayes_pls_golite062009
adenyl nucleotide binding 2.91131545957759 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
purine ribonucleotide binding 2.70262534541085 bayes_pls_golite062009
ribonucleotide binding 2.70178191749524 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
purine nucleotide binding 2.6583477492092 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.63419811368692 bayes_pls_golite062009
nucleotide binding 2.62374702628143 bayes_pls_golite062009
sterol transporter activity 2.48473697371886 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
phosphate transmembrane transporter activity 2.15147988861177 bayes_pls_golite062009
oligopeptide transporter activity 2.05580564974083 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
organic anion transmembrane transporter activity 1.76999970080179 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
binding 1.64266915208623 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
phosphonate transmembrane transporter activity 1.40269234722336 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
molybdate ion transmembrane transporter activity 1.28313088935613 bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity 1.28313088935613 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
potassium channel activity 1.20877745413881 bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity 1.1220946941463 bayes_pls_golite062009
dipeptide transporter activity 1.01130176523309 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
RNA helicase activity 0.94708387424268 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.93133090558732 bayes_pls_golite062009
RNA-dependent ATPase activity 0.91827876091109 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
copper ion transmembrane transporter activity 0.798934081014025 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
helicase activity 0.73689027003638 bayes_pls_golite062009
ATP-dependent helicase activity 0.72833102894594 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.72833102894594 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
cholesterol transporter activity 0.644421039250979 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
DNA-dependent ATPase activity 0.62832939629645 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
vitamin transporter activity 0.477646469354653 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
catalytic activity 0.368034275052766 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.219473333671469 bayes_pls_golite062009
signal recognition particle binding 0.20866768220789 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
nucleic acid binding 0.144904409289829 bayes_pls_golite062009
sulfate transmembrane transporter activity 0.104477131120205 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
signal transducer activity 0.070999348597689 bayes_pls_golite062009
molecular transducer activity 0.070999348597689 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
structure-specific DNA binding 0.050232896280066 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [801-866] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDGIYADMWQ QQLKNLDAEQ SGGSDNGDAS AESGSEKRRA GGAGGPSGTG TGGAHFRAGH  60
   61 AHGGAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.0
Match: 1z47A
Description: Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle