YRC Public Data Repository - Protein Structure Prediction

Protein:	PDR18
Organism:	Saccharomyces cerevisiae
Length:	1333 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDR18.

Description	E-value	Query Range	Subject Range
gi\|18152891 - gi\|18152891\|gb\|AAK62810.2\|AF227914_1 ATP-binding cassette transporter ABC1 [Venturia inaequalis]	0.0	[2..1333]	[163..1482]
CDR4_CANAX - ABC transporter CDR4 OS=Candida albicans GN=CDR4 PE=3 SV=1	0.0	[3..1332]	[130..1457]
gi\|445052, gi\|295839 - gi\|445052\|prf\|\|1908372A SNQ2 gene, gi\|295839\|emb\|CAA47270.1\| 169 kDa protein [Saccharomyces cerevisi...	0.0	[1..1332]	[132..1457]
gi\|66826585, gi\|... - gi\|66826585\|ref\|XP_646647.1\| ABC transporter G family protein [Dictyostelium discoideum AX4], gi\|604... ABCGJ_DICDI - ABC transporter G family member 19 OS=Dictyostelium discoideum GN=abcG19 PE=3 SV=1	0.0	[1..1333]	[107..1426]
gi\|6175524 - gi\|6175524\|gb\|AAF05069.1\|AF109723_1 ATP-binding cassette transporter [Candida glabrata]	0.0	[3..1332]	[119..1468]
gi\|14278974 - gi\|14278974\|dbj\|BAB59028.1\| ABC transporter PMR5 [Penicillium digitatum]	0.0	[2..1333]	[71..1388]
BFR1_SCHPO - Brefeldin A resistance protein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=bfr1 PE=1 S... bfr1 - brefeldin A efflux transporter Bfr1	0.0	[1..1332]	[137..1493]

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Predicted Domain #1

Region A:
Residues: [1-308]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MECVSVEGLD SSFLEGQTFG DILCLPWTII KGIRERKNRN KMKIILKNVS LLAKSGEMVL  60
   61 VLGRPGAGCT SFLKSAAGET SQFAGGVTTG HISYDGIPQK EMMQHYKPDV IYNGEQDVHF 120
  121 PHLTVKQTLD FAISCKMPAK RVNNVTKEEY ITANREFYAK IFGLTHTFDT KVGNDFISGV 180
  181 SGGERKRVSI AEALAAKGSI YCWDNATRGL DSSTALEFAR AIRTMTNLLG TTALVTVYQA 240
  241 SENIYETFDK VTVLYAGRQI FCGKTTEAKD YFENMGYLCP PRQSTAEYLT AITDPNGLHE 300
  301 IKPGFEYQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	124.045757
Match:	1jj7A_
Description:	Peptide transporter Tap1, C-terminal ABC domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [309-367]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPHTADEFEK YWLDSPEYAR LKGEIQKYKH EVNTEWTKKT YNESMAQEKS KGTRKKSYY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.813	a.44.1	Disulphide-bond formation facilitator (DSBA), insertion domain

Predicted Domain #3

Region A:
Residues: [368-481]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVSYWEQIRL CTIRGFLRIY GDKSYTVINT CAAIAQAFIT GSLFYQAPSS TLGAFSRSGV  60
   61 LFFSLLYYSL MGLANISFEH RPILQKHKVY SLYHPSAEAL ASTISSFPFR MIGL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [523-710]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLCDTLSQA NSIAGVVMLS IAMYSTYMIQ LPSMHPWFKW ISYILPIRYA FESMLNAEFH  60
   61 GRHMDCGGTL VPSGPGFENI LPENQVCAFV GSRPGQSWVL GDDYLRAQYQ YEYKNTWRNF 120
  121 GIMWCFLIGY IVLRAVFTEY KSPVKSGGDA LVVKKGTKNA IQRSWSSKND EENLNASIAT 180
  181 QDMKEIAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	169.616428
Match:	1jsqA_
Description:	MsbA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
lipid transporter activity	7.47642599298853	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	5.57844095962502	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	5.57813579764186	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	5.57813579764186	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	5.5689620139321	bayes_pls_golite062009
primary active transmembrane transporter activity	5.55992639965745	bayes_pls_golite062009
active transmembrane transporter activity	5.50005167063544	bayes_pls_golite062009
ATPase activity, coupled	4.98276715440477	bayes_pls_golite062009
ATPase activity	4.69795387297193	bayes_pls_golite062009
nucleoside-triphosphatase activity	4.45923622153365	bayes_pls_golite062009
sterol transporter activity	4.45355165759136	bayes_pls_golite062009
pyrophosphatase activity	4.39781350157199	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	4.38133275795019	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4.38085303582726	bayes_pls_golite062009
transporter activity	3.71239480053329	bayes_pls_golite062009
hydrolase activity	3.67426835966263	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
transmembrane transporter activity	3.13960906549884	bayes_pls_golite062009
substrate-specific transporter activity	3.1318898376276	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
iron ion transmembrane transporter activity	3.05511942104215	bayes_pls_golite062009
ATP binding	3.01346604299372	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.00745742755195	bayes_pls_golite062009
drug transmembrane transporter activity	2.97119034312001	bayes_pls_golite062009
adenyl ribonucleotide binding	2.96271391116269	bayes_pls_golite062009
adenyl nucleotide binding	2.91131545957759	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	2.88795687640992	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.88476360771975	bayes_pls_golite062009
cholesterol transporter activity	2.72457626066894	bayes_pls_golite062009
purine ribonucleotide binding	2.70262534541085	bayes_pls_golite062009
ribonucleotide binding	2.70178191749524	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
purine nucleotide binding	2.6583477492092	bayes_pls_golite062009
nucleotide binding	2.62374702628143	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.61311581579476	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
	2.20174656498665	bayes_pls_golite062009
apolipoprotein receptor activity	2.15656963765495	bayes_pls_golite062009
syntaxin-13 binding	2.15656963765495	bayes_pls_golite062009
apolipoprotein A-I binding	2.15656963765495	bayes_pls_golite062009
apolipoprotein A-I receptor activity	2.15656963765495	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	2.12727614888121	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	1.95782378818812	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	1.88153949603611	bayes_pls_golite062009
binding	1.84115074893083	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
azole transporter activity	1.75428613304237	bayes_pls_golite062009
fluconazole transporter activity	1.75428613304237	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
nucleic acid binding	1.62884148289979	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.58971273330352	bayes_pls_golite062009
DNA binding	1.53176391519962	bayes_pls_golite062009
transcription regulator activity	1.49517431175162	bayes_pls_golite062009
signal recognition particle binding	1.46975774710831	bayes_pls_golite062009
peptide-transporting ATPase activity	1.37783759788533	bayes_pls_golite062009
cation channel activity	1.33585529285301	bayes_pls_golite062009
sterol-transporting ATPase activity	1.30536878174919	bayes_pls_golite062009
glycoprotein transporter activity	1.30536878174919	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
peptide transporter activity	1.19353064661766	bayes_pls_golite062009
potassium channel activity	1.17288958041707	bayes_pls_golite062009
voltage-gated cation channel activity	1.00384984515681	bayes_pls_golite062009
voltage-gated ion channel activity	0.889208591820696	bayes_pls_golite062009
motor activity	0.87979065815418	bayes_pls_golite062009
voltage-gated channel activity	0.871525745291603	bayes_pls_golite062009
	0.869999622006359	bayes_pls_golite062009
ion channel activity	0.848261056209476	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
channel activity	0.806331380134838	bayes_pls_golite062009
passive transmembrane transporter activity	0.806331380134838	bayes_pls_golite062009
substrate-specific channel activity	0.799997700906738	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
phospholipid transporter activity	0.755445322666929	bayes_pls_golite062009
gated channel activity	0.650050847753837	bayes_pls_golite062009
guanyl nucleotide binding	0.640772201693186	bayes_pls_golite062009
guanyl ribonucleotide binding	0.63468044350616	bayes_pls_golite062009
DNA-dependent ATPase activity	0.62832939629645	bayes_pls_golite062009
GTP binding	0.621689261700018	bayes_pls_golite062009
ribonucleoprotein binding	0.53788302029845	bayes_pls_golite062009
anion transmembrane transporter activity	0.43332053110728	bayes_pls_golite062009
catalytic activity	0.368034275052766	bayes_pls_golite062009
transcription factor activity	0.344643343870781	bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity	0.301752323171649	bayes_pls_golite062009
signal transducer activity	0.286367085584159	bayes_pls_golite062009
molecular transducer activity	0.286367085584159	bayes_pls_golite062009
G-protein coupled receptor activity	0.169034229773346	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
microtubule motor activity	0.11674780318211	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
structure-specific DNA binding	0.050232896280066	bayes_pls_golite062009
transcription activator activity	0.0291047953833683	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [482-522]

      1          11         21         31         41         51         
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    1 TFFIIILYFL AGLHRSAGAF FTMYLLLTMC SEAITSLFQM V

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [711-977]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNDDSTSADF EGLESTGVFI WKNVSFTIPH SSGQRKLLDS VSGYCVPGTL TALIGESGAG  60
   61 KTTLLNTLAQ RNVGTITGDM LVDGLPMDAS FKRRTGYVQQ QDLHVAELTV KESLQFSARM 120
  121 RRPQSIPDAE KMEYVEKIIS ILEMQEFSEA LVGEIGYGLN VEQRKKLSIG VELVGKPDLL 180
  181 LFLDEPTSGL DSQSAWAVVK MLKRLALAGQ SILCTIHQPS ATLFEQFDRL LLLGKGGQTI 240
  241 YFGEIGKNSS SVIKYFEKNG ARKCQQN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	169.616428
Match:	1jsqA_
Description:	MsbA
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [978-1273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENPAEYILEA IGAGATASVQ QNWPDIWQKS HEYANINEKI NDMIKDLSST TLHKTATRAS  60
   61 KYATSYSYQF HHVLKRSSLT FWRNLNYIMA KMMLLMISGL FIGFTFFHVG VNAIGLQNSL 120
  121 FACFMAIVIS APATNQIQER ATVAKELYEV RESKSNMFHW SLLLITHYLN ELPYHLLFST 180
  181 IFFVSSYFPL GVFTEASRSS VFYLNYAILF QLYYIGLALM ILYMSPNLQS ANVIVGFILS 240
  241 FLLSFCGAVQ PASLMPGFWT FMWKLSPYTY FLQNLVGLLM HDKPVRCSKK ELSLFN

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1274-1333]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPVGQTCGEF TKPFFEFGTG YIANPDATAD CAYCQYKVGD EYLARINASF SYLWRNFGFI  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: