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View Structure Prediction Details

Protein: RAS2
Organism: Saccharomyces cerevisiae
Length: 322 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RAS2.

Description E-value Query
Range		 Subject
Range
RAS2_YEAST - Ras-like protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAS2 PE=1 SV=4
gi|207341727 - gi|207341727|gb|EDZ69704.1| YNL098Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190409087 - gi|190409087|gb|EDV12352.1| small GTP-binding protein [Saccharomyces cerevisiae RM11-1a]
RAS2 - GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous gr...
gi|151944436 - gi|151944436|gb|EDN62714.1| small GTP-binding protein [Saccharomyces cerevisiae YJM789]
 0.0 [1..322] [1..322]
YPTC6_CHLRE - Ras-related protein YPTC6 OS=Chlamydomonas reinhardtii GN=YPTC6 PE=3 SV=1
 2.0E-90 [4..214] [6..216]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 3.0E-90 [3..211] [1..201]
ARA5_ARATH - Ras-related protein ARA-5 - Arabidopsis thaliana (Mouse-ear cress)
 5.0E-90 [3..211] [56..257]
YPT3_NICPL - Ras-related protein YPT3 OS=Nicotiana plumbaginifolia GN=YPT3 PE=2 SV=1
 2.0E-89 [3..215] [6..218]
gi|1370166 - gi|1370166|emb|CAA98160.1| RAB1C [Lotus japonicus]
 3.0E-89 [3..211] [1..201]
RB11A_PONAB - Ras-related protein Rab-11A OS=Pongo abelii GN=RAB11A PE=2 SV=3
CCDS10212.1_1 - null
ENSCJAT00000014411 - null
RB11A_RABIT - Ras-related protein Rab-11A OS=Oryctolagus cuniculus GN=RAB11A PE=2 SV=3
RB11A_RAT - Ras-related protein Rab-11A OS=Rattus norvegicus GN=Rab11a PE=1 SV=3
RB11A_PONPY - Ras-related protein Rab-11A - Pongo pygmaeus (Orangutan)
RB11A_MOUSE - Ras-related protein Rab-11A OS=Mus musculus GN=Rab11a PE=1 SV=3
RB11A_CANLF - Ras-related protein Rab-11A OS=Canis lupus familiaris GN=RAB11A PE=2 SV=3
ENSMMUG000000080... - null, null
gi|123999492, gi... - gi|61355514|gb|AAX41148.1| RAB11A member RAS oncogene family [synthetic construct], gi|61355506|gb|A...
gi|114657631 - gi|114657631|ref|XP_510490.2| PREDICTED: similar to rab11 [Pan troglodytes]
tr|G3I0B0|G3I0B0... - Ras-related protein Rab-11A OS=Cricetulus griseus GN=I79_016788 PE=3 SV=1
tr|M3WVD0|M3WVD0... - RAB11A, member RAS oncogene family OS=Felis catus GN=RAB11A PE=4 SV=1
gi|76675213|ref|... - PREDICTED: similar to RAB11a, member RAS oncogene family isoform 2 [Bos taurus], Isoform of Q2TA29, ...
RB11A_PIG - Ras-related protein Rab-11A OS=Sus scrofa GN=RAB11A PE=2 SV=3
gi|126277069 - gi|126277069|ref|XP_001367185.1| PREDICTED: similar to rab11 [Monodelphis domestica]
RAB11A - RAB11A, member RAS oncogene family
 3.0E-89 [4..215] [5..215]

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Predicted Domain #1
Region A:
Residues: [1-185] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLNKSNIRE YKLVVVGGGG VGKSALTIQL TQSHFVDEYD PTIEDSYRKQ VVIDDEVSIL  60
   61 DILDTAGQEE YSAMREQYMR NGEGFLLVYS ITSKSSLDEL MTYYQQILRV KDTDYVPIVV 120
  121 VGNKSDLENE KQVSYQDGLN MAKQMNAPFL ETSAKQAINV EEAFYTLARL VRDEGGKYNK 180
  181 TLTEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 609.0
Match: 821p__
Description: cH-p21 Ras protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 4.52394549632777 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
microtubule motor activity 3.91769993918004 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
microfilament motor activity 2.51786963027655 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
actin binding 2.2973522188675 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.26365379756656 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
tubulin binding 1.92557767696163 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
microtubule binding 1.84561785126784 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
G-protein coupled receptor activity 1.63949223587737 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
actin filament binding 1.28204719195916 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
nucleotide kinase activity 1.10251779925246 bayes_pls_golite062009
beta-catenin binding 1.03146778136145 bayes_pls_golite062009
apolipoprotein receptor activity 1.02132483910092 bayes_pls_golite062009
syntaxin-13 binding 1.02132483910092 bayes_pls_golite062009
apolipoprotein A-I binding 1.02132483910092 bayes_pls_golite062009
apolipoprotein A-I receptor activity 1.02132483910092 bayes_pls_golite062009
GDP-dissociation inhibitor binding 1.01467127484205 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
cation channel activity 0.997064416395892 bayes_pls_golite062009
GMP binding 0.975301479415235 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
actin-dependent ATPase activity 0.92105578610354 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
transferase activity 0.871779313294914 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
structural constituent of muscle 0.842950252373832 bayes_pls_golite062009
copper ion transmembrane transporter activity 0.816469301666725 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
voltage-gated cation channel activity 0.688632087597536 bayes_pls_golite062009
signal transducer activity 0.683309012097319 bayes_pls_golite062009
molecular transducer activity 0.683309012097319 bayes_pls_golite062009
transmembrane receptor activity 0.661834961742057 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
steroid hormone receptor binding 0.647625526012423 bayes_pls_golite062009
calcium channel activity 0.636216614902039 bayes_pls_golite062009
receptor activity 0.633514002718998 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.567883621045161 bayes_pls_golite062009
voltage-gated channel activity 0.562664200036023 bayes_pls_golite062009
voltage-gated ion channel activity 0.559798751382976 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
protein transporter activity 0.498432226280822 bayes_pls_golite062009
DNA strand annealing activity 0.495691434532349 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 0.40217318916177 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
hormone receptor binding 0.351501100511918 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
potassium channel activity 0.329290830676079 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.328170855722634 bayes_pls_golite062009
gated channel activity 0.299411774392227 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
nuclear hormone receptor binding 0.246160342138071 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
ion channel activity 0.154779598791225 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
channel activity 0.134817721656507 bayes_pls_golite062009
passive transmembrane transporter activity 0.134817721656507 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
substrate-specific channel activity 0.126911677161968 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
voltage-gated calcium channel activity 0.0789800146503108 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.0122470146764899 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [186-322] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNSKQTSQDT KGSGANSVPR NSGGHRKMSN AANGKNVNSS TTVVNARNAS IESKTGLAGN  60
   61 QATNGKTQTD RTNIDNSTGQ AGQANAQSAN TVNNRVNNNS KAGQVSNAKQ ARKQQAAPGG 120
  121 NTSEASKSGS GGCCIIS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle