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View Structure Prediction Details

Protein: GPA2
Organism: Saccharomyces cerevisiae
Length: 449 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPA2.

Description E-value Query
Range		 Subject
Range
gi|171615 - gi|171615|gb|AAA34651.1| nucleotide-binding regulatory protein GPA2
 0.0 [1..449] [1..449]
GNAI1_RAT - Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Rattus norvegicus GN=Gnai1 PE=1 SV=3
 0.0 [89..447] [2..353]
gi|5650709 - gi|5650709|emb|CAB43212.2| hypothetical protein [Homo sapiens]
gi|117646132 - gi|117646132|emb|CAL38533.1| hypothetical protein [synthetic construct]
 0.0 [89..447] [2..353]
GNAI1_CAVPO - Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Cavia porcellus GN=GNAI1 PE=2 SV=3
 0.0 [89..447] [2..353]
gi|147899005, gi... - gi|147899005|ref|NP_001090865.1| hypothetical protein LOC100038283 [Xenopus (Silurana) tropicalis], ...
GNAI1_XENLA - Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Xenopus laevis GN=gnai1 PE=2 SV=3
 0.0 [89..447] [2..353]
gi|2624611, gi|2... - gi|2624611|pdb|1AS2| Chain , Gdp+pi Bound G42v Gia1, gi|2624610|pdb|1AS0| Chain , Gtp-Gamma-S Bo...
gi|2624612 - gi|2624612|pdb|1AS3| Chain , Gdp Bound G42v Gia1
 0.0 [89..447] [1..352]

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Predicted Domain #1
Region A:
Residues: [1-67] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLCASSEKN GSTPDTQTAS AGSDNVGKAK VPPKQEPQKT VRTVNTANQQ EKQQQRQQQP  60
   61 SPHNVKD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [68-150] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKEQNGSINN AISPTATANT SGSQQINIDS ALRDRSSNVA AQPSLSDASS GSNDKELKVL  60
   61 LLGAGESGKS TVLQQLKILH QNG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [274-449] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMTSGIFDTV IDMGSDIKMH IYDVGGQRSE RKKWIHCFDN VTLVIFCVSL SEYDQTLMED  60
   61 KNQNRFQESL VLFDNIVNSR WFARTSVVLF LNKIDLFAEK LSKVPMENYF PDYTGGSDIN 120
  121 KAAKYILWRF VQLNRANLSI YPHVTQATDT SNIRLVFAAI KETILENTLK DSGVLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 954.0
Match: 1agrA_
Description: Transducin (alpha subunit), insertion domain; Transducin (alpha subunit)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 5.72147024962513 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
D5 dopamine receptor binding 3.08570478913368 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
opioid receptor binding 3.0590320138875 bayes_pls_golite062009
mu-type opioid receptor binding 3.0590320138875 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.9271291809464 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
actin binding 2.84620358490972 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.84244354516172 bayes_pls_golite062009
cytoskeletal protein binding 2.66896300219871 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 2.66230364606923 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.63419811368692 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
voltage-gated cation channel activity 2.53108219315762 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
potassium channel activity 2.46310745048836 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
voltage-gated ion channel activity 2.41620811021426 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
voltage-gated channel activity 2.39851043074742 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
motor activity 2.32425703346903 bayes_pls_golite062009
G-protein coupled receptor activity 2.30817043041689 bayes_pls_golite062009
microtubule motor activity 2.26003723459523 bayes_pls_golite062009
actin filament binding 2.1683792904715 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
G-protein-coupled receptor binding 2.06898720161422 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 1.39287418273886 bayes_pls_golite062009
protein transporter activity 1.39215697820305 bayes_pls_golite062009
cation channel activity 1.29420225212107 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
copper ion transmembrane transporter activity 1.23706764781183 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
transmembrane receptor activity 1.21184817199887 bayes_pls_golite062009
receptor activity 1.16341606083763 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
signal transducer activity 1.09878505418874 bayes_pls_golite062009
molecular transducer activity 1.09878505418874 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
transferase activity 0.871779313294914 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
ion channel activity 0.806272726391186 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
channel activity 0.763763253654647 bayes_pls_golite062009
passive transmembrane transporter activity 0.763763253654647 bayes_pls_golite062009
substrate-specific channel activity 0.757574988482518 bayes_pls_golite062009
microfilament motor activity 0.723407201613229 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.69784475011795 bayes_pls_golite062009
photoreceptor activity 0.686732297672157 bayes_pls_golite062009
calcium channel activity 0.636216614902039 bayes_pls_golite062009
structure-specific DNA binding 0.620212706423176 bayes_pls_golite062009
helicase activity 0.6191010101321 bayes_pls_golite062009
cell surface binding 0.618263399939881 bayes_pls_golite062009
gated channel activity 0.608454011116117 bayes_pls_golite062009
G-protein coupled photoreceptor activity 0.589388714632669 bayes_pls_golite062009
sterol transporter activity 0.57614280790431 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 0.563503770238611 bayes_pls_golite062009
double-stranded DNA binding 0.49000746592281 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
tubulin binding 0.326239364039846 bayes_pls_golite062009
oxidoreductase activity 0.311483600813201 bayes_pls_golite062009
ATP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
peptide binding 0.277339057010008 bayes_pls_golite062009
DNA strand annealing activity 0.270268254152179 bayes_pls_golite062009
microtubule binding 0.225323885896927 bayes_pls_golite062009
voltage-gated calcium channel activity 0.222632551268441 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.219473333671469 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
metabotropic serotonin receptor binding 0.178039386254807 bayes_pls_golite062009
protein transmembrane transporter activity 0.16843768852312 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
inositol hexakisphosphate binding 0.0574403090687272 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
signal recognition particle binding 0.00643331355694032 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [151-273] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSEQEIKEYI PLIYQNLLEI GRNLIQARTR FNVNLEPECE LTQQDLSRTM SYEMPNNYTG  60
   61 QFPEDIAGVI STLWALPSTQ DLVNGPNASK FYLMDSTPYF MENFTRITSP NYRPTQQDIL 120
  121 RSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 954.0
Match: 1agrA_
Description: Transducin (alpha subunit), insertion domain; Transducin (alpha subunit)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle