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View Structure Prediction Details

Protein: GPA2
Organism: Saccharomyces cerevisiae
Length: 449 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPA2.

Description E-value Query
Range		 Subject
Range
gi|171615 - gi|171615|gb|AAA34651.1| nucleotide-binding regulatory protein GPA2
 0.0 [1..449] [1..449]
GNAI1_RAT - Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Rattus norvegicus GN=Gnai1 PE=1 SV=3
 0.0 [89..447] [2..353]
gi|5650709 - gi|5650709|emb|CAB43212.2| hypothetical protein [Homo sapiens]
gi|117646132 - gi|117646132|emb|CAL38533.1| hypothetical protein [synthetic construct]
 0.0 [89..447] [2..353]
GNAI1_CAVPO - Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Cavia porcellus GN=GNAI1 PE=2 SV=3
 0.0 [89..447] [2..353]
gi|147899005, gi... - gi|147899005|ref|NP_001090865.1| hypothetical protein LOC100038283 [Xenopus (Silurana) tropicalis], ...
GNAI1_XENLA - Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Xenopus laevis GN=gnai1 PE=2 SV=3
 0.0 [89..447] [2..353]
gi|2624611, gi|2... - gi|2624611|pdb|1AS2| Chain , Gdp+pi Bound G42v Gia1, gi|2624610|pdb|1AS0| Chain , Gtp-Gamma-S Bo...
gi|2624612 - gi|2624612|pdb|1AS3| Chain , Gdp Bound G42v Gia1
 0.0 [89..447] [1..352]

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Predicted Domain #1
Region A:
Residues: [1-67] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLCASSEKN GSTPDTQTAS AGSDNVGKAK VPPKQEPQKT VRTVNTANQQ EKQQQRQQQP  60
   61 SPHNVKD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.259 a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.234 a.64.1 Saposin
View Download 0.215 d.70.1 Yest killer toxins
View Download 0.202 a.24.15 FAD-dependent thiol oxidase

Predicted Domain #2
Region A:
Residues: [68-150] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKEQNGSINN AISPTATANT SGSQQINIDS ALRDRSSNVA AQPSLSDASS GSNDKELKVL  60
   61 LLGAGESGKS TVLQQLKILH QNG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [274-449] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMTSGIFDTV IDMGSDIKMH IYDVGGQRSE RKKWIHCFDN VTLVIFCVSL SEYDQTLMED  60
   61 KNQNRFQESL VLFDNIVNSR WFARTSVVLF LNKIDLFAEK LSKVPMENYF PDYTGGSDIN 120
  121 KAAKYILWRF VQLNRANLSI YPHVTQATDT SNIRLVFAAI KETILENTLK DSGVLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 954.0
Match: 1agrA_
Description: Transducin (alpha subunit), insertion domain; Transducin (alpha subunit)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 5.72147024962513 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
D5 dopamine receptor binding 3.08570478913368 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
opioid receptor binding 3.0590320138875 bayes_pls_golite062009
mu-type opioid receptor binding 3.0590320138875 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.9271291809464 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
actin binding 2.84620358490972 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.84244354516172 bayes_pls_golite062009
cytoskeletal protein binding 2.66896300219871 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 2.66230364606923 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.63419811368692 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
voltage-gated cation channel activity 2.53108219315762 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
potassium channel activity 2.46310745048836 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
voltage-gated ion channel activity 2.41620811021426 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
voltage-gated channel activity 2.39851043074742 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
motor activity 2.32425703346903 bayes_pls_golite062009
G-protein coupled receptor activity 2.30817043041689 bayes_pls_golite062009
microtubule motor activity 2.26003723459523 bayes_pls_golite062009
actin filament binding 2.1683792904715 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
G-protein-coupled receptor binding 2.06898720161422 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 1.39287418273886 bayes_pls_golite062009
protein transporter activity 1.39215697820305 bayes_pls_golite062009
cation channel activity 1.29420225212107 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
copper ion transmembrane transporter activity 1.23706764781183 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
transmembrane receptor activity 1.21184817199887 bayes_pls_golite062009
receptor activity 1.16341606083763 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
signal transducer activity 1.09878505418874 bayes_pls_golite062009
molecular transducer activity 1.09878505418874 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
transferase activity 0.871779313294914 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
ion channel activity 0.806272726391186 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
channel activity 0.763763253654647 bayes_pls_golite062009
passive transmembrane transporter activity 0.763763253654647 bayes_pls_golite062009
substrate-specific channel activity 0.757574988482518 bayes_pls_golite062009
microfilament motor activity 0.723407201613229 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.69784475011795 bayes_pls_golite062009
photoreceptor activity 0.686732297672157 bayes_pls_golite062009
calcium channel activity 0.636216614902039 bayes_pls_golite062009
structure-specific DNA binding 0.620212706423176 bayes_pls_golite062009
helicase activity 0.6191010101321 bayes_pls_golite062009
cell surface binding 0.618263399939881 bayes_pls_golite062009
gated channel activity 0.608454011116117 bayes_pls_golite062009
G-protein coupled photoreceptor activity 0.589388714632669 bayes_pls_golite062009
sterol transporter activity 0.57614280790431 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 0.563503770238611 bayes_pls_golite062009
double-stranded DNA binding 0.49000746592281 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
tubulin binding 0.326239364039846 bayes_pls_golite062009
oxidoreductase activity 0.311483600813201 bayes_pls_golite062009
ATP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
peptide binding 0.277339057010008 bayes_pls_golite062009
DNA strand annealing activity 0.270268254152179 bayes_pls_golite062009
microtubule binding 0.225323885896927 bayes_pls_golite062009
voltage-gated calcium channel activity 0.222632551268441 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.219473333671469 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
metabotropic serotonin receptor binding 0.178039386254807 bayes_pls_golite062009
protein transmembrane transporter activity 0.16843768852312 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
inositol hexakisphosphate binding 0.0574403090687272 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
signal recognition particle binding 0.00643331355694032 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [151-273] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSEQEIKEYI PLIYQNLLEI GRNLIQARTR FNVNLEPECE LTQQDLSRTM SYEMPNNYTG  60
   61 QFPEDIAGVI STLWALPSTQ DLVNGPNASK FYLMDSTPYF MENFTRITSP NYRPTQQDIL 120
  121 RSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 954.0
Match: 1agrA_
Description: Transducin (alpha subunit), insertion domain; Transducin (alpha subunit)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle