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View Structure Prediction Details

Protein: MIRO2_ARATH
Organism: Arabidopsis thaliana
Length: 643 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MIRO2_ARATH.

Description E-value Query
Range		 Subject
Range
MIRO1_MOUSE - Mitochondrial Rho GTPase 1 OS=Mus musculus GN=Rhot1 PE=1 SV=1
 641.0 [0..9] [637..12]

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Predicted Domain #1
Region A:
Residues: [1-209] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLGGKSSAG GRTSLRVAVA GDKGTGKSSL ISAVASETFP DNVPRVLPPI TLPADAFPDY  60
   61 IPITIVDTPS SIDNRIKLIE EFRKADVVLL TYACDQPSTL DRLSSYWLPE LRRLEIKAPV 120
  121 IVVGCKLDLR DERSPARLED IMSPIMKEYR EIETCIECSA LTLIQVPDVF YFASKAVLHP 180
  181 TFPLFDQEKQ CLKPRLRRAV QRIFNLCDH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.522879
Match: 2j0vA
Description: No description for 2j0vA was found.

Predicted Domain #2
Region A:
Residues: [210-419] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLDGALNDAE LNDFQVNCFG APLDPVELMG VKKVVQERQP DGVTDLGLTL PGFLFLFSLF  60
   61 IERGRPETAW AILRKCGYND SLELHAELLP VPAKQSPDQS IELTNEAMDF LSGIFQLYDL 120
  121 DNDGALQPAE LDDLFQTAPD SPWLEDPYKE AAEKTPGGSL TINGFLSEWA LMTLLDPRKS 180
  181 LANLTYIGYG HDPASTFSVT RKRSVDRKKQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.75
Match: 1s6iA
Description: Ca2+-regulatory region (CLD) from soybean calcium-dependent protein kinase-alpha (CDPK) in the presence of Ca2+ and the junction domain (JD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microfilament motor activity 4.45303978391319 bayes_pls_golite062009
structural constituent of muscle 4.17425727569631 bayes_pls_golite062009
actin binding 3.88684829626445 bayes_pls_golite062009
N-terminal myristoylation domain binding 3.80339533401898 bayes_pls_golite062009
actin-dependent ATPase activity 3.711916874543 bayes_pls_golite062009
cytoskeletal protein binding 3.37000471863591 bayes_pls_golite062009
motor activity 3.1249083077713 bayes_pls_golite062009
binding 3.05873877511752 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.62465453278501 bayes_pls_golite062009
ion transmembrane transporter activity 2.58331384033974 bayes_pls_golite062009
cation transmembrane transporter activity 2.56450760908401 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.39219065596758 bayes_pls_golite062009
actin filament binding 2.30048067867865 bayes_pls_golite062009
transcription regulator activity 2.24902417974535 bayes_pls_golite062009
protein binding 2.14478474415587 bayes_pls_golite062009
myosin binding 2.10411787927632 bayes_pls_golite062009
structural molecule activity 1.98487959981447 bayes_pls_golite062009
nucleic acid binding 1.87696818526628 bayes_pls_golite062009
cation binding 1.78612329591962 bayes_pls_golite062009
metal ion binding 1.78612329591962 bayes_pls_golite062009
ion binding 1.7794276789734 bayes_pls_golite062009
DNA binding 1.76986399532013 bayes_pls_golite062009
tubulin binding 1.72103324458698 bayes_pls_golite062009
molecular transducer activity 1.57685201816793 bayes_pls_golite062009
signal transducer activity 1.57685201816793 bayes_pls_golite062009
cation channel activity 1.4950665324992 bayes_pls_golite062009
microtubule binding 1.40304801620622 bayes_pls_golite062009
transporter activity 1.18173318787461 bayes_pls_golite062009
channel activity 1.06257290148275 bayes_pls_golite062009
passive transmembrane transporter activity 1.06257290148275 bayes_pls_golite062009
ion channel activity 1.04002358216664 bayes_pls_golite062009
substrate-specific channel activity 1.03912277255945 bayes_pls_golite062009
voltage-gated cation channel activity 0.978447945241838 bayes_pls_golite062009
transmembrane transporter activity 0.967232199555998 bayes_pls_golite062009
calcium ion binding 0.96333115642547 bayes_pls_golite062009
myosin heavy chain binding 0.962512315630951 bayes_pls_golite062009
voltage-gated ion channel activity 0.903772926548548 bayes_pls_golite062009
potassium channel activity 0.899316589086574 bayes_pls_golite062009
enzyme regulator activity 0.898362179169385 bayes_pls_golite062009
voltage-gated channel activity 0.890153400390069 bayes_pls_golite062009
gated channel activity 0.857277240351281 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.813441677689589 bayes_pls_golite062009
kinase activity 0.810725445632179 bayes_pls_golite062009
voltage-gated potassium channel activity 0.7995285225406 bayes_pls_golite062009
actin monomer binding 0.762790745478616 bayes_pls_golite062009
substrate-specific transporter activity 0.713088884599039 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.685857574037679 bayes_pls_golite062009
peptide binding 0.390501353810487 bayes_pls_golite062009
transferase activity 0.349179656858545 bayes_pls_golite062009
collagen binding 0.338418647767841 bayes_pls_golite062009
active transmembrane transporter activity 0.255162242356474 bayes_pls_golite062009
enzyme activator activity 0.224800334961602 bayes_pls_golite062009
troponin T binding 0.213896868973214 bayes_pls_golite062009
0.184502455796377 bayes_pls_golite062009
S100 beta binding 0.180796030292274 bayes_pls_golite062009
channel regulator activity 0.165732133218208 bayes_pls_golite062009
structural constituent of cytoskeleton 0.114682464671044 bayes_pls_golite062009
myosin II binding 0.0272025872757711 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.014511553141427 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [420-643] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTERNVFQCF VFGPKKSGKS ALLDSFLGRK FSNSYKATMG ERYAANVIDQ PGGSKKTLIL  60
   61 REIPEDRVKK FLTNKESLAA CDVAVVVYDS SDVYSWRKAR EILMEVARRG EERGYGTPCL 120
  121 LVAAKDDLDP YPMSVQESDR VCMELGIDIP VSLSMKLGEP NSLFSRIVST AENPHMSIPE 180
  181 TESGRRSRNI RQLVNSSLLF VSVGTAVGFA GLAAYRAYSA RKNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.69897
Match: 1ukvY
Description: Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 5.46515414027328 bayes_pls_golite062009
microfilament motor activity 4.83676058210847 bayes_pls_golite062009
GTPase activity 4.52394549632777 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 4.26230696590213 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
actin-dependent ATPase activity 3.43932260572328 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 3.35170865169069 bayes_pls_golite062009
actin binding 3.33639699088484 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
G-protein coupled receptor activity 2.3505608190884 bayes_pls_golite062009
actin filament binding 2.24723363507804 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
tubulin binding 1.92557767696163 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
microtubule binding 1.84561785126784 bayes_pls_golite062009
plus-end-directed microtubule motor activity 1.8063519626342 bayes_pls_golite062009
structural constituent of muscle 1.75982319871463 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
hydrolase activity 1.65763522573119 bayes_pls_golite062009
ADP binding 1.65139729685924 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
transmembrane receptor activity 1.26314334516725 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
receptor activity 1.20313362488821 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
kinase activity 1.11120928120082 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.97313818590443 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.97313818590443 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
GBD domain binding 0.914270985726459 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.908046791062776 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.69784475011795 bayes_pls_golite062009
potassium channel activity 0.694411056320469 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
steroid hormone receptor binding 0.647625526012423 bayes_pls_golite062009
calcium channel activity 0.636216614902039 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
nucleotide kinase activity 0.56979593127581 bayes_pls_golite062009
beta-catenin binding 0.567325521781475 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 0.563503770238611 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
DNA strand annealing activity 0.495691434532349 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.421921195209539 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
hormone receptor binding 0.351501100511918 bayes_pls_golite062009
protein kinase activity 0.351308564667977 bayes_pls_golite062009
peptide binding 0.304703625340488 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
myosin binding 0.274885859454447 bayes_pls_golite062009
voltage-gated calcium channel activity 0.25979628626254 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
nuclear hormone receptor binding 0.246160342138071 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
signal recognition particle binding 0.20866768220789 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
transferase activity 0.175269600441384 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009
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