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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Sit4. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ACC1
  • endoplasmic reticulum membrane
  • mitochondrion
  • cytosol
  • nuclear envelope organization
  • protein import into nucleus
  • fatty acid biosynthetic process
  • acetyl-CoA carboxylase activity
  • biotin carboxylase activity
  • ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • BGL2
  • fungal-type cell wall
  • cellular cell wall organization
  • glucan 1,3-beta-glucosidase activity
  • CCT6
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • FAA1
  • lipid particle
  • mitochondrion
  • mitochondrial outer membrane
  • lipid transport
  • lipid metabolic process
  • N-terminal protein myristoylation
  • long-chain fatty acid-CoA ligase activity
  • FAA4
  • lipid particle
  • cytoplasm
  • lipid transport
  • lipid metabolic process
  • N-terminal protein myristoylation
  • long-chain fatty acid-CoA ligase activity
  • GLT1
  • mitochondrion
  • glutamate synthase complex
  • glutamate biosynthetic process
  • glutamate synthase (NADH) activity
  • GSF2
  • cytoplasm
  • integral to endoplasmic reticulum membrane
  • mitochondrial outer membrane
  • secretory pathway
  • protein folding
  • molecular_function
  • MAE1
  • mitochondrion
  • cellular amino acid metabolic process
  • pyruvate metabolic process
  • malic enzyme activity
  • NDE1
  • mitochondrion
  • NADH oxidation
  • glucose catabolic process to ethanol
  • chronological cell aging
  • NADH dehydrogenase activity
  • NPA3
  • cytoplasm
  • biological_process
  • ATPase activity
  • RMT2
  • nucleus
  • cytoplasm
  • ribosome biogenesis
  • peptidyl-arginine methylation
  • protein-arginine N-methyltransferase activity
  • RNR2
  • nucleus
  • cytoplasm
  • ribonucleoside-diphosphate reductase complex
  • DNA replication
  • ribonucleoside-diphosphate reductase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SAP155
  • cytoplasm
  • G1/S transition of mitotic cell cycle
  • protein serine/threonine phosphatase activity
  • SAP185
  • cytoplasm
  • mitochondrion
  • G1/S transition of mitotic cell cycle
  • protein serine/threonine phosphatase activity
  • SAP190
  • cytoplasm
  • G1/S transition of mitotic cell cycle
  • protein serine/threonine phosphatase activity
  • SIT4
  • nucleus
  • cytoplasm
  • DNA repair
  • G1/S transition of mitotic cell cycle
  • cellular cell wall organization
  • telomere maintenance
  • intracellular protein kinase cascade
  • protein amino acid phosphorylation
  • replicative cell aging
  • actin cytoskeleton organization
  • protein serine/threonine phosphatase activity
  • TAP42
  • cellular_component
  • signal transduction
  • protein binding
  • YMR196W
  • cytoplasm
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    glutamate synthase complex 3.1786E-3 20 1 1 6292
    lipid particle 5.3639E-3 20 35 2 6292
    cytoplasm 6.983E-3 20 3552 17 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    G1/S transition of mitotic cell cycle 1.5571E-5 20 50 4 6292
    peptidyl-amino acid modification 7.6537E-5 20 27 3 6292
    protein myristoylation 9.5453E-5 20 5 2 6292
    N-terminal protein lipidation 9.5453E-5 20 5 2 6292
    N-terminal protein myristoylation 9.5453E-5 20 5 2 6292
    protein amino acid myristoylation 9.5453E-5 20 5 2 6292
    interphase of mitotic cell cycle 2.128E-4 20 97 4 6292
    interphase 2.128E-4 20 97 4 6292
    N-terminal protein amino acid modification 9.8331E-4 20 15 2 6292
    peptide or protein amino-terminal blocking 9.8331E-4 20 15 2 6292
    peptidyl-arginine methylation 3.1786E-3 20 1 1 6292
    lipid transport 5.9811E-3 20 37 2 6292
    peptidyl-arginine modification 6.3477E-3 20 2 1 6292
    lipid localization 6.6294E-3 20 39 2 6292
    mitotic cell cycle 7.641E-3 20 255 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein serine/threonine phosphatase activity 1.0615E-6 20 26 4 6292
    phosphoprotein phosphatase activity 8.4639E-6 20 43 4 6292
    phosphatase activity 1.3953E-4 20 87 4 6292
    long-chain fatty acid-CoA ligase activity 1.4291E-4 20 6 2 6292
    fatty acid ligase activity 1.4291E-4 20 6 2 6292
    catalytic activity 2.2436E-4 20 2150 15 6292
    phosphoric ester hydrolase activity 2.5834E-4 20 102 4 6292
    ligase activity, forming carbon-sulfur bonds 4.2546E-4 20 10 2 6292
    malic enzyme activity 3.1786E-3 20 1 1 6292
    biotin carboxylase activity 3.1786E-3 20 1 1 6292
    glutamate synthase (NADH) activity 3.1786E-3 20 1 1 6292
    glutamate synthase activity, NADH or NADPH as acceptor 3.1786E-3 20 1 1 6292
    glutamate synthase activity 3.1786E-3 20 1 1 6292
    acetyl-CoA carboxylase activity 6.3477E-3 20 2 1 6292
    CoA carboxylase activity 6.3477E-3 20 2 1 6292
    arginine N-methyltransferase activity 9.5071E-3 20 3 1 6292
    protein-arginine N-methyltransferase activity 9.5071E-3 20 3 1 6292
    NADH dehydrogenase activity 9.5071E-3 20 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle